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Severe inflammation associated with synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome was markedly ameliorated by single use of minocycline

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Modern Rheumatology

Abstract

We describe the case of a 63-year-old female who presented with severe inflammatory spondylitis, refractory to various antibiotics. Mycobacterial and fungal osteomyelitis were unlikely. Although asymptomatic, she also had osteomyelitis in the sternocostoclavicular region, and was suspected of having synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome, against which minocycline showed marked efficacy. The presence of severe inflammatory SAPHO, albeit rare, together with the marked efficacy of tetracycline, should be noted.

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Conflict of interest

The authors declare that there is no conflict of interest.

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Authors and Affiliations

  1. Department of Allergy and Immunological Diseases, Tokyo Metropolitan Komagome Hospital, Honkomagome 3-18-22, Bunkyo Ward, Tokyo, 1130021, Japan

    Yasunobu Takizawa, Atsuko Murota & Keigo Setoguchi

  2. Department of Orthopedics, Kyosai Tachikawa Hospital, 4-2-22 Nishikicho, Tachikawa, Tokyo, 190-8531, Japan

    Yoshihisa Suzuki

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  1. Yasunobu Takizawa
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  2. Atsuko Murota
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  3. Keigo Setoguchi
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  4. Yoshihisa Suzuki
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Correspondence to Yasunobu Takizawa.

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Takizawa, Y., Murota, A., Setoguchi, K. et al. Severe inflammation associated with synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome was markedly ameliorated by single use of minocycline. Mod Rheumatol (2013). https://doi.org/10.1007/s10165-013-0843-x

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