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Acylation of terminal alkynes with N-acylbenzotriazole: synthesis of conjugated ynones in ionic liquids

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Abstract

1-Butyl-3-methylimidazolium tetra-fluoroborate ([BMIM][BF4]) has been used as an ionic liquid for the synthesis of conjugated ynones in good yields from alkyl/aryl N-acylbenzotriazoles and terminal alkynes in catalytic amounts of zinc chloride. Mild reaction conditions, short reaction time, and excellent functional group tolerance with broad substrate scope are the advantages of this protocol. The [BMIM][BF4] can be recovered and reused without significant loss in efficiency.

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  1. Department of Chemistry and Chemical Technology, Tafila Technical University, Tafila, Jordan

    Khalid Widyan

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  1. Khalid Widyan
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Correspondence to Khalid Widyan.

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Dedicated to the late Prof. Alan R. Katritzky for his excellent contributions to benzotriazole chemistry.

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Widyan, K. Acylation of terminal alkynes with N-acylbenzotriazole: synthesis of conjugated ynones in ionic liquids. Monatsh Chem 154, 645–649 (2023). https://doi.org/10.1007/s00706-023-03066-3

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