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The alterations of brain network degree centrality in patients with neovascular glaucoma: a resting-state fMRI study

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Abstract

Purpose

To explore the alterations of whole brain functional network using the degree centrality (DC) analysis in neovascular glaucoma (NVG) and the correlation between DC values and NVG clinical indices.

Materials and methods

Twenty NVG patients and twenty normal controls (NC), closely matched in age, sex, and education, were recruited for this study. All subjects underwent comprehensive ophthalmologic examinations and a resting-state functional magnetic resonance imaging (rs-fMRI) scan. The differences in DC values of brain network between NVG and NC groups were analyzed, and correlation analysis was performed to explore the relationships between DC values and clinical ophthalmological indices in NVG group.

Results

Compared with NC group, significantly decreased DC values were found in the left superior occipital gyrus and left postcentral gyrus, while significantly increased DC values in the right anterior cingulate gyrus and left medial frontal gyrus in NVG group. (All P < 0.05, FDR corrected). In the NVG group, the DC value in left superior occipital gyrus showed significantly positive correlations with retinal nerve fiber layer (RNFL) thickness (R = 0.484, P = 0.031) and mean deviation of visual field (MDVF) (R = 0.678, P = 0.001). Meanwhile, the DC value in the left medial frontal gyrus demonstrated significantly negative correlations with RNFL (R = − 0.544, P = 0.013) and MDVF (R = − 0.481, P = 0.032).

Conclusions

NVG exhibited decreased network degree centrality in visual and sensorimotor brain regions and increased degree centrality in cognitive-emotional processing brain region. Additionally, the DC alterations might be complementary imaging biomarkers to assess disease severity.

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Funding

This work was supported by the National Natural Science Foundation of China (Grant Nos. 81871341 and 82271945).

Author information

Author notes

  1. Yuzhe Wang, Rong Wang, Yin Wang and Linying Guo contributed equally to this work.

Authors and Affiliations

  1. Department of Radiology, Eye & ENT Hospital of Fudan University, Shanghai Medical School, Fudan University, 83 Fenyang Road, Shanghai, 200031, China

    Yuzhe Wang, Yin Wang, Linying Guo, Yang Zhan, Fei Duan, **gfeng Cheng & Zuohua Tang

  2. Department of Radiology, Huashan Hospital of Fudan University, Shanghai Medical School, Fudan University, Shanghai, 200040, China

    Rong Wang

  3. Shanghai Institute of Medical Imaging, Shanghai, 200032, China

    Yang Zhan

Authors
  1. Yuzhe Wang
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Correspondence to Zuohua Tang.

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The protocols of this study were approved by the Local Ethics Committee on Human Research of Eye & ENT Hospital of Fudan University.

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Wang, Y., Wang, R., Wang, Y. et al. The alterations of brain network degree centrality in patients with neovascular glaucoma: a resting-state fMRI study. Neurol Sci 44, 2915–2922 (2023). https://doi.org/10.1007/s10072-023-06664-5

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  • DOI: https://doi.org/10.1007/s10072-023-06664-5

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