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Two New Benzazepine Alkaloids from Thalictrum wangii and their Anti-Rotavirus Activity

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Chemistry of Natural Compounds Aims and scope

Two new benzazepine alkaloids (1 and 2) were isolated from the whole plants of Thalictrum wangii. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1 and 2 were tested for their anti-rotavirus activity. The results revealed that compounds 1 and 2 exhibited potent anti-rotavirus activity with TI values of 17.9 and 17.6, respectively.

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References

  1. D. C. Hao, Ranunculales Medicinal Plants, Biodiversity, Chapter 7 – Biodiversity, Chemodiversity, and Pharmacotherapy of Thalictrum Medicinal Plants, Elsevier Science Publisher B.V., Amsterdam, 2019, p. 261.

  2. C. Y. Wang, Flora of China, Vol. 27, 2nd Section, Chinese Science Press, Bei**g, 2001, p. 282.

  3. C. H. Han, Q. Liu, J. H. Liu, and Y. Q. Zhang, Agric. Sci. Technol., 14, 54 (2013).

    Google Scholar 

  4. Y. J. Zou, D. Z. Huang, and X. Du, J. Ethnomed. Ethnopharm., 1, 20 (2003).

    Google Scholar 

  5. T. A. Al-Howiriny, M. A. Zemaitis, C. Y. Gao, C. E. Hadden, G. E. Martin, F. T. Lin, and P. L Schiff, J. Nat. Prod., 64, 819 (2001).

  6. Q. **, D. Yang, Z. Dai, A. Khan, B. Wang, X. Wei, Y. Sun, Y. L. Zhao, Y. F. Wang, Y. P. Liu, X. D. Zhao, and X. D. Luo, Fitoterapia, 128, 204 (2018).

    Article  CAS  Google Scholar 

  7. P. L. Schiff, in: Alkaloids: Chemical and Biological Perspectives, Vol. 11, Chapter One, The Thalictrum Alkaloids: Chemistry and Pharmacology, Elsevier B. V., 1996, pp. 1–236.

  8. J. L. Stanton, J. W. Watthey, M. N, Desai, B. M. Finn, J. E. Babiarz, and H. C. Tomaselli, J. Med. Chem., 28, 1603 (1985).

  9. M. B. Niel, S. B. Freedman, V. G. Matassa, S. Patel, R. R. Pengilley, and A. J. Smith, Bioorg. Med. Chem. Lett., 5, 1421 (1995).

    Article  Google Scholar 

  10. R. B. Han, Y. P. Shao, H. F. Wu, D. Zhang, and F. Y. Piao, Med. Chem. Res., 23, 2810 (2014).

    Article  CAS  Google Scholar 

  11. N. Lv, D. Luo, L. J. Zhu, Y. Xu, J. Wang, W. S. Kong, J. Li, Q. Gao, Q. L. Mi, M. Zhou, G. Y. Yang, Q. F. Hu, and H. T. Huang, Chem. Nat. Compd., 56, 697 (2020).

    Article  Google Scholar 

  12. J. S. Pudlo, M. R. Nassiri, E. R. Kern, L. L. Wotring, J. C. Drach, and L. B. Townsend, J. Med. Chem., 33, 1984 (1990).

    Article  CAS  Google Scholar 

  13. B. K. Ji, X. M. Gao, D. Cui, S. S. Wang, W. Z. Huang, Y. K. Li, S. X. Mei, Z. Yang, G. P. Li, M. Y. Jiang, Y. H. He, Z. Y. Jiang, G. Du, X. X. Pan, W. X. Liu, and Q. F. Hu, Nat. Prod. Res., 31, 1544 (2017).

    Article  CAS  Google Scholar 

  14. X. M. Gao, B. K. Ji, Y. K. Li, Y. Q. Ye, Z. Y. Jiang, H. Y. Yang, G. Du, M. Zhou, X. X. Pan, W. X. Liu, and Q. F. Hu, J. Braz. Chem. Soc., 27, 10 (2016).

    CAS  Google Scholar 

Download references

Acknowledgment

This project was supported by the National Natural Science Foundation of China (No. 21762050), the Applied Basic Research Foundation of Yunnan Province (No. 2017FB014), and the Foundation of Yunnan Innovative Research Team.

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Authors and Affiliations

  1. Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, 650031, Kunming, P. R. China

    Fang Wu, Lu Liu, Ya-Ning Zhu, Na Lv, Dian Luo, Li-Jun Zhu, Miao Dong, Min Zhou, Wei-Guang Wang & Qiu-Fen Hu

  2. Agricultural Information Center of Agriculture Department, Yunnan Province, 650032, Kunming, P. R. China

    Zhi-Gang Li

Authors
  1. Fang Wu
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  2. Lu Liu
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  3. Ya-Ning Zhu
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  4. Na Lv
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  5. Dian Luo
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  9. Wei-Guang Wang
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  10. Qiu-Fen Hu
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  11. Zhi-Gang Li
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Corresponding authors

Correspondence to Qiu-Fen Hu or Zhi-Gang Li.

Additional information

Published in Khimiya Prirodnykh Soedinenii, No. 2, March–April, 2021, pp. 289–291.

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Wu, F., Liu, L., Zhu, YN. et al. Two New Benzazepine Alkaloids from Thalictrum wangii and their Anti-Rotavirus Activity. Chem Nat Compd 57, 339–342 (2021). https://doi.org/10.1007/s10600-021-03346-6

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  • DOI: https://doi.org/10.1007/s10600-021-03346-6

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