Abstract
This opinion article offers a comprehensive analysis of recent developments in the exploration of endoplasmic reticulum (ER) stress signaling pathways and future opportunities for chemical mitigation strategies in plants. Encouraging results have been observed in the mitigation of ER stress in plants through the use of various chemical compounds commonly referred to as chemical chaperones; however, their mechanisms still require further exploration. The interconnectedness of stress responses is evident in the cross-talk between ER stress signaling and other stress signaling pathways. Additionally, the investigation of the role of ER stress signaling in plant defense and immunity has highlighted its significance in enhancing plant resistance. Looking ahead, future studies focusing on chemical mitigation of ER stress are positioned to provide valuable insights that can significantly expand our existing knowledge base. These advancements hold immense potential for enriching our understanding of ER stress signaling and facilitating the development of effective stress mitigation strategies in plants.
This is a preview of subscription content, log in via an institution to check access.
References
Ayaz A, Jalal A, Qian Z et al (2024a) Investigating the effects of tauroursodeoxycholic acid (TUDCA) in mitigating endoplasmic reticulum stress and cellular responses in pak choi. Physiol Plant 176:e14246. https://doi.org/10.1111/ppl.14246
Ayaz A, Jalal A, Zhang X et al (2024b) In-Depth characterization of bZIP genes in the context of endoplasmic reticulum (ER) stress in Brassica campestris ssp. chinensis. Plants 13:1160. https://doi.org/10.3390/plants13081160
Bao Y, Howell SH (2017) The unfolded protein response supports Plant Development and Defense as well as responses to Abiotic Stress. Front Plant Sci 8
Benham AM (2019) Endoplasmic reticulum redox pathways: in sickness and in health. FEBS J 286:311–321. https://doi.org/10.1111/febs.14618
Choi J-A, Song C-H (2020) Insights into the role of endoplasmic reticulum stress in Infectious diseases. Front Immunol 10
Czékus Z, Csíkos O, Ördög A et al (2020) Effects of Jasmonic Acid in ER stress and unfolded protein response in Tomato plants. Biomolecules 10:1031. https://doi.org/10.3390/biom10071031
de Souza A, Wang J-Z, Dehesh K (2017) Retrograde signals: Integrators of Interorganellar Communication and Orchestrators of Plant Development. Annu Rev Plant Biol 68:85–108. https://doi.org/10.1146/annurev-arplant-042916-041007
Deng Y, Humbert S, Liu J-X et al (2011) Heat induces the splicing by IRE1 of a mRNA encoding a transcription factor involved in the unfolded protein response in Arabidopsis. Proceedings of the National Academy of Sciences 108:7247–7252. https://doi.org/10.1073/pnas.1102117108
Dupzyk A, Tsai B (2016) How Polyomaviruses exploit the ERAD Machinery to cause infection. Viruses 8:242. https://doi.org/10.3390/v8090242
Hemagirri M, Chen Y, Gopinath SCB et al (2023) Crosstalk between protein misfolding and endoplasmic reticulum stress during ageing and their role in age-related disorders. https://doi.org/10.1016/j.biochi.2023.10.019. Biochimie
Howell SH (2021) Evolution of the unfolded protein response in plants. Plant Cell Environ 44:2625–2635. https://doi.org/10.1111/pce.14063
Kanehara K, Cho Y, Yu C-Y (2022) A lipid viewpoint on the plant endoplasmic reticulum stress response. J Exp Bot 73:2835–2847
Kim J-S, Yamaguchi-Shinozaki K, Shinozaki K (2018) ER-Anchored transcription factors bZIP17 and bZIP28 regulate Root Elongation. Plant Physiol 176:2221–2230. https://doi.org/10.1104/pp.17.01414
Kumari D, Brodsky JL (2021) The targeting of native proteins to the endoplasmic Reticulum-Associated degradation (ERAD) pathway: an expanding repertoire of regulated substrates. Biomolecules 11:1185. https://doi.org/10.3390/biom11081185
Liu L, Li J (2019) Communications between the endoplasmic reticulum and other organelles during abiotic stress response in plants. Front Plant Sci 10
Lu S-J, Yang Z-T, Sun L et al (2012) Conservation of IRE1-Regulated bZIP74 mRNA unconventional splicing in Rice (Oryza sativa L.) involved in ER stress responses. Mol Plant 5:504–514. https://doi.org/10.1093/mp/ssr115
Manghwar H, Li J (2022) Endoplasmic reticulum stress and unfolded protein response signaling in plants. Int J Mol Sci 23:828. https://doi.org/10.3390/ijms23020828
