SpringerLink
Log in

Development and validation of ferroptosis-related lncRNA signature and immune-related gene signature for predicting the prognosis of cutaneous melanoma patients

  • Published:
Apoptosis Aims and scope Submit manuscript

Abstract

Ferroptosis, a form of cell death caused by iron-dependent peroxidation of lipids, plays an important role in cancer. Recent studies have shown that long noncoding RNAs (lncRNAs) are involved in the regulation of ferroptosis in tumor cells and are also closely related to tumor immunity. Immune cell infiltration in the tumor microenvironment affects the prognosis and clinical outcome of immunotherapy in melanoma patients, and immune cell classification may be able to accurately predict the prognosis of melanoma patients. However, the prognostic value of ferroptosis-related lncRNAs (FRLs) in melanoma has not been thoroughly explored, and it is difficult to define the immune characteristics of melanoma. We used The Cancer Genome Atlas (TCGA), the Genotype-Tissue Expression (GTEx) database, and the FerrDb database to identify FRLs. FRLs with prognostic value were evaluated in an experimental cohort utilizing univariate, LASSO (least absolute shrinkage and selection operator) and multivariate Cox regression, followed by in vitro assays evaluating the expression levels and the biological functions of three candidate FRLs. Kaplan–Meier (K-M) and receiver operating characteristic (ROC) curve analyses were used to assess the validity of the risk model, and the drug sensitivity of FRLs was examined by drug sensitivity analysis. The differentially expressed genes between the high- and low-risk groups in the risk model were enriched in the immune pathway, and we further found immune gene signatures (IRGs) that could predict the prognosis of melanoma patients through a series of methods including single-sample Gene Set Enrichment Analysis (ssGSEA). Finally, two GEO cohorts were used to validate the predictive accuracy and reliability of these two signature models. Our findings suggest that FRLs and IRGs have the potential to predict the prognosis of patients with cutaneous melanoma.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9
Fig. 10
Fig. 11
Fig. 12

Similar content being viewed by others

Data availability

The data that support the findings of this study are available from the corresponding author upon request.

References

  1. Ferlay J, Colombet M, Soerjomataram I, Parkin DM, Piñeros M, Znaor A, Bray F (2021). Int J Cancer. https://doi.org/10.1002/ijc.33588

    Article  PubMed  Google Scholar 

  2. Laikova KV, Oberemok VV, Krasnodubets AM, Gal’chinsky NV, Useinov RZ, Novikov IA, Temirova ZZ, Gorlov MV, Shved NA, Kumeiko VV, Makalish TP, Bessalova EY, Fomochkina II, Esin AS, Volkov ME, Kubyshkin AV (2019). Molecules. https://doi.org/10.3390/molecules24081516

    Article  PubMed  PubMed Central  Google Scholar 

  3. Siegel RL, Miller KD, Jemal A (2020) CA Cancer J Clin 70:7–30. https://doi.org/10.3322/caac.21590

    Article  PubMed  Google Scholar 

  4. Strub T, Ballotti R, Bertolotto C (2020) Theranostics 10:1777–1797. https://doi.org/10.7150/thno.36218

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Sicco E, Mónaco A, Fernandez M, Moreno M, Calzada V, Cerecetto H (2021) Sci Rep 11:19942. https://doi.org/10.1038/s41598-021-98828-6

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Schadendorf D, van Akkooi ACJ, Berking C, Griewank KG, Gutzmer R, Hauschild A, Stang A, Roesch A, Ugurel S (2018) Lancet 392:971–984. https://doi.org/10.1016/s0140-6736(18)31559-9

    Article  PubMed  Google Scholar 

  7. Pilla L, Alberti A, Di Mauro P, Gemelli M, Cogliati V, Cazzaniga ME, Bidoli P, Maccalli C (2020). Cancers (Basel). https://doi.org/10.3390/cancers12113456

    Article  PubMed  Google Scholar 

  8. Johann K, Bohn T, Shahneh F, Luther N, Birke A, Jaurich H, Helm M, Klein M, Raker VK, Bopp T, Barz M, Becker C (2021) Nat Commun 12:5981. https://doi.org/10.1038/s41467-021-26269-w

