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Is there a relationship between hypoparathyroidism and retinal microcirculation?

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Abstract

Purpose

To investigate the retinal microvasculature in patients with surgically induced hypoparathyroidism who have no clinical evidence of retinopathy and to compare these data with those of healthy control subjects.

Methods

Forty patients with a confirmed diagnosis of permanent hypoparathyroidism and no clinical evidence of retinopathy and 37 age- and sex-matched healthy control subjects were included in the study. After complete ophthalmological examination, all patients underwent optical coherence tomography angiography measurement (Optovue Inc., Fremont, California, USA) to assess the foveal avascular zone (FAZ) area; FAZ perimeter; acircularity index of FAZ; foveal density-300; radial peripapillary capillary plexus (RPCP) vessel density; superficial, middle and deep capillary plexus vessel densities (SCP, MCP and DCP). The data from the right eyes of all participants were used for statistical analysis.

Results

The SCP and MCP vessel densities were significantly lower, and the RPCP whole image and peripapillary vessel densities were significantly higher than those in healthy control subjects (p < 0.05 for all). The DCP vessel densities of patients with surgically induced hypoparathyroidism were not significantly different from those of healthy control subjects (p > 0.05 for all). No significant difference was found in the FAZ area, FAZ perimeter, acircularity index of FAZ, foveal density-300 measurements between patients and controls (p > 0.05 for all).

Conclusions

Reduced retinal vessel density in patients with surgically induced hypoparathyroidism supports the hypothesis that parathyroid hormone is associated with regulation of vascular homeostasis, including macular microcirculation. Increased perfusion in the peripapillary area may suggest an early subclinic effect of hypoparathyroidism.

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Acknowledgements

The authors have no financial or proprietary interest in any of the materials mentioned in this article.

Funding

There were no external sources of funding obtained for this study.

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Authors and Affiliations

  1. Ulucanlar Eye Training and Research Hospital, 06240, Ankara, Turkey

    Hilal Kılınç Hekimsoy, Mehmet Ali Şekeroğlu & Ali Mert Koçer

  2. Ankara Training and Research Hospital, Ankara, Turkey

    Çağatay Emir Önder & Şerife Mehlika Kuşkonmaz

Authors
  1. Hilal Kılınç Hekimsoy
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  2. Mehmet Ali Şekeroğlu
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  3. Ali Mert Koçer
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  4. Çağatay Emir Önder
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  5. Şerife Mehlika Kuşkonmaz
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Correspondence to Hilal Kılınç Hekimsoy.

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Kılınç Hekimsoy, H., Şekeroğlu, M.A., Koçer, A.M. et al. Is there a relationship between hypoparathyroidism and retinal microcirculation?. Int Ophthalmol 40, 2103–2110 (2020). https://doi.org/10.1007/s10792-020-01387-4

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  • DOI: https://doi.org/10.1007/s10792-020-01387-4

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