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Concurrent cerebral infarction and intracranial tuberculoma induced by the carotid plaque complicated with miliary tuberculosis

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Abstract

Cerebrovascular complications of central nervous system tuberculosis (TB) are predictors of poor prognosis and adverse outcomes. These complications are mainly intracranial arterial involvement, with occasional venous involvement. Here, we present a 67-year-old woman with concurrent cerebral infarction and intracranial tuberculoma induced by the carotid plaque complicated by miliary tuberculosis. Mycobacterium tuberculosis was observed on the luminal side of the carotid plaques in pathological specimens. Treatment with anti-TB drugs alone would likely not cure the patient, as M. tuberculosis would continue to disseminate. Endarterectomy could directly remove the embolic source, and a complete cure was achieved.

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The anonymized individual patient data used and/or analyzed during the current study are available from the corresponding author upon reasonable request.

References

  1. Chatterjee D, Radotra BD, Vasishta RK, Sharma K (2015) Vascular complications of tuberculous meningitis: an autopsy study. Neurol India 63:926–932

    Article  PubMed  Google Scholar 

  2. Dalal PM (1979) Observations on the involvement of cerebral vessels in tuberculous meningitis in adults. Adv Neurol 25:149–159

    CAS  PubMed  Google Scholar 

  3. Dastur DK, Lalitha VS, Udani P, Parekh U (1970) The brain and meninges in tuberculous meningitis: gross pathology in 100 cases and pathogenesis. Neurol India 18:86–94

    CAS  PubMed  Google Scholar 

  4. Deshpande DH, Bharucha EP, Mondkar VP (1969) Tuberculous meningitis in adults (a clinico-pathological study of 18 cases). Neurol India 17:28–34

    CAS  PubMed  Google Scholar 

  5. Garcia-Monco JC (1999) Central nervous system tuberculosis. Neurol Clin 17:737–759

    Article  CAS  PubMed  Google Scholar 

  6. Kalita J, Misra UK, Nair PP (2009) Predictors of stroke and its significance in the outcome of tuberculous meningitis. J Stroke Cerebrovasc Dis 18:251–258

    Article  PubMed  Google Scholar 

  7. Kalita J, Singh RK, Misra UK, Kumar S (2018) Evaluation of cerebral arterial and venous system in tuberculous meningitis. J Neuroradiol 45:130–135

    Article  PubMed  Google Scholar 

  8. Marais S, Thwaites G, Schoeman JF, Török ME, Misra UK, Prasad K, Donald PR, Wilkinson RJ, Marais BJ (2010) Tuberculous meningitis: a uniform case definition for use in clinical research. Lancet Infect Dis 10:803–812

    Article  PubMed  Google Scholar 

  9. Misra UK, Kalita J, Maurya PK (2011) Stroke in tuberculous meningitis. J Neurol Sci 303:22–30

    Article  PubMed  Google Scholar 

  10. Poltera AA, Templeton AC (1973) Intracranial tuberculosis in Uganda: a post-mortem survey. Afr J Med Sci 4:343–349

    CAS  PubMed  Google Scholar 

  11. Rohilla R, Shafiq N, Malhotra S (2021) Efficacy and safety of aspirin as an adjunctive therapy in tubercular meningitis: a systematic review and meta-analysis. E Clin Med 34:100819

    CAS  Google Scholar 

  12. Sheu JJ, Hsu CY, Yuan RY, Yang CC (2012) Clinical characteristics and treatment delay of cerebral infarction in tuberculous meningitis. Intern Med J 42:294–300

    Article  PubMed  Google Scholar 

  13. Shukla R, Abbas A, Kumar P, Gupta RK, Jha S, Prasad KN (2008) Evaluation of cerebral infarction in tuberculous meningitis by diffusion weighted imaging. J Infect 57:298–306

    Article  PubMed  Google Scholar 

  14. Singh B, Garg RK, Singh MK, Verma R, Malhotra HS, Jain A, Singh R, Kohli N, Phadke RV, Shukla R, Parihar (2012) Computed tomography angiography in patients with tuberculous meningitis. J Infect 64:565–572

  15. Thomas MD, Chopra JS, Walia BNS (1977) Tuberculous meningitis (TBM): a clinical study of 232 cases. J Assoc Physicians India 25:633–639

    CAS  PubMed  Google Scholar 

  16. Thwaites GE, Macmullen-Price J, Tran TH, Pham PM, Nguyen TD, Simmons CP, White NJ, Tran TH, Summers D, Farrar JJ (2007) Serial MRI to determine the effect of dexamethasone on the cerebral pathology of tuberculous meningitis: an observational study. Lancet Neurol 6:230–236

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Thwaites GE, van Toorn R, Schoeman J (2013) Tuberculous meningitis: more questions, still too few answers. Lancet Neurol 12:999–1010

    Article  CAS  PubMed  Google Scholar 

  18. Wasay M, Farooq S, Khowaja ZA, Bawa ZA, Ali SM, Awan S, Beg MA, Mehndiratta MM (2014) Cerebral infarction and tuberculoma in central nervous system tuberculosis: frequency and prognostic implications. J Neurol Neurosurg Psychiatry 85:1260–1264

    Article  PubMed  Google Scholar 

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Acknowledgements

We would like to thank Editage (www.editage.com) for the English language editing.

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Correspondence to Shinsuke Muraoka.

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Ethics approval

This study was approved by the local ethics committee on April 19th, 2022 (approval number: 1054). All procedures performed were in accordance with the ethical standards of the Declaration of Helsinki. All experiments were performed by CARE guidelines.

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The written informed consent was obtained from the patient.

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The authors declare no competing interests.

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Muraoka, S., Oguri, T., Kimura, R. et al. Concurrent cerebral infarction and intracranial tuberculoma induced by the carotid plaque complicated with miliary tuberculosis. Acta Neurochir 165, 647–650 (2023). https://doi.org/10.1007/s00701-023-05489-7

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  • DOI: https://doi.org/10.1007/s00701-023-05489-7

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