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Cyclin D3/CDK11p58 Complex Involved in Schwann Cells Proliferation Repression Caused by Lipopolysaccharide

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Abstract

Schwann cells proliferation is the main characterize of kinds PNS inflammation diseases. It has been well documented that cyclin D3 /CDK11p58 complex inhibits cell function through multiple mechanisms, but the mechanism of cyclin D3/CDK11p58 complex exerts its repressive role in the Schwann cells proliferation remains to be identified. In the present investigation, we demonstrated that the expression of CDK11p58 were upregulated in the inflammation caused by LPS, a main part of bactria. Cyclin D3 and the 58-kDa isoform of cyclin-dependent kinase 11 (CDK11p58) interacted with each other mainly in nuclear region, repressed Schwann cells proliferation and induced cell apoptosis. Overexpression of CDK11p58 expression might enhance this process, while silence of cyclin D3 reverting it. This work demonstrates for the first time the role of cyclin D3/CDK11p58 complex in repressing the Schwann cells proliferation and inducing its apoptosis.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (No.30770488 and No.30870320); Natural Science Foundation of Jiangsu province (No.BK2006547); Health Project of Jiangsu Province (H200632); “Liu-Da-Ren-Cai-Gao-Feng” Financial Assistance of Jiangsu Province Grant (No.2); The Society and Technology Grew Project of Nantong City. (S2008020).

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Authors and Affiliations

  1. Laboratory Center, Affiliated Hospital of Nantong University, and Department of Parasitology and Microbiology, Medical College, Nantong University, 19 Qixiu Road, Nantong, 226001, People’s Republic of China

    Yinong Duan, **ngxin He, **ling Chen & Huimin Wang

  2. Department of Immunology, Medical College, Nantong University, Nantong, 226001, People’s Republic of China

    Huiguang Yang, Yuhong Ji, Tao Tao, Ling Hu, Fupeng Zhang, **aohong Li & Aiguo Shen

  3. The Second Affiliated Hospital of Nan**g, Medical University, 121# Jiang jia yuan Road, Nan**g, 210011, People’s Republic of China

    **ang Lu

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  1. Yinong Duan
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Correspondence to Aiguo Shen or **ang Lu.

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Yinong Duan and **ngxin He contributed equally to this work.

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Duan, Y., He, X., Yang, H. et al. Cyclin D3/CDK11p58 Complex Involved in Schwann Cells Proliferation Repression Caused by Lipopolysaccharide. Inflammation 33, 189–199 (2010). https://doi.org/10.1007/s10753-009-9173-8

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