Abstract
Rapid technological advancements have created opportunities for new solutions in various industries, including healthcare. One exciting new direction in this field of innovation is the combination of skin-based technologies and augmented reality (AR). These dermatological devices allow for the continuous and non-invasive measurement of vital signs and biomarkers, enabling the real-time diagnosis of anomalies, which have applications in telemedicine, oncology, dermatology, and early diagnostics. Despite its many potential benefits, there is a substantial information vacuum regarding using flexible photonics in conjunction with augmented reality for medical purposes. This review explores the current state of dermal augmented reality and flexible optics in skin-conforming sensing platforms by examining the obstacles faced thus far, including technical hurdles, demanding clinical validation standards, and problems with user acceptance. Our main areas of interest are skills, chiroptical properties, and health platform applications, such as optogenetic pixels, spectroscopic imagers, and optical biosensors. My skin-enhanced spherical dichroism and powerful spherically polarized light enable thorough physical inspection with these augmented reality devices: diabetic tracking, skin cancer diagnosis, and cardiovascular illness: preventative medicine, namely blood pressure screening. We demonstrate how to accomplish early prevention using case studies and emergency detection. Finally, it addresses real-world obstacles that hinder fully realizing these materials’ extraordinary potential in advancing proactive and preventative personalized medicine, including technical constraints, clinical validation gaps, and barriers to widespread adoption.
Graphical abstract
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References
Iwendi C (2023) Innovative augmented and virtual reality applications for disease diagnosis based on integrated genetic algorithms. Int J Cogn Comput Eng 4:266–276. https://doi.org/10.1016/j.ijcce.2023.07.004
Parekh P, Patel S, Patel N, Shah M (2020) Systematic review and meta-analysis of augmented reality in medicine, retail, and games. Vis Comput Ind Biomed Art 3. https://doi.org/10.1186/s42492-020-00057-7
Ahmed Taha B, Al-Jubouri Q, Chahal S et al (2023) State-of-the-art telemodule-enabled intelligent optical nano-biosensors for proficient SARS-CoV-2 monitoring. Microchem J:109774. https://doi.org/10.1016/j.microc.2023.109774
Taha BA, Al Mashhadany Y, Al-Jubouri Q et al (2023) Next-generation nanophotonic-enabled biosensors for intelligent diagnosis of SARS-CoV-2 variants. Sci Total Environ 880:163333. https://doi.org/10.1016/j.scitotenv.2023.163333
Mehta V (2018) Devraj, Chugh H, Banerjee P (2018) Applications of augmented reality in emerging health diagnostics: a survey. Int Conf Autom Comput Eng ICACE 2018:45–51. https://doi.org/10.1109/ICACE.2018.8687114
Hong C, Wang L (2023) Virtual reality technology in nursing professional skills training: bibliometric analysis. JMIR Serious Games 11. https://doi.org/10.2196/44766
Taha BA, Al-Jubouri Q, Al Mashhadany Y et al (2023) Density estimation of SARS-CoV2 spike proteins using super pixels segmentation technique. Appl Soft Comput 138:110210. https://doi.org/10.1016/j.asoc.2023.110210
Piszczek M, MacIejewski M, Pomianek M (2018) Photonic input-output devices used in virtual and augmented reality technologies. URSI 2018 - Balt URSI Symp 145–146. https://doi.org/10.23919/URSI.2018.8406754
Manea HK, Molood YN, Al-Jubouri Q et al (2023) A comparative study of plastic and glass optical fibers for reliable home networking. ECS J Solid State Sci Technol 12:057003. https://doi.org/10.1149/2162-8777/acd1ac