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Zeng Y, Zeng Y, Yin H, Chen F, Wang Q, Yu X, Zhou Y (2021) Aging (Albany NY) 13:3459–3482. https://doi.org/10.18632/aging.202279

    Article  CAS  PubMed  Google Scholar 

  10. Galon J, Pagès F, Marincola FM, Thurin M, Trinchieri G, Fox BA, Gajewski TF, Ascierto PA (2012) J Transl Med 10:1. https://doi.org/10.1186/1479-5876-10-1

    Article  PubMed  PubMed Central  Google Scholar 

  11. Ros-Martínez S, Navas-Carrillo D, Alonso-Romero JL, Orenes-Piñero E (2020) Crit Rev Clin Lab Sci 57:432–443. https://doi.org/10.1080/10408363.2020.1729692

    Article  CAS  PubMed  Google Scholar 

  12. Keung EZ, Gershenwald JE (2020) J Natl Cancer Inst 112:875–885. https://doi.org/10.1093/jnci/djaa012

    Article  PubMed  PubMed Central  Google Scholar 

  13. Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS, Morrison B 3rd, Stockwell BR (2012) Cell 149:1060–1072. https://doi.org/10.1016/j.cell.2012.03.042

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Conrad M, Novikova M (2020) Signal Transduct Target Ther 5:261. https://doi.org/10.1038/s41392-020-00368-4

    Article  PubMed  PubMed Central  Google Scholar 

  15. Talty R, Bosenberg M (2022) Pigment Cell Melanoma Res 35:18–25. https://doi.org/10.1111/pcmr.13009

    Article  PubMed  Google Scholar 

  16. Ashrafizadeh M, Mohammadinejad R, Tavakol S, Ahmadi Z, Roomiani S, Katebi M (2019) J Cell Physiol 234:19471–19479. https://doi.org/10.1002/jcp.28740

    Article  CAS  PubMed  Google Scholar 

  17. Tsoi J, Robert L, Paraiso K, Galvan C, Sheu KM, Lay J, Wong DJL, Atefi M, Shirazi R, Wang X, Braas D, Grasso CS, Palaskas N, Ribas A, Graeber TG (2018) Cancer Cell 33:890-904.e895. https://doi.org/10.1016/j.ccell.2018.03.017

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Hangauer MJ, Viswanathan VS, Ryan MJ, Bole D, Eaton JK, Matov A, Galeas J, Dhruv HD, Berens ME, Schreiber SL, McCormick F, McManus MT (2017) Nature 551:247–250. https://doi.org/10.1038/nature24297

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Viswanathan VS, Ryan MJ, Dhruv HD, Gill S, Eichhoff OM, Seashore-Ludlow B, Kaffenberger SD, Eaton JK, Shimada K, Aguirre AJ, Viswanathan SR, Chattopadhyay S, Tamayo P, Yang WS, Rees MG, Chen S, Boskovic ZV, Javaid S, Huang C, Wu X, Tseng YY, Roider EM, Gao D, Cleary JM, Wolpin BM, Mesirov JP, Haber DA, Engelman JA, Boehm JS, Kotz JD, Hon CS, Chen Y, Hahn WC, Levesque MP, Doench JG, Berens ME, Shamji AF, Clemons PA, Stockwell BR, Schreiber SL (2017) Nature 547:453–457. https://doi.org/10.1038/nature23007

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Jiang Z, Lim SO, Yan M, Hsu JL, Yao J, Wei Y, Chang SS, Yamaguchi H, Lee HH, Ke B, Hsu JM, Chan LC, Hortobagyi GN, Yang L, Lin C, Yu D, Hung MC (2021). J Clin Invest. https://doi.org/10.1172/jci139434

    Article  PubMed  PubMed Central  Google Scholar 

  21. Wang W, Green M, Choi JE, Gijón M, Kennedy PD, Johnson JK, Liao P, Lang X, Kryczek I, Sell A, **a H, Zhou J, Li G, Li J, Li W, Wei S, Vatan L, Zhang H, Szeliga W, Gu W, Liu R, Lawrence TS, Lamb C, Tanno Y, Cieslik M, Stone E, Georgiou G, Chan TA, Chinnaiyan A, Zou W (2019) Nature 569:270–274. https://doi.org/10.1038/s41586-019-1170-y

