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The relationship between obstructive sleep apnea and recurrence of atrial fibrillation after pulmonary vein isolation using a contact force–sensing catheter

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Abstract

Purpose

Our aim was to elucidate the relationship between obstructive sleep apnea (OSA) and atrial fibrillation (AF) recurrence after repeated pulmonary vein isolation (PVI).

Methods

We conducted a non-randomized observational study, with the data prospectively collected. One hundred patients (paroxysmal AF, n = 89) underwent PVI using a contact force–sensing catheter. All patients underwent an electrophysiological study and additional ablation for left atrium-pulmonary vein (PV) reconnection and non-PV foci, 6 months after the first treatment session, regardless of AF recurrence. Those with an apnea-hypopnea index ≥ 15 were diagnosed with OSA. Continuous positive air pressure (CPAP) therapy was initiated after the second treatment session, based on results of a sleep study. For analysis, patients were classified into the non-OSA (n = 66), treated OSA (OSA patients undergoing CPAP; n = 11), and untreated OSA (n = 23) groups, and between-group differences evaluated.

Results

After the first session, AF recurrence was observed in 18.2% (12/66) and 14.7% (5/34) of patients without and with OSA, respectively (P = 0.678). After the second procedure, the rate of AF recurrence was 12.1% (8/66) in the non-OSA group, 9.1% (1/11) in the treated OSA group, and 8.7% (2/23) in the untreated OSA group (log-rank P = 0.944).

Conclusions

The rate of AF recurrence might not be greater in patients with untreated OSA than in those without OSA and those with treated OSA after repeated PVI, using a contact force–sensing catheter, for patients with paroxysmal or short-term persistent AF.

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Authors and Affiliations

  1. Department of Cardiology, Tokyo Metropolitan Hiroo Hospital, 2-34-10, Ebisu, Shibuya-ku, Tokyo, 150-0013, Japan

    Rintaro Hojo, Seiji Fukamizu, Satoshi Miyazawa & Iwanari Kawamura

  2. Tokyo Metropolitan Health and Medical Treatment Corporation Ohkubo Hospital, Tokyo, Japan

    Harumizu Sakurada

  3. Tokyo Medical and Dental University, Tokyo, Japan

    Masayasu Hiraoka

Authors
  1. Rintaro Hojo
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  2. Seiji Fukamizu
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  3. Satoshi Miyazawa
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  4. Iwanari Kawamura
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  5. Harumizu Sakurada
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  6. Masayasu Hiraoka
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Contributions

Rintaro Hojo designed the study and wrote the initial draft of the manuscript. Seiji Fukamizu and Masayasu Hiraoka contributed to analysis and interpretation of data. All other authors have contributed to data collection and interpretation and critically reviewed the manuscript.

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Correspondence to Rintaro Hojo.

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The authors declare that they have no conflict of interest.

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Hojo, R., Fukamizu, S., Miyazawa, S. et al. The relationship between obstructive sleep apnea and recurrence of atrial fibrillation after pulmonary vein isolation using a contact force–sensing catheter. J Interv Card Electrophysiol 54, 209–215 (2019). https://doi.org/10.1007/s10840-018-0489-x

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  • DOI: https://doi.org/10.1007/s10840-018-0489-x

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