Abstract
Heat-induced hormesis in longevity is the increase in life span resulting from the previous exposure to a mild heat stress early in life. Here we examined heat-induced hormesis of Drosophila buzzatii in five mass-mating populations, which were derived from five wild populations along an elevation gradient from 202 to 1855 m above sea level in North-Western Argentina. Five day old flies were exposed to 37.5 °C for 90 min to induce hormesis and its possible variation across altitudinal populations. This heat treatment strongly extended longevity in lowland-derived flies from the most heat-resistant population only. Both heat-induced effects on longevity and heat-knockdown time (heat-stress sensitivity) were negatively correlated to altitude of population of origin. Hormesis was positively correlated to heat-knockdown time across populations. These results indicate that variation in heat-induced hormesis can not be considered as independent of heat-stress sensitivity (or heat-knockdown time) in populations of insects.
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We have submitted phenotypic data as suppl material. All data will be made available on request.
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Acknowledgements
This work was supported by grants from Consejo Nacional de Investigaciones Científicas y Técnicas de Argentina (PIP 2021 GI 11220200100862CO), Agencia Nacional de Promoción Científica y Tecnológica (PICT-2017-1426) and Universidad de Buenos Aires to FMN.
Funding
National agency of scientific and technical promotion, Argentina, PICT-2017-1426, National council of scientific and technical research, PIP 2021 GI 11220200100862CO, Univertity of Buenos Aires, UBACyT 20020170100180BA.
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MA, FHG, PS and FMN performed all measurements of longevity. MA analysed data, prepared some figures and drafted a section of material and methods. FMN wrote the paper.
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Almirón, M., Gomez, F.H., Sambucetti, P. et al. Heat-induced hormesis in longevity is linked to heat-stress sensitivity across laboratory populations from diverse altitude of origin in Drosophila buzzatii. Biogerontology 25, 183–190 (2024). https://doi.org/10.1007/s10522-023-10066-7
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DOI: https://doi.org/10.1007/s10522-023-10066-7