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Liu Y, Zhang X, Zhang J, Tan J, Li J, Song Z (2020) Front Cell Dev Biol 8:596679. https://doi.org/10.3389/fcell.2020.596679

    Article  PubMed  PubMed Central  Google Scholar 

  23. Batista PJ, Chang HY (2013) Cell 152:1298–1307. https://doi.org/10.1016/j.cell.2013.02.012

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Wozniak M, Czyz M (2021). Cancers (Basel). https://doi.org/10.3390/cancers13194848

    Article  PubMed  PubMed Central  Google Scholar 

  25. Beroukhim R, Mermel CH, Porter D, Wei G, Raychaudhuri S, Donovan J, Barretina J, Boehm JS, Dobson J, Urashima M, Mc Henry KT, Pinchback RM, Ligon AH, Cho YJ, Haery L, Greulich H, Reich M, Winckler W, Lawrence MS, Weir BA, Tanaka KE, Chiang DY, Bass AJ, Loo A, Hoffman C, Prensner J, Liefeld T, Gao Q, Yecies D, Signoretti S, Maher E, Kaye FJ, Sasaki H, Tepper JE, Fletcher JA, Tabernero J, Baselga J, Tsao MS, Demichelis F, Rubin MA, Janne PA, Daly MJ, Nucera C, Levine RL, Ebert BL, Gabriel S, Rustgi AK, Antonescu CR, Ladanyi M, Letai A, Garraway LA, Loda M, Beer DG, True LD, Okamoto A, Pomeroy SL, Singer S, Golub TR, Lander ES, Getz G, Sellers WR, Meyerson M (2010) Nature 463:899–905. https://doi.org/10.1038/nature08822

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Beermann J, Piccoli MT, Viereck J, Thum T (2016) Physiol Rev 96:1297–1325. https://doi.org/10.1152/physrev.00041.2015

    Article  CAS  PubMed  Google Scholar 

  27. Wang Z, Chen X, Liu N, Shi Y, Liu Y, Ouyang L, Tam S, **ao D, Liu S, Wen F, Tao Y (2021) Mol Ther 29:263–274. https://doi.org/10.1016/j.ymthe.2020.09.024

    Article  CAS  PubMed  Google Scholar 

  28. **ng XL, Zhang T, Yao ZY, **ng C, Wang C, Liu YW, Huang M (2021) Front Genet 12:690053. https://doi.org/10.3389/fgene.2021.690053

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Petitprez F, Vano YA, Becht E, Giraldo NA, de Reyniès A, Sautès-Fridman C, Fridman WH (2018) Cancer Immunol Immunother 67:981–988. https://doi.org/10.1007/s00262-017-2058-z

    Article  PubMed  Google Scholar 

  30. Ladányi A (2015) Pigment Cell Melanoma Res 28:490–500. https://doi.org/10.1111/pcmr.12371

    Article  PubMed  Google Scholar 

  31. Selitsky SR, Mose LE, Smith CC, Chai S, Hoadley KA, Dittmer DP, Moschos SJ, Parker JS, Vincent BG (2019) Genome Med 11:36. https://doi.org/10.1186/s13073-019-0647-5

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Iglesia MD, Parker JS, Hoadley KA, Serody JS, Perou CM, Vincent BG (2016). J Natl Cancer Inst. https://doi.org/10.1093/jnci/djw144

    Article  PubMed  PubMed Central  Google Scholar 

  33. Zhou N, Bao J (2020). Database (Oxford). https://doi.org/10.1093/database/baaa021

    Article  PubMed  PubMed Central  Google Scholar 

  34. Jian Z, Li K, Song P, Zhu G, Zhu L, Cui T, Liu B, Tang L, Wang X, Wang G, Gao T, Li C (2014) J Invest Dermatol 134:2221–2230. https://doi.org/10.1038/jid.2014.152

