SpringerLink
Log in

Endothelin Level in Menopausal Women with Comorbidity of the Acute Phase Middle Severity COVID-19 with Arterial Hypertension and Type 2 Diabetes Mellitus

  • IMMUNOLOGY AND MICROBIOLOGY
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

The levels of endothelins were assessed in menopausal women with arterial hypertension (AH) and type 2 diabetes mellitus (T2DM) in the acute phase of the moderate COVID-19. Women under observation (age 45-69 years) were divided into two groups. Control group consisted of women (n=16) who did not have COVID-19, were not vaccinated, and had no antibodies to SARS-CoV-2 (IgG). The main group included women (n=63) in the acute phase of the moderate COVID-19 accompanied by pneumonia. According to the clinical and anamnestic data analysis, the main group was divided into subgroups: without AH and T2DM (n=21); with AH and without T2DM (n=32); and with AH and T2DM (n=10). The parameters of clinical blood analysis, as well as endothelin-1, endothelin-2, and endothelin-3 levels were assessed. In women with a moderate COVID-19, the endothelin-1 and endothelin-2 levels were increased compared to the control regardless of AH and T2DM status. We found no statistically significant differences in the studied parameters of endothelial dysfunction between the subgroups of menopausal women in the acute phase of the moderate COVID-19.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price includes VAT (France)

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Prinelli F, Trevisan C, Noale M, Franchini M, Giacomelli A, Cori L, Jesuthasan N, Incalzi RA, Maggi S, Adorni F; EPICOVID19 Working Group. Sex- and gender-related differences linked to SARS-CoV-2 infection among the participants in the web-based EPICOVID19 survey: the hormonal hypothesis. Maturitas. 2022;158:61-69. https://doi.org/10.1016/j.maturitas.2021.11.015

  2. Scherbak SG, Kamilova TA, Golota AS, Vologzhanin DA. Risk factors of the severe course and fatal outcome in COVID-19. Fiz. Reabil. Med. Med. Reabil. 2022;4(1):14-36. Russian. https://doi.org/10.36425/rehab104997

  3. Xu SW, Ilyas I, Weng JP. Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies. Acta Pharmacol. Sin. 2023;44(4):695-709. https://doi.org/10.1038/s41401-022-00998-0

    Article  CAS  PubMed  Google Scholar 

  4. Al-Kuraishy HM, Al-Gareeb AI, Al-Niemi MS, Aljowaie RM, Almutairi SM, Alexiou A, Batiha GE. The Prospective Effect of Allopurinol on the Oxidative Stress Index and Endothelial Dysfunction in Covid-19. Inflammation. 2022;45(4):1651-1667. https://doi.org/10.1007/s10753-022-01648-7

    Article  CAS  PubMed  Google Scholar 

  5. Rychkova LV, Darenskaya MA, Semenova NV, Kolesnikov SI, Petrova AG, Nikitina OA, Brichagina AS, Kolesnikova LI. Oxidative Stress Intensity in Children and Adolescents with a New Coronavirus Infection. Int. J. Biomed. 2022;12(2):242-246. https://doi.org/10.21103/Article12(2)_OA7

  6. Semenova NV, Rychkova LV, Darenskaya MA, Kolesnikov SI, Nikitina OA, Petrova AG, Vyrupaeva EV, Kolesnikova LI. Superoxide Dismutase Activity in Male and Female Patients of Different Age with Moderate COVID-19. Bull. Exp. Biol. Med. 2022;173(1):51-53. https://doi.org/10.1007/s10517-022-05491-6

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Vyrupaeva EV, Semenova NV, Rychkova LV, Petrova AG, Darenskaya MA, Kolesnikov SI, Sambyalova AYu, Kolesnikova LI. Assessment of the general condition and quality of life of women of post-reproductive age after asymptomatic COVID-19 and 12 months after moderate COVID-19. Acta Biomedica Scientifica. 2022;7(5-1):77-85. Russian. https://doi.org/10.29413/ABS.2022-7.5-1.9