Taha BA (2021) Perspectives of photonics technology to diagnosis COVID–19 viruses: a short review. J Appl Sci Nanotechnol 1:1–6. https://doi.org/10.53293/jasn.2021.11016
Taha BA, Al Mashhadany Y, Al-Jubouri Q et al (2023) Uncovering the morphological differences between SARS-CoV-2 and SARS-CoV based on transmission electron microscopy images. Microbes Infect 25:105187. https://doi.org/10.1016/j.micinf.2023.105187
Xu C, Solomon SA, Gao W (2023) Artificial intelligence-powered electronic skin. Nat Mach Intell 5:1344–1355. https://doi.org/10.1038/s42256-023-00760-z
Min J, Demchyshyn S, Sempionatto JR et al (2023) An autonomous wearable biosensor powered by a perovskite solar cell. Nat Electron 6:630–641. https://doi.org/10.1038/s41928-023-00996-y
Sadri B, Gao W (2023) Fibrous wearable and implantable bioelectronics. Appl Phys Rev 10. https://doi.org/10.1063/5.0152744
Zhou W, Zhang C, Ren A et al (2023) Responsive liquid-crystal microlaser arrays with tactile perception. Adv Opt Mater 11:2202879. https://doi.org/10.1002/adom.202202879
Zhu L, Wang Y, Mei D et al (2022) Large‐area hand‐covering elastomeric electronic skin sensor with distributed multifunctional sensing capability. Adv Intell Syst 4. https://doi.org/10.1002/aisy.202100118
Fan L, He Z, Peng X et al (2021) Injectable, intrinsically antibacterial conductive hydrogels with self-healing and ph stimulus responsiveness for epidermal sensors and wound healing. ACS Appl Mater Interfaces 13:53541–53552. https://doi.org/10.1021/acsami.1c14216
Masood T, Egger J (2021) Augmented reality: focusing on photonics in Industry 4.0. IEEE J Sel Top Quantum Electron 27. https://doi.org/10.1109/JSTQE.2021.3093721
Cañón Bermúdez GS, Karnaushenko DD, Karnaushenko D et al (2018) Magnetosensitive e-skins with directional perception for augmented reality. Sci Adv 4:1–10. https://doi.org/10.1126/sciadv.aao2623
Haider AJ, Sultan FI, Haider MJ et al (2023) Characterization of laser dye concentrations in ZnO nanostructures for optimization of random laser emission performance. Int J Mod Phys B 2450111:1–24. https://doi.org/10.1142/S021797922450111X
Taha BA, Al MY, Al-Jumaily AHJ et al (2022) SARS-CoV-2 morphometry analysis and prediction of real virus levels based on full recurrent neural network using TEM images. Viruses 14:2386. https://doi.org/10.3390/v14112386
Taha BA, Mehde MS, Haider AJ, Arsad N (2023) Mathematical model of the DBR laser for thermal tuning: taxonomy and performance effectiveness with PbSe materials. J Opt 52:1415–1425. https://doi.org/10.1007/s12596-022-00978-x
& SM, Sumant O, PORTLAND O (2020) Ar in healthcare market. Allied Mark Res Publ a Rep 5285:1–8
Chengoden R, Victor N, Huynh-The T et al (2023) Metaverse for healthcare: a survey on potential applications, challenges and future directions. IEEE Access 11:12765–12795
Kim K, Yang H, Lee J, Lee WG (2023) Metaverse wearables for immersive digital healthcare: a review. Adv Sci 10:2303234. https://doi.org/10.1002/advs.202303234
Ashely-Welbeck A, Vlachopoulos D (2020) Teachers’ perceptions on using Augmented Reality for language learning in Primary Years Programme (PYP) education. Int J Emerg Technol Learn 15:116–135. https://doi.org/10.3991/ijet.v15i12.13499
Xu J, Pan J, Cui T et al (2023) Recent progress of tactile and force sensors for human–machine interaction. Sensors 23:1–27. https://doi.org/10.3390/s23041868
Kazemzadeh K, Akhlaghdoust M, Zali A (2023) Advances in artificial intelligence, robotics, augmented and virtual reality in neurosurgery. Front Surg:10
