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A hierarchical conditional random field-based attention mechanism approach for gastric histopathology image classification

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Abstract

In the Gastric Histopathology Image Classification (GHIC) tasks, which are usually weakly supervised learning missions, there is inevitably redundant information in the images. Therefore, designing networks that can focus on distinguishing features has become a popular research topic. In this paper, to accomplish the tasks of GHIC superiorly and assist pathologists in clinical diagnosis, an intelligent Hierarchical Conditional Random Field based Attention Mechanism (HCRF-AM) model is proposed. The HCRF-AM model consists of an Attention Mechanism (AM) module and an Image Classification (IC) module. In the AM module, an HCRF model is built to extract attention regions. In the IC module, a Convolutional Neural Network (CNN) model is trained with the attention regions selected, and then an algorithm called Classification Probability-based Ensemble Learning is applied to obtain the image-level results from the patch-level output of the CNN. In the experiment, a classification specificity of 96.67% is achieved on a gastric histopathology dataset with 700 images. Our HCRF-AM model demonstrates high classification performance and shows its effectiveness and future potential in the GHIC field. In addition, the AM module and transfer learning technique allow the network to generalize well to other types of image data except histopathology images, and we obtain 95.5% and 95.8% accuracies on IG02 and Oxford-IIIT Pet Datasets.

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Acknowledgements

This study was supported by the National Natural Science Foundation of China (grant No. 61806047). We thank Miss **ran Wu, due to her contribution is considered as important as the first author in this paper. We thank M.D. **aoyan Li, due to her contribution is considered as important as the corresoponding author in this paper. We thank Miss Zixian Li and Mr. Guoxian Li for their important discussion. We also thank B.E. Haoyuan Chen for his help in the experiments.

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  1. Microscopic Image and Medical Image Analysis Group, College of Medicine and Biological Information Engineering, Northeastern University, Shenyang, China

    Yixin Li, **nran Wu, Chen Li, Haoyuan Chen, Changhao Sun & Md Mamunur Rahaman

  2. Liaoning Cancer Hospital and Institute, China Medical University, Shenyang, China

    **aoyan Li & Yong Zhang

  3. Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, China

    Changhao Sun

  4. Department of Electrical and Computer Engineering, Stevens Institute of Technology, Hoboken, NJ, 07030, USA

    Yudong Yao

  5. Control Engineering College, Chengdu University of Information Technology, Chengdu, People’s Republic of China

    Tao Jiang

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  1. Yixin Li
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Li, Y., Wu, X., Li, C. et al. A hierarchical conditional random field-based attention mechanism approach for gastric histopathology image classification. Appl Intell 52, 9717–9738 (2022). https://doi.org/10.1007/s10489-021-02886-2

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