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Predictors of early and late postoperative seizures in meningioma patients: a systematic review and meta-analysis

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Abstract

Meningioma is the most common type of primary brain tumor which presents with a variety of neurological manifestations. Surgical resection tends to be the preferred treatment. The occurrence of seizures after resection is common, which occur either early, within seven days of operation, or late. Our meta-analysis investigated the possible predictors of early and late postoperative seizures. We assessed the relevant observational studies on predictors of postoperative seizures published in PubMed, Scopus, and Web of Science from January 2000 to September 2022, and those that met inclusion criteria were included. We calculated the association between potential predicting factors and postoperative seizures, odds ratios (ORs) with 95% confidence intervals (CIs) applying either random or fixed-effect models. The early and late postoperative seizures were evaluated individually. Thirteen observational studies involving 4176 patients were included. Seizures occurred in 250 (6%) and 584 (14%) patients, respectively, in the early and late postoperative phases. Shared predictors for early and late seizures included tumors involving the motor cortex (OR = 2.7; 95% CI: 1.67–4.38, OR = 2.46; 95% CI: 1.68–3.61), postoperative neurological deficit (OR = 4.68; 95% CI: 2.67–8.22, OR = 2.01; 95% CI: 1.39–2.92), and preoperative seizures (OR = 2.52; 95% CI: 1.82–3.49, OR = 4.35; 95% CI: 3.29–5.75). Peritumoral edema (OR = 1.99; 95% CI: 1.49–2.64) was a significant factor only among late postoperative seizure patients while surgical complications (OR = 3.77; 95% CI: 2.39–5.93) was a significant factor solely for early postoperative seizures. Meningioma patients commonly experience early and late postoperative seizures. Identifying predictors of postoperative seizures is essential to diagnose and manage them effectively.

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Funding

The authors state that they did not receive any funds, grants, or any form of financial support while working on this manuscript.

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Authors and Affiliations

  1. Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan

    Alina Ghazou, Ahmed S. Aljabali, Yazan S. Al-Zamer, Mohmmad Alawajneh, Ashaar Al-Akhras, Majd M. AlBarakat, Shaden Tashtoush, Omar Shammout, Sami S. Al-Horani, Eman E. Jarrah & Obada Ababneh

  2. Department of Neurology, Jordan University of Science and Technology, Irbid, Jordan

    Ahmed Yassin

  3. Department of Neurosurgery, Jordan University of Science and Technology, Irbid, Jordan

    Amer Jaradat

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  1. Alina Ghazou
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  2. Ahmed Yassin
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  3. Ahmed S. Aljabali
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Contributions

A.G. and A.Y. conceived and designed the study. M.A. and O.S. performed the systematic search. A.A., S.T., E.E.J., and M.M.A. extracted the date. Y.S.A., A.G., M.A., O.A. assessed the literature quality. A.S.A. performed statistical analyses. A.G., S.S.A., A.S.A, M.A., and M.M.A drafted the main manuscript. A.Y, A.G., Y.S.A., A.S.A., and A.J. edited the manuscript. A.Y. and A.J. supervised the study. All authors reviewed the manuscript and approved its final version.

Corresponding author

Correspondence to Alina Ghazou.

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Patients' informed  consent and ethical approval were waived since we collected data from previously published studies with no recruited patients.

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The abstract of this manuscript was presented as an E-POSTER in the 2023 American Association of Neurological Surgeons Annual Scientific Meeting (AANS), which was held in Los Angeles, April 21 – April 24, 2023.

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Ghazou, A., Yassin, A., Aljabali, A.S. et al. Predictors of early and late postoperative seizures in meningioma patients: a systematic review and meta-analysis. Neurosurg Rev 47, 242 (2024). https://doi.org/10.1007/s10143-024-02487-w

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