Nawkar GM, Lee ES, Shelake RM et al (2018) Activation of the transducers of unfolded protein response in plants. Front Plant Sci 9
Paes de Melo B, Carpinetti P, de Fraga A OT, et al (2022) Abiotic stresses in plants and their markers: a practice view of plant stress responses and programmed cell death mechanisms. Plants 11:1100. https://doi.org/10.3390/plants11091100
Pastor-Cantizano N, Ko DK, Angelos E et al (2020) Functional diversification of ER stress responses in Arabidopsis. Trends Biochem Sci 45:123–136. https://doi.org/10.1016/j.tibs.2019.10.008
Pu Y, Ruberti C, Angelos ER, Brandizzi F (2019) AtIRE1C, an unconventional isoform of the UPR master regulator AtIRE1, is functionally associated with AtIRE1B in Arabidopsis gametogenesis. Plant Direct 3:e00187. https://doi.org/10.1002/pld3.187
Ren J, Bi Y, Sowers JR et al (2021) Endoplasmic reticulum stress and unfolded protein response in cardiovascular diseases. Nat Rev Cardiol 18:499–521. https://doi.org/10.1038/s41569-021-00511-w
Schwarz DS, Blower MD (2016) The endoplasmic reticulum: structure, function and response to cellular signaling. Cell Mol Life Sci 73:79–94. https://doi.org/10.1007/s00018-015-2052-6
Srivastava R, Deng Y, Shah S et al (2013) BINDING PROTEIN is a Master Regulator of the endoplasmic reticulum stress Sensor/Transducer bZIP28 in Arabidopsis. Plant Cell 25:1416–1429. https://doi.org/10.1105/tpc.113.110684
Srivastava R, Li Z, Russo G et al (2018) Response to persistent ER stress in plants: a multiphasic process that transitions cells from Prosurvival activities to Cell Death[OPEN]. Plant Cell 30:1220–1242. https://doi.org/10.1105/tpc.18.00153
Stefano G, Brandizzi F (2018) Advances in Plant ER Architecture and Dynamics1[OPEN]. Plant Physiol 176:178–186. https://doi.org/10.1104/pp.17.01261
Sun L, Yang Z-T, Song Z-T et al (2013) The plant-specific transcription factor gene NAC103 is induced by bZIP60 through a new cis-regulatory element to modulate the unfolded protein response in Arabidopsis. Plant J 76:274–286. https://doi.org/10.1111/tpj.12287
Wakasa Y, Hayashi S, Ozawa K, Takaiwa F (2012) Multiple roles of the ER stress sensor IRE1 demonstrated by gene targeting in rice. Sci Rep 2:944. https://doi.org/10.1038/srep00944
Westrate LM, Lee JE, Prinz WA, Voeltz GK (2015) Form follows function: the importance of endoplasmic reticulum shape. Annu Rev Biochem 84:791–811. https://doi.org/10.1146/annurev-biochem-072711-163501
Yang Z-T, Lu S-J, Wang M-J et al (2014a) A plasma membrane-tethered transcription factor, NAC062/ANAC062/NTL6, mediates the unfolded protein response in Arabidopsis. Plant J 79:1033–1043. https://doi.org/10.1111/tpj.12604
Yang Z-T, Wang M-J, Sun L et al (2014b) The membrane-Associated transcription factor NAC089 controls ER-Stress-Induced programmed cell death in plants. PLoS Genet 10:e1004243. https://doi.org/10.1371/journal.pgen.1004243
Yu X, Wang T, Zhu M et al (2019) Transcriptome and physiological analyses for revealing genes involved in wheat response to endoplasmic reticulum stress. BMC Plant Biol 19:193. https://doi.org/10.1186/s12870-019-1798-7
Zang Y, Gong Y, Wang Q et al (2020) Arabidopsis OTU1, a linkage-specific deubiquitinase, is required for endoplasmic reticulum-associated protein degradation. Plant J 101:141–155. https://doi.org/10.1111/tpj.14524
Acknowledgements
The first author of the paper is very grateful to China Scholarship Council (CSC) for providing funds for perusing her PhD studies from the College of Horticulture, Nan**g Agricultural University Nan**g 210095, Jiangsu, China.
Funding
This work was supported by China’s national science and technology basic resources survey project (2023FY101202) and China’s national vegetable industry technology system (CARS-23-A-16).
Author information
Authors and Affiliations
Contributions
Conceptualization, literature survey, and writing- Original draft (A.A); Writing- Review and Editing (C.H and Y.L). All authors have reviewed and agreed for the final version of the manuscript.
Corresponding authors
Ethics declarations
Conflict of interest
The authors declare no conflict on interests.
Additional information
Publisher’s Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Ayaz, A., Hu, C. & Li, Y. Current advances and future prospects of ER stress signaling and its chemical mitigation in plants. Plant Growth Regul (2024). https://doi.org/10.1007/s10725-024-01172-8
Received:
Accepted:
Published:
DOI: https://doi.org/10.1007/s10725-024-01172-8