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Fused Deposition Modeling 3D-Printed Scaffolds for Bone Tissue Engineering Applications: A Review

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Abstract

The emergence of bone tissue engineering as a trend in regenerative medicine is forcing scientists to create highly functional materials and scaffold construction techniques. Bone tissue engineering uses 3D bio-printed scaffolds that allow and stimulate the attachment and proliferation of osteoinductive cells on their surfaces. Bone grafting is necessary to expedite the patient’s condition because the natural healing process of bones is slow. Fused deposition modeling (FDM) is therefore suggested as a technique for the production process due to its simplicity, ability to create intricate components and movable forms, and low running costs. 3D-printed scaffolds can repair bone defects in vivo and in vitro. For 3D printing, various materials including metals, polymers, and ceramics are often employed but polymeric biofilaments are promising candidates for replacing non-biodegradable materials due to their adaptability and environment friendliness. This review paper majorly focuses on the fused deposition modeling approach for the fabrication of 3D scaffolds. In addition, it also provides information on biofilaments used in FDM 3D printing, applications, and commercial aspects of scaffolds in bone tissue engineering.

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences and Technology, Maharaja Ranjit Singh Punjab Technical University, Bathinda, 151001, India

    Pawan Kumar, Jyoti Bala & Amit Bhatia

  2. IIMT College of Medical Sciences, IIMT University, Ganga Nagar, Meerut, Uttar Pradesh, 250001, India

    Shamim

  3. Department of Pharmacology, Praduman Singh Sikshan Prasikshan Sansthan Pharmacy College, Phutahiya Sansarpur, Basti, Uttar Pradesh, 272001, India

    Mohammad Muztaba

  4. Department of Pharmacy, Swami Vivekanand Subharti University, Subhartipuram, Meerut, Uttar Pradesh, 250005, India

    Tarmeen Ali

  5. Department of Mechanical Engineering, Giani Zail Singh Campus College of Engineering & Technology, Maharaja Ranjit Singh Punjab Technical University, Bathinda, 151001, India

    Haramritpal Singh Sidhu

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  1. Pawan Kumar
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PK: Conception and writing of the manuscript. S, MM, and TA: Writing and validation. JB and HSS: Validation and writing. AB: Writing and drafting.

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Kumar, P., Shamim, Muztaba, M. et al. Fused Deposition Modeling 3D-Printed Scaffolds for Bone Tissue Engineering Applications: A Review. Ann Biomed Eng 52, 1184–1194 (2024). https://doi.org/10.1007/s10439-024-03479-z

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