Abstract
Neuroinflammation has been implicated in the etiology of Alzheimer’s disease (AD). Many studies have suggested that C(-889) T promoter polymorphism in one of the proinflammatory cytokine interleukin-1 (IL-1) encoding gene IL-1A may be associated with AD pathogenesis. To determine whether the polymorphism contributes to the risk for late-onset AD (LOAD) in Chinese, we carried out our investigation in 344 sporadic LOAD patients and 224 healthy controls. No statistical significant association was obtained between IL-1A C(-889) T polymorphism and LOAD and no statistical difference was found between cases and controls after stratification for apolipoprotein E allele 4 (APOE ε4) status. The results reveal that it is not likely that the IL-1A C(-889) T polymorphism is involved in AD pathogenesis in the Chinese population. Further studies of the associations between other IL-1A genetic polymorphisms and AD should be performed in a larger population and biologic functional analysis of IL-1A gene is required to verify the underlying roles of IL-IA in LOAD.
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Acknowledgments
This research was supported by Natural Science Found of China (30270491) and the Funds for Key Sci-tech Research Projects of Guangdong Province [YUE KEJIBAN (2004) 08, (2007) 05/06-7005206], [YUE CAIQI (2003)209] of China.
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Hu, Jl., Li, G., Zhou, Dx. et al. Genetic Analysis of Interleukin-1A C(-889)T Polymorphism with Alzheimer Disease. Cell Mol Neurobiol 29, 81–85 (2009). https://doi.org/10.1007/s10571-008-9299-5
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DOI: https://doi.org/10.1007/s10571-008-9299-5