Abstract
Photodynamic antibacterial composite membranes were engineered by integrating photosensitizer/antibacterial agent, into the polyurethane adhesive blend and coating the blend on co-electrospinning cellulose acetate(CA)/thermoplastic polyurethanes(TPU) composite membrane support for enhanced antibacterial performance. The central composite design (CCD) method based on the response surface method (RSM) was used for analysis to illustrate the influence of important variables. The optimized parameters of CCD were TPU (wt%) 22.64%, CA (wt%) 18.63, DMAC/acetone volume ratio 0.85, LiCl (wt%) 0.95%, voltage (kV) 23.33 kV. Fiber diameter was the key response process output variable. The membranes were characterized by SEM, XPS, and molecular structure analyses. The model had excellent applicability as a tool to realize the average diameter of the CA/TPU bicomponent electrospun membrane. Results showed that after coating, the synergistic effects of photodynamic antibacterial and antibacterial agent performance on the Antibacterial composite membrane were achieved under ordinary daylight irradiation. The sterilization rate of S. aureus and E. coli could achieve excellence at 99.2% and 93.4%, respectively. This method of preparing photodynamic antibacterial composite film provides a new direction for the design of medical antibacterial protective materials.
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The data presented in this study are available on request from the corresponding author.
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Acknowledgments
We would like to thank the Analytical and Testing Center of Tiangong University for the work related to the surface morphology and chemical structure of the composite fabric.
Funding
This work was supported by the National Natural Science Foundation of China (Grant Number 11702187), 2021 Tian** Postgraduate Research Innovation Project (Grant Number 2021YJSB235), Research Fund of China National Textile and Apparel Council (Grant Number 2022033).
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XH: designed the experiment, experimented, and wrote the manuscript. TTL: The corresponding author, Offered Suggestions for the experiments. LY, Y Z, BS: Assisted with the experiments, prepared figures and tables, polished the English language. HR: Offered suggestions for the characterizations of materials. JHorngL: Formal analysis, Offered Suggestions for the experiments. CWL: Corresponding author, critical revision of the article, final approval of the article.
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Hu, X., Li, TT., Yang, L. et al. Optimization, synthesis, and characterization of co-electrospinning cellulose acetate/thermoplastic polyurethanes composite membrane for photodynamic antibacterial application. Cellulose 30, 11701–11720 (2023). https://doi.org/10.1007/s10570-023-05572-3
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DOI: https://doi.org/10.1007/s10570-023-05572-3