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Incidence of acute kidney injury and decreased estimated glomerular filtration rate according to the site of cancer

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Abstract

Background

The epidemiology of renal impairment in patients with cancer remains unclear. We aimed to clarify associations between various cancer sites and renal impairment.

Methods

We reviewed data from 5674 patients aged ≥ 18 years receiving cancer treatment at a single hospital facility. The primary endpoints were the occurrence of acute kidney injury (AKI), a 30% decrease in the estimated glomerular filtration rate (eGFR), or death. Survival time was defined as the time from study enrolment to AKI occurrence. Kaplan–Meier and Cox proportional hazard analyses were performed.

Results

Hazard ratios (HRs) for AKI occurrence and a ≥ 30% decline in eGFR were significantly higher for kidney, urinary tract, pancreatic, liver, and gallbladder cancers than for colon cancer. Compared with colon cancer, digestive tract cancer showed a significantly higher HR for AKI occurrence alone. The HRs for a ≥ 30% decline in eGFR were significantly higher for patients aged 71‒77 years or ≥ 78 years than for those aged < 68 years, and for patients with eGFR ≥ 90 mL/min/1.73 m2 or 30–44 mL/min/1.73 m2 than for those with eGFR = 45‒59 mL/min/1.73 m2.

Conclusions

Kidney, urinary, hepatobiliary, or pancreatic cancer are associated with a higher risk of AKI development and eGFR decrease than other cancers. Renal function changes should be more closely monitored in patients with these cancers.

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Data availability

All data supporting our findings are contained within the manuscript.

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Acknowledgements

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Author information

Author notes

  1. Yutaka Hatakeyama and Taro Horino have contributed equally to this work.

Authors and Affiliations

  1. Center of Medical Information Science, Kochi Medical School, Kochi University, Kohasu, Oko-Cho, Nankoku, Kochi, 783-8505, Japan

    Yutaka Hatakeyama, Shigehiro Yasui & Yoshiyasu Okuhara

  2. Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi University, Kohasu, Oko-Cho, Nankoku, Kochi, 783-8505, Japan

    Taro Horino & Yoshio Terada

  3. Department of Otolaryngology, Kochi Medical School, Kochi University, Oko-Cho, Nankoku, Kohasu, Kochi, 783-8505, Japan

    Masahiro Komori

Authors
  1. Yutaka Hatakeyama
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  2. Taro Horino
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  3. Shigehiro Yasui
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  4. Masahiro Komori
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  6. Yoshiyasu Okuhara
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Contributions

YH, TH, and SY conceptualised and designed the study and did the literature search. All authors collected and interpreted the data and wrote and revised the manuscript. All authors have full access to the full data in the study and accept responsibility to submit it for publication. YH, TH, and SY had access to the raw data and verified it. Each author contributed important intellectual content during manuscript drafting or revision and agrees to be personally accountable for the individual’s own contributions and to ensure that questions pertaining to the accuracy or integrity of any portion of the work, even one in which the author was not directly involved, are appropriately investigated and resolved, including with documentation in the literature if appropriate.

Corresponding author

Correspondence to Taro Horino.

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Hatakeyama, Y., Horino, T., Yasui, S. et al. Incidence of acute kidney injury and decreased estimated glomerular filtration rate according to the site of cancer. Clin Exp Nephrol 27, 262–271 (2023). https://doi.org/10.1007/s10157-022-02303-z

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  • DOI: https://doi.org/10.1007/s10157-022-02303-z

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