5′-Nitro- (2) and 5′-aminodubamine (3) were sequentially synthesized from the alkaloid dubamine. Condensation of 3 with 15 aldehydes gave imines, reduction of which produced secondary amines. Studies of the cytotoxicities for HeLa and HEp-2 cells of the compounds at a concentration of 100 μM revealed several trends. The activity decreased significantly or disappeared at lower concentrations although compound 5o at concentrations of 1–10 μM was active for HEp-2 cells at the level of cisplatin.
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Acknowledgment
The work was financially supported by the Ministry of Innovative Development, Cabinet of Ministers, Republic of Uzbekistan (Grant MRU-FA-21/2017).
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Translated from Khimiya Prirodnykh Soedinenii, No. 3, May–June, 2020, pp. 439–444.
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Niyazmetov, A.R., Terent’eva, E.O., Khamidova, U.B. et al. Synthesis of Derivatives of the 2-Arylquinoline Alkaloid Dubamine and their Cytotoxicity. Chem Nat Compd 56, 511–517 (2020). https://doi.org/10.1007/s10600-020-03074-3
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DOI: https://doi.org/10.1007/s10600-020-03074-3