A new prenylated flavanonol, (2R,3R)-8-isopentenyl-5-methoxy-7,2′,4′-trihydroxyflavanonol (1) was isolated from the roots of Sophora flavescens. The structure was elucidated on the basis of spectroscopic data. Compound 1 exhibited moderate inhibition towards HeLa, HepG2, and HL-60 tumor cell lines at 14.3, 19.2, 31.5 μg/mL, respectively.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Y. P. Zhu, Chinese Materia Medica: Chemistry, Pharmacology and Applications, Harwood Academic Publisher, Amsterdam, 1998, p. 149.
W. Lei, X. Wu, J. He, G. Li, L. Peng, L. Yan, L. Song, and Q. Zhao, Chem. Nat. Compd., 50, 876 (2014).
Y. Shen, Z. M. Feng, J. S. Jiang, Y. N. Yang, and P. C. Zhang, J. Nat. Prod., 76, 2337 (2013).
Y. Ding, R. H. Tian, J. Kinjo, T. Nohara, and I. Kitagawa, Chem. Pharm. Bull., 40, 2990 (1992).
D. N. Olennikov, L. M. Tankhaeva, and D. V. Sandanov, Chem. Nat. Compd., 45, 225 (2009).
M. Kuroyanagi, T. Arakawa, Y. Hirayama, and T. Hayashi, J. Nat. Prod., 62, 1595 (1999).
P. L. Zhang, G. Wang, J. S. Liu, F. Q. Xu, Z. Z. Zhao, W. X. Wang, J. T. Wang, G. K. Wang, and P. Y. Wu, Phytochem. Lett., 26, 50 (2018).
Acknowledgment
This work was supported by the National Natural Science Foundation of China (NSFC, No. 81860716) and Fundamental Research Funds for the Central Universities (Grant Nos. 31920200030, 31920190096, 31920190004, and 31920200047). Ya-Qing Zhang and Fei Zhao contributed equally to this work.
Author information
Authors and Affiliations
Corresponding author
Additional information
Published in Khimiya Prirodnykh Soedinenii, No. 1, January–February, 2021, pp. 21–22.
Rights and permissions
About this article
Cite this article
Zhang, YQ., Zhao, F., Ma, JX. et al. A New Prenylated Flavanonol from the Roots of Sophora flavescens. Chem Nat Compd 57, 20–22 (2021). https://doi.org/10.1007/s10600-021-03271-8
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10600-021-03271-8