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Effect of current conduction for local epileptiform discharges in patients with temporal lobe epilepsy

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Abstract

Objectives

The effects of current conduction were researched to confirm that it can decrease focal epileptogenicity in patients with temporal lobe epilepsy (TLE).

Methods

Data from 13 patients with mesial TLE were collected. After no less than two habitual seizures were captured during stereo-electroencephalogram monitoring, current conduction was measured in the hippocampus to a homemade, zero potential circuit board. The interictal spike, ripple, fast ripple, and ictal epileptogenicity index (EI) changes were analyzed in the hippocampus, amygdala, and anterior and middle temporal neocortex regions.

Results

Significant differences were found in the percentage of patients without spikes in the temporal neocortex between pre- and post-current conduction. Significant decreases in average ripple rates were found in the hippocampus and amygdala after current conduction. The percentage of fast ripple rate decrease in the hippocampus and amygdala was significantly higher than that in the temporal neocortex, and significant decreases were found in the fast ripple rate in the hippocampus from post- to pre-current conduction. Significant decreases were found in the EI values after current conduction in the amygdala and middle temporal lobe compared to the EI values before current conduction.

Conclusion

After current conduction in patients with TLE, the spike rate decreases in the hippocampus, amygdala, and anterior and middle temporal neocortex, the ripple rate decreases in the hippocampus and amygdala, the fast ripple decreases in the hippocampus, and the EI decreases in the amygdala and middle temporal neocortex. Current conduction can reduce epileptogenicity in the hippocampus in mesial TLE.

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Data availability

The authors confirm the data extraction forms are available from the corresponding author upon reasonable request.

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Acknowledgements

The authors would like to show gratitude to the patients and their families for their long-term cooperation.

Funding

This research was supported by the Chinese National Nature and Science Foundation (81771388 and 82071448).

Author information

Authors and Affiliations

  1. Functional Neurosurgery Department, National Children’s Health Center of China, Bei**g Children’s Hospital, Capital Medical University, Bei**g, China

    Shaohui Zhang, Yangshuo Wang, Liu Yuan, Feng Zhai, Tinghong Liu & Shuli Liang

  2. Department of Neurosurgery, First Medical Center, General Hospital of PLA, Bei**g, China

    Shaohui Zhang, Liu Yuan & Shuli Liang

  3. State Key Laboratory of Transducer Technology, Institute of Electronics, Chinese Academy of Sciences, Bei**g, China

    Chunxiu Liu

  4. Key Laboratory of Major Diseases in Children, Ministry of Education, Bei**g, China

    Tinghong Liu & Shuli Liang

Authors
  1. Shaohui Zhang
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  2. Yangshuo Wang
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  3. Chunxiu Liu
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  4. Liu Yuan
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  5. Feng Zhai
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  6. Tinghong Liu
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  7. Shuli Liang
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Contributions

Shuli Liang: supervision, conceptualization; funding acquisition; writing – review and editing.

Shaohui Zhang: investigation; methodology; writing – original draft.

Yangshuo Wang: data curation; formal analysis; investigation; methodology.

Chunxiu Liu: conceptualization; methodology; writing – review and editing.

Liu Yuan: investigation; methodology.

Feng Zhai: writing – original draft and project administration.

Tinghong Liu: data curation; investigation.

Corresponding authors

Correspondence to Chunxiu Liu or Shuli Liang.

Ethics declarations

Ethical approval and informed consent

This study was approved by the Ethics Committee of the Fourth Medical Center, PLA General Hospital (No. 2019KY003HS001), and written informed consent was obtained from each patient. This study was conducted in accordance with the Declaration of Helsinki.

Ethical publication

We declare that we have read the statements provided by the journal regarding ethical publication, and we affirm that this report is consistent with these guidelines.

Conflict of interest

The authors declare no competing interests.

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Shaohui Zhang and Yangshuo Wang are co-first authors.

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Cite this article

Zhang, S., Wang, Y., Liu, C. et al. Effect of current conduction for local epileptiform discharges in patients with temporal lobe epilepsy. Neurol Sci 43, 6471–6478 (2022). https://doi.org/10.1007/s10072-022-06337-9

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  • DOI: https://doi.org/10.1007/s10072-022-06337-9

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