A new flavonoid glycoside, named desmiflavanoside (1), was isolated from the MeOH extract of Desmidorchis flava (N.E.Br.) Meve & Liede, and its structure was elucidated based on 1D and 2D NMR spectroscopic techniques as well as mass spectrometry. Preliminary studies demonstrated that although compound 1 is moderately cytotoxic at lower concentrations, its activity plateaus at higher concentrations. Notably, compound 1 demonstrated a significant dose-dependent response to lipid peroxidation and that its antilipid peroxidation was similar (89.6 ± 0.81%) to the known standard (BHT; 91.3 ± 0.49%; p < 0.051). On the other hand, the flavone glycoside 1 did not show inhibitory effects against urease and acetylcholinesterase enzymes.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
M. A. Raees, H. Hussain, A. Al-Rawahi, R. Csuk, S. A. Muhammad, H. Y. Khan, N. U. Rehman, G. Abbas, M. A. Al-Broumi, I. R. Green, A. Elyassi, T. Mahmood, and A. Al-Harrasi, Bioorg. Chem., 67, 95 (2016).
H. Hussain, M. A. Raees, N. U. Rehman, A. Al-Rawahi, R. Csuk, H. Y. Khan, G. Abbas, M. A. Al-Broumi, I. R. Green, A. Elyassi, T. Mahmood, and A. Al-Harrasi, Arch. Pharm. Res., 38, 2137 (2015).
M. A. Raees, H. Hussain, N. U. Rehman, H. Y. Khan, G. Abbas, A. Al-Rawahi, A. Elyassi, I. S. Al-Amri, I. R. Green, M. A. Al-Broumi, T. Mahmood, and A. Al-Harrasi, Phytochem. Lett., 12, 153 (2015).
M. A. Raees, H. Hussain, A. Al-Rawahi, R. Csuk, A. Al-Ghafri, N. U. Rehman, A. Elyassi, I. R. Green, T. Mahmood, and A. Al-Harrasi, Phytochem. Lett., 16, 230 (2016).
M. Kassema, S. A. Mosharrafa, N. A. M. Saleh, and S. M. Abdel-Wahab, Fitoterapia, 71, 649 (2000).
P. K. Agrawal, in: Carbon-13 NMR of Flavonoids, Elsevier, Amsterdam, 1989, p. 297.
V. Gulati, I. H. Harding, and E. A. Palombo, BMC Complem. Altern. Med., 12, 77 (2012).
Acknowledgment
The authors thank the Oman Research Council (TRC) for generous support of the project (ORG/HSS/14/004).
Author information
Authors and Affiliations
Corresponding authors
Additional information
Published in Khimiya Prirodnykh Soedinenii, No. 6, November–December, 2018, pp. 899–901.
Rights and permissions
About this article
Cite this article
Rehman, N.U., Hussain, H., Khan, H.Y. et al. Desmiflavanoside, a New Bioactive Flavonoid Glycoside Isolated from Desmidorchis flava. Chem Nat Compd 54, 1057–1060 (2018). https://doi.org/10.1007/s10600-018-2554-1
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10600-018-2554-1