  8. Semenova NV, Kolesnikov SI, Vyrupaeva EV, Sholokhov LF, Rychkova LV, Petrova AG, Akhmedzyanova MR, Darenskaya MA, Kolesnikova LI. Thyroid status and TNF-alpha in post-reproductive women with COVID-19 and 12 months after the disease. Acta Biomedica Scientifica. 2023;8(2):33-42. Russian. https://doi.org/10.29413/ABS.2023-8.2.4

  9. Khimji AK, Rockey DC. Endothelin — biology and disease. Cell. Signal. 2010;22(11):1615-1625. https://doi.org/10.1016/j.cellsig.2010.05.002

    Article  CAS  PubMed  Google Scholar 

  10. Abraham GR, Kuc RE, Althage M, Greasley PJ, Ambery P, Maguire JJ, Wilkinson IB, Hoole SP, Cheriyan J, Davenport AP. Endothelin-1 is increased in the plasma of patients hospitalised with Covid-19. J. Mol. Cell. Cardiol. 2022;167:92-96. https://doi.org/10.1016/j.yjmcc.2022.03.007

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Groznova OS, Miklashevich IM, Voinova VYu, Shkolnikova MA, Tkacheva ON, Dudinskaya EN, Kovalev IA. Biomarkers of early cardiovascular aging. Ross. Vestn. Perinatol. Pediatr. 2019;64(4):11-18. Russian. https://doi.org/10.21508/1027-4065-2019-64-4-11-18

  12. Popykhova EB, Govorunova TV, Shirokov VYu, Ivanov AN. Sexual dimorphism of changes in adhesive properties of the vascular wall in the dynamics of conservative treatment of chronic generalized periodontitis. Parodontologiya. 2018;24(4):30-36. Russian. https://doi.org/10.25636/PMP.1.2018.4.6

  13. Kuznik BI, Smolyakov YuN, Shapovalov KG, Kazantseva LS, Chalisova NI. Eosinophils are predictors of susceptibility to thrombosis and severe course of COVID-19 in various types of therapy. Mol. Med. 2022;20(4):35-42. Russian. https://doi.org/10.29296/24999490-2022-04-06

  14. Darenskaya MA, Kolesnikova LI, Kolesnikov SI. Oxidative Stress: Pathogenetic Role in Diabetes Mellitus and Its Complications and Therapeutic Approaches to Correction. Bull. Exp. Biol. Med. 2021;171(2):179-189. https://doi.org/10.1007/s10517-021-05191-7

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Varga Z, Flammer AJ, Steiger P, Haberecker M, Andermatt R, Zinkernagel AS, Mehra MR, Schuepbach RA, Ruschitzka F, Moch H. Endothelial cell infection and endotheliitis in COVID-19. Lancet. 2020;395:1417-1418. https://doi.org/10.1016/S0140-6736(20)30937-5

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Scientific Center for Family Health and Human Reproduction Problems, Irkutsk, Russia

    N. V. Semenova, E. V. Vyrupaeva, S. I. Kolesnikov, O. A. Nikitina, L. V. Rychkova, M. A. Darenskaya, A. G. Petrova & L. I. Kolesnikova

Authors
  1. N. V. Semenova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. V. Vyrupaeva
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. I. Kolesnikov
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. O. A. Nikitina
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. L. V. Rychkova
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. M. A. Darenskaya
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. A. G. Petrova
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. L. I. Kolesnikova
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to N. V. Semenova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 176, No. 12, pp. 741-745, December, 2023

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Semenova, N.V., Vyrupaeva, E.V., Kolesnikov, S.I. et al. Endothelin Level in Menopausal Women with Comorbidity of the Acute Phase Middle Severity COVID-19 with Arterial Hypertension and Type 2 Diabetes Mellitus. Bull Exp Biol Med 176, 767–771 (2024). https://doi.org/10.1007/s10517-024-06105-z

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-024-06105-z

Keywords

Search

Navigation