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Epidemiology and Socioeconomic Impact of Pancreatic Cancer: An Analysis of the Global Burden of Disease Study 1990–2019

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Abstract

Introduction

The aim of this study is to estimate the global burden of pancreatic cancer from 1990 to 2019.

Methods

We reconstructed the Global Burden of Diseases (GBD) study results for pancreatic cancer across 204 countries and territories. Our study generated estimates for key disease burden indicators, including incidence, prevalence, mortality, and disability-adjusted life years (DALYs), and cost. Linear regression analysis of the natural logarithm of age-standardized outcomes was used to calculate annual percent change.

Results

In 2019, there were a total of 530,296 incident and 442,101 prevalent cases of pancreatic cancer, resulting in 531,107 deaths and 11.5 million DALYs lost. The age-standardized incidence and prevalence of pancreatic cancer has increased from 5.22 (95% CI 4.97–5.40) to 6.57 (CI 6.00–7.09) per 100,000 people per year, and 4.1 (95% CI 3.95–4.26) to 5.4 (CI 4.96–5.87), respectively. This equated to 10 million (95% CI 9.5 to 10.4 million) incident cases of pancreatic cancer. The number of DALYs lost as a result of pancreatic cancer was 225 million years (95% CI 216–234 million years). Mortality from pancreatic cancer increased over the study period from 3.7 (95% CI 3.54–3.83) to 6.9 (95% CI 6.36–7.32). Incidence, prevalence, DALYs, and mortality were higher in countries with a higher socio-demographic index.

Conclusions

Pancreatic cancer is rising around the world and is associated with a high economic burden. Programs aimed at reducing modifiable risk factors are needed.

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Author information

Authors and Affiliations

  1. Division of Gastroenterology, Hepatology, and Nutrition, University of Utah Health, Salt Lake City, UT, USA

    Daryl Ramai & John D. Morris

  2. Department of Medicine, Baylor Scott & White Health, Round Rock, TX, USA

    Eric R. Smith

  3. Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA

    Yichen Wang

  4. Division of Gastroenterology and Hepatology, Mayo Clinic Florida, Jacksonville, FL, USA

    Yuting Huang

  5. Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, IN, USA

    Itegbemie Obaitan

  6. Division of Gastroenterology, Creighton University School of Medicine, Creighton University, Omaha, NE, USA

    Saurabh Chandan

  7. Division of Gastroenterology and Hepatology, NYU Langone, New York, NY, USA

    Banreet Dhindsa

  8. Endoscopy, UCLH, London, UK

    Apostolis Papaefthymiou

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  1. Daryl Ramai
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  2. Eric R. Smith
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  3. Yichen Wang
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  8. Apostolis Papaefthymiou
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  9. John D. Morris
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Contributions

DR conceived and designed the study. DR, ESR, YW, and YH collected the data. DR and ERS conducted data analysis. DR drafted the manuscript. BD, IO, SC, AP, and JM revised the manuscript for intellectual content. All authors approved the final version of the manuscript.

Corresponding author

Correspondence to Daryl Ramai.

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Ramai, D., Smith, E.R., Wang, Y. et al. Epidemiology and Socioeconomic Impact of Pancreatic Cancer: An Analysis of the Global Burden of Disease Study 1990–2019. Dig Dis Sci 69, 1135–1142 (2024). https://doi.org/10.1007/s10620-024-08292-1

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