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Clinical significance and outcomes of Clostridium tertium bacteremia: analysis of 62 cases in neutropenic and non-neutropenic patients

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Abstract

The clinical significance of Clostridium tertium bacteremia is still uncertain. We evaluated the incidence, clinical characteristics, and outcomes of C. tertium bacteremia and identified differences between neutropenia and non-neutropenia. All adult patients with C. tertium bacteremia in a 2700-bed tertiary center between January 2004 and November 2021 were retrospectively enrolled. The first episode of C. tertium bacteremia in each patient was included in the analysis. Among 601 patients with Clostridium species bacteremia, 62 (10%) had C. tertium bacteremia, and of these 62 patients, 39 (63%) had had recent chemotherapy, and 31 (50%) had neutropenia or hematologic malignancy. C. tertium bacteremia originated frequently from a gastrointestinal tract infection such as enterocolitis (34%), primary bacteremia (29%), and secondary peritonitis (18%), and 34% of patients had polymicrobial bacteremia. Hematologic malignancy, prior antibiotic treatment, neutropenic enterocolitis, and primary bacteremia were significantly associated with C. tertium bacteremia in neutropenic patients, whereas solid tumor, hepatobiliary disease, secondary peritonitis, polymicrobial bacteremia, and a higher frequency of eradicable infection foci were significantly associated with C. tertium bacteremia in non-neutropenic patients. There was 15% 30-day mortality. APACHE II score (adjusted odds ratio [aOR], 1.5; 95% confidence interval [CI], 1.1–2.1) and secondary peritonitis (aOR, 25.9; 95% CI, 3.0–224.7) were independent risk factors for 30-day mortality. The prevalence of C. tertium bacteremia is low, and the characteristics of C. tertium bacteremia are significantly different between neutropenic and non-neutropenic patients. Appropriate investigation for gastrointestinal mucosal injury should be performed to improve treatment outcomes in this form of bacteremia.

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Data availability

All data generated or analyzed during this study are included in this published article and its supplementary information files. The datasets are available from the corresponding author on reasonable request.

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Funding

This study was supported by a grant (grant number: 2022IL0036) from the Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea.

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Authors and Affiliations

  1. Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

    Haein Kim, Hyeonji Seo, Sunghee Park, Hyemin Chung, Seongman Bae, Jiwon Jung, Min Jae Kim, Sung-Han Kim, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim & Yong Pil Chong

  2. Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

    Heungsup Sung & Mi-Na Kim

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  1. Haein Kim
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Contributions

Conceptualization: Haein Kim, Yong Pil Chong.

Methodology: Haein Kim, Yong Pil Chong.

Data curation: Haein Kim, Sunghee Park, Hyeonji Seo, Hyemin Chung.

Software, formal analysis: Haein Kim.

Writing–original draft: Haein Kim.

Writing–review and editing: Yong Pil Chong.

Supervision: Heungsup Sung, Mi-Na Kim, Seongman Bae, Jiwon Jung, Min Jae Kim, Sung-Han Kim, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim.

Funding acquisition: Yong Pil Chong.

Corresponding author

Correspondence to Yong Pil Chong.

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Kim, H., Seo, H., Park, S. et al. Clinical significance and outcomes of Clostridium tertium bacteremia: analysis of 62 cases in neutropenic and non-neutropenic patients. Eur J Clin Microbiol Infect Dis 42, 183–191 (2023). https://doi.org/10.1007/s10096-022-04536-y

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