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Two New Chromeno[3,2-c]Pyridine Derivatives from the Whole Plants of Thalictrum finetii and Their Antirotavirus Activity

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Chemistry of Natural Compounds Aims and scope

Two new chromeno[3,2-c]pyridin derivatives, 8-acetyl-3-(hydroxymethyl)-7-methoxy-10H-chromeno[3,2-c]pyridin-10-one (1) and 8-acetyl-3-isopropyl-7-methoxy-10H-chromeno[3,2-c]pyridin-10-one (2), were isolated from the whole plants of Thalictrum finetii. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1 and 2 were tested for their antirotavirus activity. The results revealed that compounds 1 and 2 exhibited high antirotavirus activity with therapeutic index (TI) values of 19.7 and 17.1. These values are close to that of positive control (21.6).

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Acknowledgment

This project was supported by the National Natural Science Foundation of China (No. 21762050), the Yunnan Applied Basic Research Projects for Excellent Young Scholars (Grant to M.Z.), and the Foundation of Yunnan Innovative Research Team (2019HC020).

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Authors and Affiliations

  1. Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, 650031, Kunming, P. R. China

    Qiu-Fen Hu, Ling-Fang Zhang, Ming-**n Liu, Tao Zhou, Man-Fei Li, Hua-Shun Wang & Min Zhou

  2. Key Laboratory of Tobacco Chemistry of Yunnan Province, China Tobacco Yunnan Industrial Co., Ltd., 650231, Kunming, P. R. China

    Qiu-Fen Hu, Bing-Biao Cai, Yong Li, Tao Zhou, Yong Xu, Wei-Song Kong, Guang-Yu Yang & Ju-**ng Jiang

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  1. Qiu-Fen Hu
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  2. Ling-Fang Zhang
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  4. Bing-Biao Cai
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  5. Yong Li
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  11. Min Zhou
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  12. Guang-Yu Yang
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  13. Ju-**ng Jiang
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Correspondence to Qiu-Fen Hu or Ju-**ng Jiang.

Additional information

Published in Khimiya Prirodnykh Soedinenii, No. 3, May–June, 2022, pp. 435–438.

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Hu, QF., Zhang, LF., Liu, MX. et al. Two New Chromeno[3,2-c]Pyridine Derivatives from the Whole Plants of Thalictrum finetii and Their Antirotavirus Activity. Chem Nat Compd 58, 511–515 (2022). https://doi.org/10.1007/s10600-022-03720-y

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  • DOI: https://doi.org/10.1007/s10600-022-03720-y

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