Douglas DB, Wilke CA, Gibson JD et al (2017) Augmented reality: advances in diagnostic imaging. Multimodal Technol Interact 1:29
Rus G, Andras I, Vaida C et al (2023) Artificial intelligence-based hazard detection in robotic-assisted single-incision oncologic surgery. Cancers (Basel) 15:3387
Favolise M (2021) The effectiveness of augmented and virtual reality in the education of physical therapy students. Arch Phys Med Rehabil 102:e84
Khokale R, Mathew GS, Ahmed S et al (2023) Virtual and augmented reality in post-stroke rehabilitation: a narrative review. Cureus. https://doi.org/10.7759/cureus.37559
Ahmad I, Asghar Z, Kumar T et al (2022) Emerging technologies for next generation remote health care and assisted living. IEEE Access 10:56094–56132. https://doi.org/10.1109/ACCESS.2022.3177278
Worlikar H, Coleman S, Kelly J et al (2023) Mixed reality platforms in telehealth delivery: sco** review. JMIR Biomed Eng 8:e42709. https://doi.org/10.2196/42709
Zhavoronkov A, Vanhaelen Q, Oprea TI (2020) Will artificial intelligence for drug discovery impact clinical pharmacology? Clin Pharmacol Ther 107:780–785. https://doi.org/10.1002/cpt.1795
Lush V, Buckingham C, Edwards S, Bernardet U (2020) Towards accessible mental healthcare through augmented reality and self-assessment tools. Int J Online Biomed Eng 16:33. https://doi.org/10.3991/ijoe.v16i04.12095
Luo C (2024) Unlocking medical potentials: an in-depth investigation of augmented reality technology in medicine. Commun Humanit Res 27:126–130. https://doi.org/10.54254/2753-7064/27/20232151
Lim-Saco F (2019) Philosophical and contextual issues in nursing theory development concerning technological competency as caring in nursing. J Med Investig 66:8–11. https://doi.org/10.2152/jmi.66.8
Shine, MBA, CBE T, Thomason, PhD, Msc. J, Khan, PhD I et al (2023) Blockchain in healthcare: 2023 predictions from around the globe. Blockchain Healthc Today 6. https://doi.org/10.30953/bhty.v6.245
Noghabaei M, Heydarian A, Balali V, Han K (2020) Trend analysis on adoption of virtual and augmented reality in the architecture, engineering, and construction industry. Data 5:26. https://doi.org/10.3390/data5010026
Farooq MS, Zahid Z, Omer U et al (2022) Applications of augmented reality in neurology: architectural model and guidelines. IEEE Access 10:102804–102830. https://doi.org/10.1109/ACCESS.2022.3206600
Cirillo A, Cirillo P, De Maria G et al (2014) An artificial skin based on optoelectronic technology. Sensors Actuators A Phys 212:110–122. https://doi.org/10.1016/j.sna.2014.03.030
Taha BA, Addie AJ, Haider AJ et al (2024) Exploring trends and opportunities in quantum-enhanced advanced photonic illumination technologies. Adv Quantum Technol 2300414:1–19. https://doi.org/10.1002/qute.202300414
Li H, **e R, **aoqing WEI, Wang J (2022) Flexible photonic skin, 11419548. https://patents.google.com/patent/US20200359963A1/en?oq=Patent+Publication+Number:+20200359963
Zhang C, Dong H, Zhang C et al (2021) Photonic skins based on flexible organic microlaser arrays. Sci Adv 7:1–9. https://doi.org/10.1126/sciadv.abh3530
Peng X, Dong K, Ye C et al (2020) A breathable, biodegradable, antibacterial, and self-powered electronic skin based on all-nanofiber triboelectric nanogenerators. Sci Adv 6. https://doi.org/10.1126/sciadv.aba9624
Gao L, Zhang Y, Malyarchuk V et al (2014) Epidermal photonic devices for quantitative imaging of temperature and thermal transport characteristics of the skin. Nat Commun 5:1–10. https://doi.org/10.1038/ncomms5938
Liu X, Ren G, Xu X et al (2023) “Dial up” photonic integrated circuit filter. J Light Technol 41:1775–1783. https://doi.org/10.1109/JLT.2022.3226685
