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Efficacy of simvastatin in bone regeneration after surgical removal of mandibular third molars

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Abstract

Purpose

The aim of this study was to assess the efficacy of simvastatin in bone regeneration in extraction sockets of mandibular third molars using cone beam computed tomography (CBCT) at 6th post-operative month.

Methods

This is a prospective randomized split-mouth study involving 15 patients who underwent surgical extraction of bilaterally impacted mandibular third molars with similar morphology on the same day. The efficacy of drug was analyzed by implanting 10 mg of simvastatin into the socket (study site) and observations were made over 6 months to compare the healing with the control site.

Results

The study results demonstrated a statistically significant difference in bone regeneration: mean gray value of 429.133 in study site compared with mean gray value of 310.153 in the control site.

Conclusion

These values demonstrate significant change in bone regeneration in simvastatin site as compared to that of control site.

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Authors and Affiliations

  1. Meenakshi Ammal Dental College and Hospital, Chennai, Tamil Nadu, India

    Megarasu Deepanjali, Tangutur Srinivasa Prasad & Pedamally Manodh

Authors
  1. Megarasu Deepanjali
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  2. Tangutur Srinivasa Prasad
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  3. Pedamally Manodh
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Corresponding author

Correspondence to Megarasu Deepanjali.

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Ethics approval

Ethics approval is obtained by the institutional review board of Meenakshi Ammal Dental College and Hospital, MAHER University, Chennai. Reference number—MADC/IRB/2017/215.

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Informed consent was obtained from all individual participants included in the study.

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No individual person’s data was included in this manuscript.

Competing interests

The authors declare no competing interests.

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Deepanjali, M., Prasad, T.S. & Manodh, P. Efficacy of simvastatin in bone regeneration after surgical removal of mandibular third molars. Oral Maxillofac Surg 27, 427–432 (2023). https://doi.org/10.1007/s10006-022-01081-y

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  • DOI: https://doi.org/10.1007/s10006-022-01081-y

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