    Article  CAS  PubMed  Google Scholar 

  35. Yoshihara K, Shahmoradgoli M, Martínez E, Vegesna R, Kim H, Torres-Garcia W, Treviño V, Shen H, Laird PW, Levine DA, Carter SL, Getz G, Stemke-Hale K, Mills GB, Verhaak RG (2013) Nat Commun 4:2612. https://doi.org/10.1038/ncomms3612

    Article  CAS  PubMed  Google Scholar 

  36. Newman AM, Liu CL, Green MR, Gentles AJ, Feng W, Xu Y, Hoang CD, Diehn M, Alizadeh AA (2015) Nat Methods 12:453–457. https://doi.org/10.1038/nmeth.3337

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. Tan Y, Zhang S, **ao Q, Wang J, Zhao K, Liu W, Huang K, Tian W, Niu H, Lei T, Shu K (2020) Genomics 112:4808–4816. https://doi.org/10.1016/j.ygeno.2020.08.035

    Article  CAS  PubMed  Google Scholar 

  38. Li T, Fan J, Wang B, Traugh N, Chen Q, Liu JS, Li B, Liu XS (2017) Cancer Res 77:e108–e110. https://doi.org/10.1158/0008-5472.Can-17-0307

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Cao JY, Dixon SJ (2016) Cell Mol Life Sci 73:2195–2209. https://doi.org/10.1007/s00018-016-2194-1

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. Yang WS, Stockwell BR (2016) Trends Cell Biol 26:165–176. https://doi.org/10.1016/j.tcb.2015.10.014

    Article  CAS  PubMed  Google Scholar 

  41. Ursini F, Maiorino M (2020) Free Radic Biol Med 152:175–185. https://doi.org/10.1016/j.freeradbiomed.2020.02.027

    Article  CAS  PubMed  Google Scholar 

  42. Skudalski L, Waldman R, Kerr PE, Grant-Kels JM (2022) J Am Acad Dermatol 86:515–524. https://doi.org/10.1016/j.jaad.2021.09.075

    Article  PubMed  Google Scholar 

  43. Siegel RL, Miller KD, Fuchs HE, Jemal A (2022) CA Cancer J Clin 72:7–33. https://doi.org/10.3322/caac.21708

    Article  PubMed  Google Scholar 

  44. Lu B, Chen XB, Ying MD, He QJ, Cao J, Yang B (2017) Front Pharmacol 8:992. https://doi.org/10.3389/fphar.2017.00992

    Article  CAS  PubMed  Google Scholar 

  45. Yang Y, Luo M, Zhang K, Zhang J, Gao T, Connell DO, Yao F, Mu C, Cai B, Shang Y, Chen W (2020) Nat Commun 11:433. https://doi.org/10.1038/s41467-020-14324-x

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  46. Friedmann Angeli JP, Krysko DV, Conrad M (2019) Nat Rev Cancer 19:405–414. https://doi.org/10.1038/s41568-019-0149-1

    Article  CAS  PubMed  Google Scholar 

  47. Mou Y, Wang J, Wu J, He D, Zhang C, Duan C, Li B (2019) J Hematol Oncol 12:34. https://doi.org/10.1186/s13045-019-0720-y

    Article  PubMed  PubMed Central  Google Scholar 

  48. Gupta PB, Pastushenko I, Skibinski A, Blanpain C, Kuperwasser C (2019) Cell Stem Cell 24:65–78. https://doi.org/10.1016/j.stem.2018.11.011

    Article  CAS  PubMed  Google Scholar 

  49. Wang M, Mao C, Ouyang L, Liu Y, Lai W, Liu N, Shi Y, Chen L, **ao D, Yu F, Wang X, Zhou H, Cao Y, Liu S, Yan Q, Tao Y, Zhang B (2020) Cell Death Differ 27:1447. https://doi.org/10.1038/s41418-019-0394-6

    Article  PubMed  Google Scholar 

  50. Xu Z, Peng B, Liang Q, Chen X, Cai Y, Zeng S, Gao K, Wang X, Yi Q, Gong Z, Yan Y (2021) Front Immunol 12:719175. https://doi.org/10.3389/fimmu.2021.719175

