Abstract
The antihyperglycemic effects of the leaves of Acer amoenum and purification and identification of an active compound were investigated. In screening experiments for α-glucosidase inhibitory activity, methanolic extracts of A. amoenum leaves showed potent inhibitory action. This extract showed antihyperglycemic effects in sucrose-loaded mice. Fractionation of the crude extract gave the active compound corilagin [β-1-O-galloyl-3,6-(R)-hexahydroxydiphenoyl-d-glucose] by spectroscopic analysis. This is the first report about the possibility of novel utilization of the Japanese maple tree as a source of compounds for prevention or treatment of diabetes mellitus.
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Brend S, Diethelim T (2009) Atherogenesis and atherothrombosis — focus on diabetes mellitus. Best Pract Res Clin Endocrinol Metabol 23:291–303
Foreyt PJ (2005) Need for lifestyle intervention: How to begin. Am J Cardiol 96:11–14
Kawamori R, Tajima N, Iwamoto Y, Kashiwagi A, Shimamoto K, Kaku K (2009) Voglibose for prevention of type 2 diabetes mellitus: a randomised, double-blind trial in Japanese individuals with impaired glucose tolerance. Lancet 373:1607–1614
Li WL, Zheng HC, Buruku J, De ND (2004) Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus. J Ethnopharmacol 92:1–21
Zareba G, Serradell N, Castaner R, Davis SL, Prous J, Mealy N (2005) Phytotherapies for diabetes. Drugs Future 30:1253–1282
Kim JH, Lee BC, Sim GS, Lee DL, Yun YP, Pyo HB (2005) The isolation and antioxidative effects of vitexin from Acer palmatum. Arch Pharm Res 28:195–202
Aritomi M (1963) Chemical constituents in Aceraceous plants I. Flavonoid constituents in the leaves of Acer palmatum Thumberg (in Japanese). J Pharm Soc Jpn 83:737–740
Ji SB, Saito N, Yokoi M, Shigihara A, Honda T (1992) Galloylcyanidin glycosides from Acer. Phytochemicals 31:655–657
Dahlqvist A (1964) Method for assay of intestinal disaccharidases. Anal Biochem 71:18–25
Wei WX, Pan YJ, Zhang H, Lin CW, Wei TY (2004) Two new compounds from Phyllanthus niruri. Chem Nat Comp 40:460–464
Gao H, Huang YN, Xu PY, Kawabata J (2007) Inhibitory effect of α-glucosidase by fruits of Terminalia chebula Retz. Food Chem 105:628–634
Gutierrez RM, Mitchell S, Solis RV (2008) Psidium guajava: A review of its traditional uses, phytochemistry and pharmacology. J Ethnopharmacol 117:1–27
Sakaguchi K, Kasuga M (2007) Adverse effect of alpha-glucosidase inhibitors (in Japanese). Nippon Rinsho 65:183–187
Sager EP, Hutchinson TC, Croley TR (2005) Foliar phenolics in sugar maple (Acer saccharum) as a potential indicator of tropospheric ozone pollution. Environ Monit Assess 105:419–430
Aritomi M (1964) Chemical constituents in Aceraceous plants. II. Flavonoid constituents in leaves of Acer carpinifolium Siebold et Zuccarini, A. diabolicum Blume, and A. negundo. J Pharm Soc Jpn 84:360–362
Ji SB, Yokoi M, Saito N, Mao LS (1992) Distribution of anthocyanins in Aceraceae leaves. Biochem System Ecol 20:771–781
Miwa I, Okuda J, Horie T, Nakayama M (1986) Inhibition of intestinal α-glucosidase and sugar absorption by flavones. Chem Pharm Bull 34:838–844
Shibano M, Kakutani K, Taniguchi M, Yasuda M, Baba K (2008) Antioxidant constituents in the dayflower (Commelina communis L.) and their α-glucosidase-inhibitory activity. J Nat Med 62: 349–353
Ma X, Wu L, Ito Y, Tian W (2005) Application of preparative highspeed counter-current chromatography for separation of methyl gallate from Acer truncatum Bunge. J Chromatogr A 1076: 212–215
Abou-Zaid MM, Nozzolillo C, Tonon A, Coppens M, Lombardo A (2008) High-performance liquid chromatography characterization and identification of antioxidant polyphenols in maple syrup. Pharm Biol 46:117–125
Kim HJ, Woo ER, Shin CG, Park HK (1998) A new flavonol glucoside gallate ester from Acer okamotoanum and its inhibitory activity against human immunodeficiency virus-1 (HIV-1) integrase. J Nat Prod 61:145–148
Gamberucci A, Konta L, Colucci A, Gunti J, Magyar EJ, Mandl J, Banhegyi G, Benedetti A, Csala M (2006) Green tea flavonoids inhibit glucosidase II. Biol Pharmacol 72:640–646
Toda M, Kawabata J, Kasai T (2004) Inhibitory effects of ellagi- and gallotannins on rat intestinal α-glucosidase complex. Biosci Biotechnol Biochem 65:542–547
Qiang H, Bi S, Kai Y (2006) Interactions of gallotannins with proteins, amino acids, phospholipids and sugars. Food Chem 95: 250–254
Shimada T (2006) Salivary proteins as a defense against dietary tannins. J Chem Ecol 32:1149–1163
Kinoshita S, Inoue Y, Nakama S, Ichiba T, Aniya Y (2007) Antioxidant and hepatoprotective actions of medicinal herb Terminalia catappa L. from Okinawa island and its tannin corilagin. Phytomedicine 14:755–762
Prasad NK, Yang B, Zhao M, Wei X, Jiang Y, Chen F (2009) High pressure extraction of corilagin from longan (Dimocarpus longan Lour.) fruit pericarp. Sep Pur Tech 70:41–45
Okabe S, Suganuma M, Imayoshi Y, Taniguchi S, Yoshida T, Fujiki H (2001) New TNF-α releasing inhibitors, geraniin and corilagin, in leaves of Acer nikoense, Megusurino-ki. Biol Pharm Bull 24:1145–1148
Zao L, Zhang SL, Tao JY, Pang R, ** F, Guo YJ, Dong JH, Ye P, Zhao HY, Zheng GH (2008) Preliminary exploration on antiinflammatory mechanism of corilagin (beta-1-O-galloyl-3,6-(R)-hexahydroxydiphenoyl-d-glucose) in vitro. Int Immunopharmacol 8:1059–1064
Cheng JT, Lin TC, Hsu FL (1995) Antihypertensive effect of corilagin in the rat. Can J Physiol Pharmacol 73:1425–1429
Shiota S, Shimizu M, Sugiyama J, Morita Y, Mizushima T, Tsuchiya T (2004) Mechanisms of action of corilagin and tellimagrandin I that remarkably potentiate the activity of beta-lactams against methicillin-resistant Staphylococcus aureus. Microbiol Immunol 48:67–73
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Honma, A., Koyama, T. & Yazawa, K. Antihyperglycemic effects of Japanese maple Acer amoenum leaf extract and its constituent corilagin. J Wood Sci 56, 507–512 (2010). https://doi.org/10.1007/s10086-010-1130-5
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DOI: https://doi.org/10.1007/s10086-010-1130-5