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Diagnosis at the microscope: a workplace study of histopathology

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Abstract

Histopathologists diagnose cancer and other diseases by using a microscope to examine glass slides containing thin sections of human tissue. Technological advances mean that it is now possible to digitise the slides so that they can be viewed on a computer, promising a number of benefits in terms of both efficiency and safety. Despite this, uptake of digital microscopy for diagnostic work has been slow, and research suggests scepticism and uncertainty amongst histopathologists. In order to design a successful digital microscope, one which fits with the work practices of histopathologists and which they are happy to use within their daily work, we have undertaken a workplace study of a histopathology department. In this paper, we present the findings of that study and discuss the implications of these findings for the design of a digital microscope. The findings emphasise the way in which a diagnosis is built up as particular features on the glass slides are noticed and highlighted and the various information sources that are drawn on in the process of making a diagnosis.

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References

  • Axelrod L, Fitzpatrick G, Burridge J, Mawson S, Smith PP, Rodden T, Ricketts I (2009) The reality of homes fit for heroes: design challenges for rehabilitation technology at home. J Assist Technol 3(2):35–43

    Article  Google Scholar 

  • Blake CA, Lavoie HA, Millette CF (2003) Teaching medical histology at the University of South Carolina School of Medicine: Transition to virtual slides and virtual microscopes. Anat Rec B New Anat 275B(1):196–206

    Article  Google Scholar 

  • Buttfield-Addison P, Lueg C, Manning J (2009) The pile of least effort: supporting lived document management practices. Proceedings of the 21st annual conference of the australian computer-human interaction special interest group: design: open 24/7. Melbourne, Australia, ACM, pp 345–348

  • Ciolfi L (2004) Understanding spaces as places: extending interaction design paradigms. Cogn Technol Work 6(1):37–40

    Article  Google Scholar 

  • Clark D, Chomyn M (2010) lean thinking for histopathology (2): “Just in Time” Workload Allocation for Consultants acp News, pp 31–33

  • Cross SS, Dennis T, Start RD (2002) Telepathology: current status and future prospects in diagnostic histopathology. Histopathology 41(2):91–109

    Article  Google Scholar 

  • Crowley RS, Naus GJ, Stewart J III, Friedman CP (2003) Development of visual diagnostic expertise in pathology: an information-processing study. J Am Med Inform Assoc 10(1):39–51

    Article  Google Scholar 

  • Della Mea V, Demichelis F, Viel F, Dalla Palma P, Beltrami CA (2006) User attitudes in analyzing digital slides in a quality control test bed: a preliminary study. Comput Methods Programs Biomed 82(2):177–186

    Article  Google Scholar 

  • Dennis T, Start RD, Cross SS (2005) The use of digital imaging, video conferencing, and telepathology in histopathology: a national survey. J Clin Pathol 58(3):254–258

    Article  Google Scholar 

  • Emerson R, Fretz R, Shaw L (1995) Writing ethnographic fieldnotes. University of Chicago Press, Chicago

    Google Scholar 

  • Fandel T, Pfnür M, Schäfer S, Bacchetti P, Mast F, Corinth C, Ansorge M, Melchior S, Thüroff J, Kirkpatrick C, Lehr H-A (2008) Do we truly see what we think we see? The role of cognitive bias in pathological interpretation. J Pathol 216(2):193–200

    Article  Google Scholar 

  • Forsythe DE (1999) “It’s Just a Matter of Common Sense”: ethnography as invisible work. Comput Support Coop Work 8(1–2):127–145

    Article  Google Scholar 

  • Furness P (2007) A randomized controlled trial of the diagnostic accuracy of internet-based telepathology compared with conventional microscopy. Histopathology 50(2):266–273

    Article  Google Scholar 

  • Gilbertson J, Ho J, Anthony L, Jukic D, Yagi Y, Parwani A (2006) Primary histologic diagnosis using automated whole slide imaging: a validation study. BMC Clin Pathol 6(1):4

    Article  Google Scholar 

  • Goyal N, Jain N, Rachapalli V (2009) Ergonomics in radiology. Clin Radiol 64(2):119–126

    Article  Google Scholar 

  • Hamilton PW, van Diest PJ, Williams R, Gallagher AG (2009) Do we see what we think we see? The complexities of morphological assessment. J Pathol 218(3):285–291

    Article  Google Scholar 

  • Heath C, Luff P (2000) Technology in action. Cambridge University Press, Cambridge

    Book  Google Scholar 

  • Krupinski EA, Tillack AA, Richter L, Henderson JT, Bhattacharyya AK, Scott KM, Graham AR, Descour MR, Davis JR, Weinstein RS (2006) Eye-movement study and human performance using telepathology virtual slides. Implications for medical education and differences with experience. Hum Pathol 37(12):1543–1556

    Article  Google Scholar 

  • Kumar RK, Velan GM, Korell SO, Kandara M, Dee FR, Wakefield D (2004) Virtual microscopy for learning and assessment in pathology. J Pathol 204(5):613–618

    Article  Google Scholar 

  • Luff P, Hindmarsh J, Heath C (eds) (2000) Workplace studies: recovering work practice and informing system design. Cambridge University Press, Cambridge

    Google Scholar 

  • Meijer GA, Oudejans JJ, Koevoets JJM, Meijer CJLM (2009) Activity-based differentiation of pathologists’ workload in surgical pathology. Virchows Arch 454:623–628

    Article  Google Scholar 

  • Microsoft (2010) Design guidance–patient list view

  • Nakhleh RE (2008) Patient safety and error reduction in surgical pathology. Arch Pathol Lab Med 132:181–185

    Google Scholar 

  • QSR International. NVivo 8. http://www.qsrinternational.com

  • Rullo A (2008) The soft qualities of interaction. ACM Trans Comput Hum Interact 15(4):1–25

    Article  Google Scholar 

  • Tiersma ESM, Peters AAW, Mooij HA, Fleuren GJ (2003) Visualising scanning patterns of pathologists in the grading of cervical intraepithelial neoplasia. J Clin Pathol 56(9):677–680

    Article  Google Scholar 

  • Treanor D, Lim CH, Magee D, Bulpitt A, Quirke P (2009) Tracking with virtual slides: a tool to study diagnostic error in histopathology. Histopathology 55(1):37–45

    Article  Google Scholar 

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Acknowledgments

We are very grateful to all the histopathologists at Leeds Teaching Hospitals NHS Trust who enabled us to undertake this work by allowing us to observe them. We would like to thank Professor Phil Quirke for his feedback on this paper. This report is independent research commissioned by the National Institute for Health Research. The views expressed in this publication are those of the authors and not necessarily those of the NHS, the National Institute for Health Research or the Department of Health. The authors acknowledge the support of the National Institute for Health Research, through the Comprehensive Clinical Research Network.

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Correspondence to Rebecca Randell.

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Randell, R., Ruddle, R.A., Thomas, R. et al. Diagnosis at the microscope: a workplace study of histopathology. Cogn Tech Work 14, 319–335 (2012). https://doi.org/10.1007/s10111-011-0182-7

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