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  51. Zhang K, ** L, Du T, Liang G, Huang Y, Li Z, Deng R, Tang J (2021) Front Mol Biosci 8:678877. https://doi.org/10.3389/fmolb.2021.678877

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  52. He Y, Wang X (2020) Ann Transl Med 8:1050. https://doi.org/10.21037/atm-20-922

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  53. Ma Y, Wang N, Yang S (2022) Aging (Albany NY) 14:3030–3048. https://doi.org/10.18632/aging.203982

    Article  CAS  PubMed  Google Scholar 

  54. Sun S, Zhang G, Zhang L (2021) Front Cell Dev Biol 9:790047. https://doi.org/10.3389/fcell.2021.790047

    Article  PubMed  Google Scholar 

  55. Guo K, Qian K, Shi Y, Sun T, Wang Z (2021) Cell Death Dis 12:1097. https://doi.org/10.1038/s41419-021-04386-0

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  56. Wang P, Chen Y, Zheng Y, Fu Y, Ding Z (2021) Dis Markers 2021:5340240. https://doi.org/10.1155/2021/5340240

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  57. Hou J, Wang Z, Li H, Zhang H, Luo L (2022) J Oncol 2022:9332844. https://doi.org/10.1155/2022/9332844

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  58. Zhang X, Zhang Q, Liu G (2022) Front Genet 13:992444. https://doi.org/10.3389/fgene.2022.992444

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  59. Wang Y, Lu G, Xue X, **e M, Wang Z, Ma Z, Feng Y, Shao C, Duan H, Pan M, Ding P, Li X, Han J, Yan X (2022) Front Immunol 13:903758. https://doi.org/10.3389/fimmu.2022.903758

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  60. Long J, Liu L, Zhou X, Lu X, Qin L (2022) J Oncol 2022:7130634. https://doi.org/10.1155/2022/7130634

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  61. Zhong Q, Lu M, Yuan W, Cui Y, Ouyang H, Fan Y, Wang Z, Wu C, Qiao J, Hang J (2021) J Transl Med 19:58. https://doi.org/10.1186/s12967-021-02705-9

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  62. An J, Kim D, Oh B, Oh YJ, Song J, Park N, Kim HI, Kang HJ, Oh JH, Kim W, Lee E, Sung CO, Song GW, Kim DG, Yu E, Letouzé E, Zucman-Rossi J, Lee HC, Shim JH (2022) Hepatology 75:997–1011. https://doi.org/10.1002/hep.32135

    Article  CAS  PubMed  Google Scholar 

  63. Nazmeen A, Chen G, Maiti S (2020) Mol Biol Rep 47:4691–4698. https://doi.org/10.1007/s11033-020-05518-z

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  64. Liang W, Peng X, Li Q, Wang P, Lv P, Song Q, She S, Huang S, Chen K, Gong W, Yuan W, Thovarai V, Yoshimura T, O’Huigin C, Trinchieri G, Huang J, Lin S, Yao X, Bian X, Kong W, ** J, Wang JM, Wang Y (2020) Nat Commun 11:5912. https://doi.org/10.1038/s41467-020-19691-z

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  65. Wan ZH, Ma YH, Jiang TY, Lin YK, Shi YY, Tan YX, Dong LW, Wang HY (2019) Hepatobiliary Pancreat Dis Int 18:525–531. https://doi.org/10.1016/j.hbpd.2019.09.005

    Article  PubMed  Google Scholar 

  66. Andrews LP, Marciscano AE, Drake CG, Vignali DA (2017) Immunol Rev 276:80–96. https://doi.org/10.1111/imr.12519

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  67. Wang W, Min K, Chen G, Zhang H, Deng J, Lv M, Cao Z, Zhou Y (2021) J Cancer 12:5967–5976. https://doi.org/10.7150/jca.58768

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  68. Chernyakov D, Groß A, Fischer A, Bornkessel N, Schultheiss C, Gerloff D, Edemir B (2021) J Exp Clin Cancer Res 40:226. https://doi.org/10.1186/s13046-021-01982-y

