A cucurbitane triterpenoid, 7β-butoxy-3β-hydroxy-25-methoxycucurbita-5,23(E)-dien-19-al (1), was isolated from the fruit pulp of Momordica charantia. Structure determination of the new compound was accomplished by spectroscopic analyses including 1D and 2D NMR (1H, 13C, COSY, HMQC, HMBC, and NOESY) and EI-MS and comparison with the data of known analogues.
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References
E. S. Chipps, R. Jayini, S. Ando, A. D. Protzman, M. Z. Muhi, M. A. Mottaleb, A. Malkawi, and M. R. Islam, Nat. Prod. Commun., 7, 1203 (2012).
S. S. Rathi, J. K. Grover, and V. Vats, Phytother. Res., 16, 236 (2002).
M. Kobori, H. Nakayama, K. Fukushima, M. Ohnishi-Kameyama, H. Ono, T. Fukushima, Y. Akimoto, S. Masumoto, C. Yukizaki, Y. Hoshi, T. Deguchi, and M. Yoshida, J. Agric. Food Chem., 56, 4004 (2008).
L. Harinantenaina, M. Tanaka, S. Takaoka, M. Oda, O. Mogami, M. Uchida, and Y. Asakawa, Chem. Pharm. Bull., 54, 1017 (2006).
Y. Liu, Z. Ali, and I. A. Khan, Planta Med., 74, 1291 (2008).
P. C. Hsiao, C. C. Liaw, S. Y. Hwang, H. L. Cheng, L. J. Zhang, C. C. Shen, F. L. Hsu, and Y. H. Kuo, J. Agric. Food Chem., 61, 2979 (2013).
P. H. Yen, D. T. Dung, N. X. Nhiem, T. Anh Hle, D. T. Hang, D. T. Yen, N. T. Cuc, N. K. Ban, C. Van Minh, and P. Van Kiem, Nat. Prod. Commun., 9, 383 (2014).
W. Kuanhuta, T. Aree, S. Pornpakakul, and P. Sawasdee, Nat. Prod. Commun., 9, 765 (2014).
C. C. Liaw, H. C. Huang, P. C. Hsiao, L. J. Zhang, Z. H. Lin, S. Y. Hwang, F. L. Hsu, and Y. H. Kuo, Planta Med., 81, 62 (2015).
Y. Miyahara, H. Okabe, and T. Yamauchi, Chem. Pharm. Bull., 29, 1561 (1981).
H. Okabe, Y. Miyahara, T. Yamauchi, K. Miyahara, and T. Kawasaki, Chem. Pharm. Bull., 28, 2753 (1980).
L. Ma, A. H. Yu, L. L. Sun, W. Gao, M. M. Zhang, Y. L. Su, H. Liu, and T. Ji, Molecules, 19, 2238 (2014).
J. Chen, R. Tian, M. Qiu, L. Lu, Y. Zheng, and Z. Zhang, Phytochemistry, 69, 1043 (2008).
M. Yasuda, M. Iwamoto, H. Okabe, and T. Yamauchi, Chem. Pharm. Bull., 32, 2044 (1984).
J. C. Chen, W. Q. Liu, L. Lu, M. H. Qiu, Y. T. Zheng, L. M. Yang, X. M. Zhang, L. Zhou, and Z. R. Li, Phytochemistry, 70, 133 (2009).
Y. B. Zhang, H. Liu, C. Y. Zhu, M. X. Zhang, Y. L. Li, B. Ling, and G. C. Wang, J. Asian Nat. Prod. Res., 16, 358 (2014).
J. Zhang, Y. Huang, T. Kikuchi, H. Tokuda, N. Suzuki, K. Inafuku, M. Miura, S. Motohashi, T. Suzuki, and T. Akihisa, Chem. Biodiv., 9, 428 (2012).
G. T. Zhao, J. Q. Liu, Y. Y. Deng, H. Z. Li, J. C. Chen, Z. R. Zhang, L. Zhou, and M. H. Qiu, Fitoterapia, 95, 75 (2014).
Y. C. Li, X. J. Xu, J. Yang, X. G. Wu, and Q. Y. Fu, Nat. Prod. Res., 30, 973 (2016).
C. I. Chang, C. R. Chen, Y. W. Liao, H. L. Cheng, Y. C. Chen, and C. H. Chou, J. Nat. Prod., 69, 1168 (2006).
C. I. Chang, C. R. Chen, Y. W. Liao, H. L. Cheng, Y. C. Chen, and C. H. Chou, J. Nat. Prod., 71, 1327 (2008).
C. I. Chang, C. R. Chen, Y. W. Liao, W. L. Shih, H. L. Cheng, C. Y. Tzeng, J. W. Li, and M. T. Kung, Chem. Pharm. Bull., 58, 225 (2010).
C. R. Chen, Y. W. Liao, W. L. Shih, C. Y. Tzeng, and C. I. Chang, Helv. Chim. Acta, 93, 1355 (2010).
C. R. Chen, Y. W. Liao, L. Wang, Y. H. Kuo, H. J. Liu, W. L. Shih, H. L. Cheng, and C. I. Chang, Chem. Pharm. Bull., 58, 1639 (2010).
Y. W. Liao, C. R. Chen, Y. H. Kuo, J. L. Hsu, W. L. Shih, H. L. Cheng, T. C. Huang, and C. I. Chang, Nat. Prod. Commun., 7, 1575 (2012).
Y. W. Liao, C. R. Chen, J. J. Chuu, H. C. Huang, J. L. Hsu, T. C. Huang, Y. H. Kuo, and C. I. Chang, J. Chin. Chem. Soc., 60, 526 (2013).
Acknowledgment
This research was supported by grants from the Ministry of Science and Technology, Taiwan (MOST 105-2320-B-020-002-MY3 and NSC 102-2313-B-020-010-MY3). We thank Ms. Shu-Yun Sun and Ms Lih-Mei Sheu for the MS measurements in the Instrumentation Center of the College of Science, National Taiwan University and National Chung Hsing University. We are also grateful to the National Center for High-performance Computing for computer time and facilities.
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Published in Khimiya Prirodnykh Soedinenii, No. 5, September–October, 2020, pp. 745–747.
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Chen, CR., Liao, YW., Hsu, JL. et al. A Cucurbitane Aldehyde from the Fruit Pulp of Momordica charantia. Chem Nat Compd 56, 870–873 (2020). https://doi.org/10.1007/s10600-020-03172-2
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DOI: https://doi.org/10.1007/s10600-020-03172-2