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Hefer valley virus: a novel ephemerovirus detected in the blood of a cow with severe clinical signs in Israel in 2022

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Abstract

A novel ephemerovirus was identified in a Holstein-Friesian cow in the Hefer Valley, Israel, that showed severe and fatal clinical signs resembling an arboviral infection. A sample taken during the acute phase tested negative for important endemic arboviral infectious cattle diseases. However, sequencing from blood revealed the full genome sequence of Hefer Valley virus, which is likely to represent a new species within the genus Ephemerovirus, family Rhabdoviridae. Archived samples from cattle with comparable clinical signs collected in Israel in 2021 and 2022 tested negative for the novel virus, and therefore, the actual distribution of the virus is unknown. As this is a recently identified new viral infection, the viral vector and the prevalence of the virus in the cattle population are still unknown but will be the subject of future investigations.

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Data availability

The annotated genome sequences generated during and/or analysed in the current study are available in the DDBJ/EMBL/GenBank databases under the accession number OQ679991.

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Funding

This research was funded by the Israeli Dairy Board, grant number 848 − 0351, received by NG and EK.

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Authors and Affiliations

  1. Department of Virology, Kimron Veterinary Institute, Bet Dagan, Israel

    Natalia Golender

  2. Koret School of Veterinary Medicine, The Robert H. Smith Faculty of Agriculture, Food & Environment, The Hebrew University of Jerusalem, Rehovot, Israel

    Natalia Golender & Eyal Klement

  3. Hachaklait veterinary services, Caesarea, Israel

    Lior Ofer

  4. Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Greifswald, Germany

    Bernd Hoffmann, Kerstin Wernike, Martin Beer & Florian Pfaff

Authors
  1. Natalia Golender
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  2. Eyal Klement
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  3. Lior Ofer
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  4. Bernd Hoffmann
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  5. Kerstin Wernike
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  6. Martin Beer
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  7. Florian Pfaff
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Contributions

Methodology: N.G., F.P. Material and data collection: L.O. Data curation: B.H., K.W., M.B., E.K., F.P. Writing – original draft preparation: N.G. Writing –review and editing: B.H., K.W., M.B., E.K, F.P. Visualization: F.P. All authors have read and agreed to the published version of the manuscript.

Corresponding author

Correspondence to Natalia Golender.

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Conflict of interest

The authors have no relevant financial or non-financial interests to disclose.

Ethical approval

This article does not contain any studies with human participants performed by any of the authors. The sample from the HVV-infected cow was collected by the responsible farm veterinarian during health monitoring, and the stored samples represent superfluous material from routine diagnostic submissions collected by the responsible veterinarians in the context of the health monitoring on the respective farms. No permission was needed to collect these specimens.

Additional information

Communicated by William G Dundon

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Golender, N., Klement, E., Ofer, L. et al. Hefer valley virus: a novel ephemerovirus detected in the blood of a cow with severe clinical signs in Israel in 2022. Arch Virol 168, 234 (2023). https://doi.org/10.1007/s00705-023-05850-2

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  • DOI: https://doi.org/10.1007/s00705-023-05850-2

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