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  69. Wang C, Cicek MS, Charbonneau B, Kalli KR, Armasu SM, Larson MC, Konecny GE, Winterhoff B, Fan JB, Bibikova M, Chien J, Shridhar V, Block MS, Hartmann LC, Visscher DW, Cunningham JM, Knutson KL, Fridley BL, Goode EL (2014) Cancer Res 74:3084–3091. https://doi.org/10.1158/0008-5472.Can-13-3198

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  70. Meng Q, Hu X, Zhao X, Kong X, Meng YM, Chen Y, Su L, Jiang X, Qiu X, Huang C, Liu C, Wang M, Wong PP (2021) EBioMedicine 66:103301. https://doi.org/10.1016/j.ebiom.2021.103301

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  71. Su Q, Wang Y, Zhao J, Ma C, Wu T, ** T, Xu J (2015) BMC Gastroenterol 15:107. https://doi.org/10.1186/s12876-015-0336-9

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  72. Guo S, Chen J, Yi X, Lu Z, Guo W (2022) Front Immunol 13:985051. https://doi.org/10.3389/fimmu.2022.985051

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  73. ** S, Gong R, Lei K, Qing G, Zhang G, Chen J (2022) Discov Oncol 13:125. https://doi.org/10.1007/s12672-022-00581-3

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

This work was supported by the National Natural Science Foundation of China (82073019 and 82073018), Hunan Provincial Natural Science Foundation of China (under grant 2022JJ30189), Teaching Reform Research Project of Universities in HunanProvince (under grant HNJG-2021-1120), and Shenzhen Science and Technology Innovation Commission, China (Natural Science Foundation of Shenzhen, JCYJ20210324113001005 and JCYJ20210324114212035).

Author information

Authors and Affiliations

  1. Department of Dermatology, **angya Hospital, Central South University, Changsha, Hunan, 410008, China

    Kaifen **ong

  2. School of Computer Science, Hunan First Normal University, Changsha, 410205, China

    Zheng Wang & Li Peng

  3. School of Mathematics and Statistics, Central South University, Changsha, 410083, China

    Alphonse Houssou Hounye

  4. Department of Dermatology, Shenzhen People’s Hospital (The Second Clinical Medical College, **an University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, 518020, Guangdong, China

    Jianglin Zhang

  5. Candidate Branch of National Clinical Research Center for Skin Diseases, Shenzhen, 518020, Guangdong, China

    Jianglin Zhang

  6. Department of Geriatrics, Shenzhen People’s Hospital(The Second Clinical Medical College, **an UniversityThe First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, 518020, Guangdong, China

    Jianglin Zhang

  7. Department of Plastic Surgery, **angya Hospital, Central South University, Changsha, 410008, China

    Min Qi

Authors
  1. Kaifen **ong
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Zheng Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Alphonse Houssou Hounye
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Li Peng
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Jianglin Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Min Qi
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

Conception and design: Kaifen **ong; Financial support: Min Qi, Zheng Wang and Jianglin Zhang; Administrative support: Li Peng, Min Qi, and Jianglin Zhang; Collection and assembly of data: Kaifen **ong Alphonse Houssou Hounye, and Li Peng; Data analysis and interpretation: Kaifen **ong, Zheng Wang, and Alphonse Houssou Hounye; Manuscript writing: All authors; Final approval of manuscript: All authors; accountable for all aspects of the work: All authors.

Corresponding authors

Correspondence to Li Peng, Jianglin Zhang or Min Qi.

Ethics declarations

Conflict of interest

The concepts and information presented in this paper are based on research and are not commercially available. There are no conflicts to declare.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary Information

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

**ong, K., Wang, Z., Hounye, A.H. et al. Development and validation of ferroptosis-related lncRNA signature and immune-related gene signature for predicting the prognosis of cutaneous melanoma patients. Apoptosis 28, 840–859 (2023). https://doi.org/10.1007/s10495-023-01831-7

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10495-023-01831-7

Keywords

Search

Navigation