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Serum level of soluble triggering receptor expressed on myeloid cells-1 as a biomarker of disease activity in relapsing polychondritis

  • Original Article
  • Published:
Modern Rheumatology

Abstract

Objectives

We aimed to identify a serum biomarker for evaluating the disease activity of relapsing polychondritis (RP).

Methods

We measured and compared serum levels of 28 biomarkers potentially associated with this disease, including soluble triggering receptor expressed on myeloid cells-1 (sTREM-1), high-sensitivity C-reactive protein (hs-CRP), and cartilage oligomeric matrix protein (COMP), in 15 RP patients and 16 healthy donors (HDs). We divided the 15 RP patients into active RP (n = 8) and inactive RP (n = 7) groups, depending on the extent of the disease, and compared candidate markers between groups. The localization of membrane-bound TREM-1 in the affected tissue was examined by immunohistochemistry.

Results

Serum levels of sTREM-1, interferon-γ, chemokine (C–C motif) ligand 4, vascular endothelial growth factor, and matrix metalloproteinases-3 were significantly higher in RP patients than HDs. Among these markers, sTREM-1 had the highest sensitivity and specificity (86.7 and 86.7 %, respectively). Furthermore, the serum level of sTREM-1 was significantly higher in active RP patients than inactive RP patients (p = 0.0403), but this was not true for hs-CRP or COMP. TREM-1 was expressed on endothelial cells in RP lesions.

Conclusions

The serum level of sTREM-1 may be a useful marker of disease activity in RP.

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Acknowledgments

We would like to thank Katsunori Takahashi, Yasuo Kunitomo, Yuji Sato, Mikako Koike, and Yumiko Hasegawa for their excellent technical help. This study was supported by a Grant-in-Aid for Scientific Research from the Ministry of Health, Labour and Welfare, Japan.

Conflict of interest

None.

Author information

Authors and Affiliations

  1. Institute of Medical Science, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki, 216-8512, Japan

    Tomoo Sato, Yoshihisa Yamano, Yukiko Shimizu, Hitoshi Ando & Kazuo Yudoh

  2. Department of Pathology, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita-ku, Sapporo, 060-8638, Japan

    Utano Tomaru

  3. Division of Rheumatology and Allergy, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki, 216-8512, Japan

    Takahiro Okazaki, Hiroko Nagafuchi & Shoichi Ozaki

  4. Departments of Immunology and Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki, 216-8512, Japan

    Jun Shimizu & Noboru Suzuki

  5. Division of Respiratory and Infectious Diseases, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki, 216-8512, Japan

    Teruomi Miyazawa

  6. Rheumatic Disease Center, Tokyo Medical University Hachioji Medical Center, 1163 Tate-machi, Hachioji, 193-0998, Japan

    Hiroshi Oka

Authors
  1. Tomoo Sato
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  2. Yoshihisa Yamano
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  3. Utano Tomaru
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  4. Yukiko Shimizu
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  6. Takahiro Okazaki
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  7. Hiroko Nagafuchi
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  8. Jun Shimizu
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  9. Shoichi Ozaki
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  10. Teruomi Miyazawa
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  11. Kazuo Yudoh
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  12. Hiroshi Oka
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  13. Noboru Suzuki
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Corresponding author

Correspondence to Noboru Suzuki.

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Sato, T., Yamano, Y., Tomaru, U. et al. Serum level of soluble triggering receptor expressed on myeloid cells-1 as a biomarker of disease activity in relapsing polychondritis. Mod Rheumatol (2013). https://doi.org/10.1007/s10165-013-0833-z

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  • DOI: https://doi.org/10.1007/s10165-013-0833-z

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