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Correction to: Gastric Cancer (2021) 24:1242–1253 https://doi.org/10.1007/s10120-021-01202-8
In the original publication of the article, Figs. 2 and 5 were published with errors. The correct figures are published in this correction.
Macrophages are essential for the tumor-promoting effect of P. acnes. A Cholecystokinin octapeptide (CCK8) was used to assay the proliferation of SGC-7901. P. acnes or condition medium (CM) from P. acnes-primed macrophages did not affect the proliferation of SGC-7901. B–E Migration of SGC-7901 was investigated by wound healing assay. B, D P. acnes and E. coli DH5α did not affect the migration of SGC-7901 at 6h, 12h, and 24h. C, E Migration of SGC7901 significantly increased after stimulation with CM from P. acnes-primed macrophages at 12h and 24h. F–J Migration of SGC-7901 was determined by trans-well assay. F, H Compared with the untreated group, the migration of SGC-7901 enhanced after directly stimulated with P. acnes and E. coli DH5α, while no difference was found between GC cells stimulated with P. acnes and E. coli DH5α. G, I Migration of SGC-7901 was determined after stimulation with CM from THP-1 derived macrophage (control), and CM from P. acnes and E. coli DH5α-primed macrophages. CM from P. acnes-primed macrophages greatly promoted migration of SGC-7901. J CM from P. acnes-primed macrophages greatly enhanced migration of SGC7901 compared to P. acnes alone. ns, no significance; #P < 0.05 compared to untreated group; ## P < 0.01 compared to untreated group; ### P < 0.001 compared to untreated group; ★P < 0.05 compared to control group; ★★★P < 0.001 compared to control group. **P < 0.01. CM, condition medium
P. acnes promote M2 polarization of macrophages through TLR4/PI3K/Akt signaling. A–C Immunofuorescence was performed to analyze the polarization of P. acnes primed macrophages after PI3K blockade by LY294002. Scale bar, 20 μm. B Number of CD206+(M2) macrophages decreased at 12 h in P. acnes-primed macrophages pretreated with LY294002. C Number of CD86+(M1) macrophages increased in P. acnes-primed macrophages pretreated with LY294002. D mRNA levels of IL-10 and CCR-2 were signifcantly reduced after PI3K blockade. E Expression of TLR4, PI3K, p-Akt, and Akt was analyzed by western blotting assays. F Expression of PI3K and p-Akt increased in THP-1 derived macrophages stimulated with P. acnes. G The expression of PI3K and p-Akt decreased in P. acnes-primed macrophages pretreated with TAK-242. ns no signifcance; *P 0.05, **P 0.01, ***P 0.001
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Li, Q., Wu, W., Gong, D. et al. Correction to: Propionibacterium acnes overabundance in gastric cancer promote M2 polarization of macrophages via a TLR4/PI3K/Akt signaling. Gastric Cancer 25, 1139–1141 (2022). https://doi.org/10.1007/s10120-022-01339-0
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DOI: https://doi.org/10.1007/s10120-022-01339-0