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Effects of tomato ketchup and tomato paste extract on hepatic lipid accumulation and adipogenesis

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Abstract

Tomatoes include high levels of lycopene, which is a potent antioxidative, hypolipidemic, and antidiabetic phytochemical. The intake of lycopene is associated with a reduced risk of insulin resistance and metabolic syndrome. The aim of this study was to investigate whether tomato ketchup and tomato paste, major dietary sources for tomato and lycopene, could regulate hepatic lipid metabolism and adipogenesis. To investigate the regulatory effects of tomato ketchup and tomato paste, we prepared a tomato ketchup extract (TKE) and a tomato paste extract (TPE) in 80% (v/v) ethyl acetate for the experiment. TKE and TPE reduced lipid accumulation and key markers for gluconeogenesis and induced a higher rate of fatty acid oxidation in HepG2 hepatocytes. In 3T3-L1 adipocytes, TKE and TPE increased adipogenesis and intracellular triglyceride accumulation, and stimulated glucose uptake. Peroxisome proliferator-activated receptor alpha and gamma expression levels were increased by TKE and TPE treatment. A single oral dose of tomato ketchup and tomato paste (9.28 g/kg) significantly improved glucose and insulin tolerance in mice. These findings suggest that lycopene-containing tomato ketchup and tomato paste may have beneficial regulatory effects in terms of energy metabolism in hepatocytes and adipocytes, and thus may improve blood glucose metabolism.

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Funding

This work received support from Ottogi Corporation (Intramural project # Q1917681).

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Authors and Affiliations

  1. Department of Biotechnology, Graduate School of Life Sciences & Biotechnology, College of Life Sciences & Biotechnology, Korea University, Seoul, 02841, Republic of Korea

    Ji Hyun Jeong, Ha Lim Lee, Hyun Ji Park, Ye Eun Yoon, Jaeeun Shin, Mi-Young Jeong & Sung-Joon Lee

  2. Department of Food & Nutrition, College of Life Sciences, Gangneung-Wonju National University, Gangneung, South Korea

    Sung Hoon Park

  3. R&D Center, Ottogi Corporation, Anyang-Si, 14060, Republic of Korea

    Da-hye Kim, Seung-Woo Han, Choon-Gil Kang & Ki-Ju Hong

  4. Department of Food Bioscience & Technology, College of Life Sciences & Biotechnology, Korea University, Seoul, South Korea

    Sung-Joon Lee

  5. Interdisciplinary Program in Precision Public Health, BK21 Four Institute of Precision Public Health, Korea University, Seoul, South Korea

    Sung-Joon Lee

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  1. Ji Hyun Jeong
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Jeong, J.H., Lee, H.L., Park, H.J. et al. Effects of tomato ketchup and tomato paste extract on hepatic lipid accumulation and adipogenesis. Food Sci Biotechnol 32, 1111–1122 (2023). https://doi.org/10.1007/s10068-023-01244-x

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