Shi Y, Wan C, Dai C et al (2022) Augmented reality enabled by on-chip meta-holography multiplexing. Laser Photon Rev 16:2100638. https://doi.org/10.1002/lpor.202100638
Nishant A, Kim K-J, Showghi SA et al (2022) High refractive index chalcogenide hybrid inorganic/organic polymers for integrated photonics. Adv Opt Mater 10:2200176. https://doi.org/10.1002/adom.202200176
Millard K, Rainouard F (2023, March) Convergence of mathematical and physical optical designs for the development of random photonic integrated circuits for an unconventional AR display concept. In: Optical architectures for displays and sensing in augmented, virtual, and mixed reality (AR, VR, MR) IV, vol 12449. SPIE, pp 152–161
Chen M, Lu L, Yu H et al (2021) Integration of colloidal quantum dots with photonic structures for optoelectronic and optical devices. Adv Sci 8:1–22. https://doi.org/10.1002/advs.202101560
Liba O, Sorelle ED, Sen D, De La Zerda A (2016) Contrast-enhanced optical coherence tomography with picomolar sensitivity for functional in vivo imaging. Sci Rep 6:1–12. https://doi.org/10.1038/srep23337
Mat Yeh RM, Taha BA, Bachok NN et al (2024) Advancements in detecting porcine-derived proteins and DNA for enhancing food integrity: taxonomy, challenges, and future directions. Food Control 161:110399. https://doi.org/10.1016/j.foodcont.2024.110399
Taha BA, Mokhtar MHH, Apsari R et al (2023) Nanotools for screening neurodegenerative diseases. In: Gautam A, Chaudhary V (eds) Theranostic applications of nanotechnology in neurological disorders. Springer Nature Singapore, Singapore, pp 251–266
Wan B, Ganier C, Du-Harpur X et al (2021) Applications and future directions for optical coherence tomography in dermatology*. Br J Dermatol 184:1014–1022. https://doi.org/10.1111/bjd.19553
Ji X, Mojahed D, Okawachi Y et al (2021) Millimeter-scale chip–based supercontinuum generation for optical coherence tomography. Sci Adv 7:eabg8869. https://doi.org/10.1126/sciadv.abg8869
Shen K, Lu H, Wang MR (2016) Improving lateral resolution of optical coherence tomography for imaging of skins. Three-dimensional multidimens microsc image acquis process XXIII, vol 9713. pp 97130N. https://doi.org/10.1117/12.2213143
Adabi S, Turani Z, Fatemizadeh E et al (2017) Optical coherence tomography technology and quality improvement methods for optical coherence tomography images of skin: a short review. Biomed Eng Comput Biol 8:117959721771347. https://doi.org/10.1177/1179597217713475
Kislevitz M, Akgul Y, Wamsley C et al (2020) Use of optical coherence tomography (OCT) in aesthetic skin assessment—a short review. Lasers Surg Med 52:699–704. https://doi.org/10.1002/lsm.23219
Ji X, Mojahed D, Okawachi Y, Gaeta AL, Hendon CP, Lipson M (2021) Millimeter-scale chip–based supercontinuum generation for optical coherence tomography. Sci Adv 7(38):eabg8869
Maguluri G, Grimble J, Mujat M et al (2022) Fiber-based hand-held RCM-OCT probe for noninvasive assessment of skin lesions and therapy guidance. Transl Biophotonics 4:1–8. https://doi.org/10.1002/tbio.202200002
Chen TH, Lee YH, Ng CY, Tsai MT, Lee CK, Lee HC (2023) Development of an automatic algorithm enabling layer segmentation and optical characteristic analysis in skin optical coherence tomography imaging. In: Photonics in dermatology and plastic surgery 2023, vol 12352. SPIE, pp 7–10
Swanson EC, Friedly JL, Wang RK, Sanders JE (2020) Optical coherence tomography for the investigation of skin adaptation to mechanical stress. Ski Res Technol 26:627–638. https://doi.org/10.1111/srt.12843
