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Sarkopenie − Diagnostik und mögliche Therapien

Sarcopenia—diagnostics and possible treatment

  • Integrative Onkologie
  • Published:
Der Onkologe Aims and scope

Zusammenfassung

Sarkopenie bedeutet Verlust von Muskelmasse und -funktion. Die derzeitige Forschung zum Begriff der Sarkopenie fokussiert sich größtenteils auf geriatrische Patienten und zeigt deutlich, dass Sarkopenie die Fähigkeit der Alltagsbewältigung erheblich einschränkt, zu Bewegungsstörungen führen und die Lebensqualität mindern kann. Bei Tumorpatienten geht das Vorhandensein von Sarkopenie mit einer erhöhten Morbidität und Mortalität einher. Auch wenn sich das Verständnis für das Krankheitsbild und die Behandlung von Sarkopenie bereits gebessert hat, konnten Forschungsergebnisse bisher noch nicht in den klinischen Alltag integriert werden. Deshalb fasst dieser Artikel die aktualisierte Definition von Sarkopenie zusammen und bietet einen Einblick in die Therapiemethoden. Des Weiteren wird die Bedeutung Evidenz unterstützender Ernährungsinterventionen und Bewegung für die Therapie von Sarkopenie erläutert.

Abstract

Sarcopenia describes the loss of skeletal muscle mass and function. The current research on the topic of sarcopenia focuses mostly on geriatric patients and has revealed that sarcopenia can substantially impair the ability to perform activities of daily living, can lead to mobility disorders and also contributes to a lower quality of life. In cancer patients sarcopenia has also been found to be associated with increased morbidity and mortality. Even though the understanding of the concept and treatment of sarcopenia has already been improved, research findings have not yet been translated into clinical practice. Therefore, this article summarizes the updated definition of sarcopenia and provides insights into treatment methods. Furthermore, evidence supporting nutritional interventions and physical activity for treatment of sarcopenia are presented.

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Abb. 1

Notes

  1. Die Terminologie Muskelproteinsynthese und myofibrilläre Proteinsynthese werden austauschbar angewendet. Sie werden aber mit den gleichen Formeln berechnet.

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Authors and Affiliations

  1. Krebszentrum – CCC MünchenLMU – Comprehensive Cancer Center, am Klinikum der Universität München, Campus Großhadern, LMU München, Marchioninistr. 15, 81377, München, Deutschland

    Lian Liu, Nicole Tonya Erickson M.Sc., RD,  Laura-Sophie Marquort &  Julian W. Holch

  2. AG Prävention und integrativen Onkologie (AG PRIO), Deutschen Krebsgesellschaft, Ringbahnstr. 16–20, 12099, Berlin, Deutschland

    Nicole Tonya Erickson M.Sc., RD,  Thorsten Schmidt &  Christine Reudelstertz

  3. Krebszentrum Nord, CCC, Campus Kiel, Universitätsklinikum Schleswig-Holstein, Arnold-Heller-Straße 3, Haus 14, 24105, Kiel, Deutschland

    Thorsten Schmidt

  4. Medizinische Klinik und Poliklinik III, Klinikum der Universität München, Marchioninistraße 15, 81377, München, Deutschland

    Julian W. Holch

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  1. Lian Liu
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Correspondence to Nicole Tonya Erickson M.Sc., RD.

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N.T. Erickson gibt an, dass keine finanziellen oder persönlichen Beziehungen zu Dritten bestehen, deren Interessen von diesem Manuskript positiv oder negativ betroffen sein könnten. Sie hat Honorare von u. a. B.Braun, Fresenius, CSL Behring, Hipp GmbH, GHD Gmbh erhalten. C. Reudelstertz arbeitet als freiberufliche Dipl. Oecotrophologin im Bereich medizinisch wissenschaftliche Beratungsleistungen u. a. für Fresenius Kabi und BBraun. J.W. Holch hat medizinisch wissenschaftliche Beratungsleistungen für Roche erhalten und Reisekostenerstattung von Novartis. L. Liu, L.-S. Marquort und T. Schmidt geben an, dass kein Interessenkonflikt besteht.

Für diesen Beitrag wurden von den Autoren keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.

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In Zusammenarbeit mit der AG Prävention und integrativen Onkologie (AG PRIO), Deutschen Krebsgesellschaft, Berlin

Lian Liu, Nicole Tonya Erickson: geteilte Erstautoren

Julian W. Holch: Letztautor

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Liu, L., Erickson, N.T., Marquort, LS. et al. Sarkopenie − Diagnostik und mögliche Therapien. Onkologe 25, 819–826 (2019). https://doi.org/10.1007/s00761-019-0614-1

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  • DOI: https://doi.org/10.1007/s00761-019-0614-1

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