Andrographolide is a labdane diterpenoid from Andrographis paniculata and has been used in the clinic for several decades to treat a variety of diseases in east Asia. In the present study, modification of 12-thioether andrographolide was carried out to seek compounds with better antitumor activity and drug-like properties. A series of novel 3,19-modified thioether andrographolide derivatives were synthesized and evaluated for their in vitro anticancer activities against human breast cancer cells. The results are promising and important in the further development of anticancer agents.
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Acknowledgment
This work was supported by the Introduction Program of Scientific Research of Sichuan University of Science & Engineering (2016RCL07, 2017RCL61), Innovation and Entrepreneurship Training Program for College Students of Sichuan Province (201810622007), the Scientific Research Fund of the Sichuan Provincial Education Department (15ZB0211, 18ZA0360), and the Opening Project of Key Laboratory of Green Chemistry of Sichuan Institutes of Higher Education (LYJ1505, LZJ18202). The authors Zhi Zheng and Ren-Ming Liang contributed equally to the work.
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Published in Khimiya Prirodnykh Soedinenii, No. 2, March–April, 2020, pp. 231–235.
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Cheng, CR., Zheng, Z., Liang, RM. et al. Preparation and Cytotoxic Activity of 3,19-Analogues of 12-Thioether Andrographolide. Chem Nat Compd 56, 264–269 (2020). https://doi.org/10.1007/s10600-020-03003-4
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DOI: https://doi.org/10.1007/s10600-020-03003-4