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Esomeprazole use is independently associated with significant reduction of BMD: 1-year prospective comparative safety study of four proton pump inhibitors

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Abstract

Because of the efficacy of proton pump inhibitors (PPIs), their the use is increasing dramatically. The risk of adverse effects of short-term PPI therapy is low, but there are important safety concerns for potential adverse effects of prolonged PPI therapy. Findings from studies assessing the association between PPI use and bone mineral density (BMD) and/or fracture risk are contradictory. The aim of this study was to prospectively assess potential association of PPI treatment with the 12-month change in BMD of the lumbar spine, femur neck, and total hip. The study was performed in 200 PPI users and 50 PPI nonusers. Lumbar spine (L1–L4), femur neck, and total hip BMD were measured by dual-energy X-ray absorptiometry at the baseline and at 12 months. A total of 209 subjects completed the entire 12 months of the study and were included in the final analysis. A Wilcoxon signed-rank test showed that at 12 months PPI use was associated with statistically significant reductions in femur neck and total hip T scores (Z = −2.764, p = 0.005 and Z = −3.281, p = 0.001, respectively). A multiple linear regression analysis showed that only esomeprazole added significantly to the prediction of total lumbar spine and femur neck T scores (p = 0.048 and p = 0.037, respectively). Compared with the baseline, 12 months of PPI treatment resulted in lower femur neck and total hip BMD T scores. Among the four PPIs studied, esomeprazole was independently associated with significant reduction of BMD, whereas omeprazole had no effects on BMD. Considering the widespread use of PPIs, BMD screening should be considered in the case of prolonged PPI use.

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Acknowledgment

This study was partially supported by a grant from the Ministry of Education, Science and Technology of the Republic of Kosovo (grant no. 2-4447).

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Authors and Affiliations

  1. Department of Pharmacology, Faculty of Medicine, University of Prishtina, Prishtina, Republic of Kosovo

    Elton Bahtiri, Hilmi Islami, Rexhep Hoxha & Hasime Qorraj-Bytyqi

  2. Department of Rheumatology, Faculty of Medicine, University of Prishtina, Prishtina, Kosovo

    Sylejman Rexhepi

  3. School of Pharmacy, Faculty of Health Sciences, Curtin University, Bentley, Australia

    Kreshnik Hoti

  4. Department of Biochemistry, Faculty of Medicine, University of Prishtina, Prishtina, Kosovo

    Kujtim Thaçi

  5. Department of Physiology, Faculty of Medicine, University of Prishtina, Prishtina, Kosovo

    Shpetim Thaçi

  6. Department of Pharmacology, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey

    Çağla Karakulak

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  1. Elton Bahtiri
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  2. Hilmi Islami
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Correspondence to Rexhep Hoxha.

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Bahtiri, E., Islami, H., Hoxha, R. et al. Esomeprazole use is independently associated with significant reduction of BMD: 1-year prospective comparative safety study of four proton pump inhibitors. J Bone Miner Metab 34, 571–579 (2016). https://doi.org/10.1007/s00774-015-0699-6

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  • DOI: https://doi.org/10.1007/s00774-015-0699-6

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