Tsai M-R, Ho T-S, Wu Y-H, Lu C-W (2021) In vivo dual-mode full-field optical coherence tomography for differentiation of types of melanocytic nevi. J Biomed Opt 26:1–8. https://doi.org/10.1117/1.jbo.26.2.020501
McMillan L, O’Mahoney P, Feng K et al (2021) Development of a predictive Monte Carlo radiative transfer model for ablative fractional skin lasers. Lasers Surg Med 53:731–740. https://doi.org/10.1002/lsm.23335
Chen M, Feng X, Markey MK, Tunnell JW (2022) Combined reflectance confocal microscopy and Raman spectroscopy for skin cancer diagnosis. In: Microscopy histopathology and analytics. Optica Publishing Group, p MM2A-5
Gorzelanny C, Mess C, Schneider SW et al (2020) Skin barriers in dermal drug delivery: which barriers have to be overcome and how can we measure them? Pharmaceutics 12:1–31. https://doi.org/10.3390/pharmaceutics12070684
Bratchenko IA, Bratchenko LA, Moryatov AA et al (2021) In vivo diagnosis of skin cancer with a portable Raman spectroscopic device. Exp Dermatol 30:652–663. https://doi.org/10.1111/exd.14301
Ilchenko O, Pilhun Y, Kutsyk A (2022) Towards Raman imaging of centimeter scale tissue areas for real-time opto-molecular visualization of tissue boundaries for clinical applications. Light Sci Appl 11:22–24. https://doi.org/10.1038/s41377-022-00828-2
Zhang S, Bi R, Zhang R et al (2022) An all metasurface-based fiber needle probe for Raman spectroscopy. Front Phys 10:1–12. https://doi.org/10.3389/fphy.2022.1093284
Matveeva I, Bratchenko I, Khristoforova Y et al (2022) Multivariate curve resolution alternating least squares analysis of in vivo skin Raman spectra. Sensors 22. https://doi.org/10.3390/s22249588
Heng HPS, Shu C, Zheng W et al (2021) Advances in real‐time fiber‐optic Raman spectroscopy for early cancer diagnosis: pushing the frontier into clinical endoscopic applications.https://doi.org/10.1002/tbio.202000018
Zavaleta CL, Garai E, Liu JTC et al (2013) A Raman-based endoscopic strategy for multiplexed molecular imaging. Proc Natl Acad Sci U S A 110. https://doi.org/10.1073/pnas.1211309110
Khristoforova YA, Bratchenko LA, Skuratova MA, Lebedeva EA, Lebedev PA, Bratchenko IA (2023) Raman spectroscopy in chronic heart failure diagnosis based on human skin analysis. J Biophotonics 16(7):e202300016
Yang J, Zhang Z, Zhou P et al (2023) Toward a new generation of permeable skin electronics. Nanoscale 15:3051–3078. https://doi.org/10.1039/d2nr06236d
Li W, Jia J, Sun X et al (2023) A light/pressure bifunctional electronic skin based on a bilayer structure of PEDOT:PSS-coated cellulose paper/CsPbBr 3 QDs film. Polymers (Basel) 15:2136. https://doi.org/10.3390/polym15092136
Takamatsu T, Sijie Y, Shujie F et al (2020) Multifunctional high-power sources for smart contact lenses. Adv Funct Mater 30:1–8. https://doi.org/10.1002/adfm.201906225
Liu X, Ye Y, Ge Y et al (2024) Smart contact lenses for healthcare monitoring and therapy. ACS Nano 18:6817–6844. https://doi.org/10.1021/acsnano.3c12072
Kim J, Kim M, Lee M-S et al (2017) Wearable smart sensor systems integrated on soft contact lenses for wireless ocular diagnostics. Nat Commun 8:14997. https://doi.org/10.1038/ncomms14997
Jacobs DS, Carrasquillo KG, Cottrell PD et al (2021) BCLA CLEAR – medical use of contact lenses. Contact Lens Anterior Eye 44:289–329. https://doi.org/10.1016/j.clae.2021.02.002
Keum DH, Kim S-K, Koo J et al (2020) Wireless smart contact lens for diabetic diagnosis and therapy. Sci Adv 6. https://doi.org/10.1126/sciadv.aba3252
Lee S, Jo I, Kang S et al (2017) Smart contact lenses with graphene coating for electromagnetic interference shielding and dehydration protection. ACS Nano 11:5318–5324. https://doi.org/10.1021/acsnano.7b00370
Lei M, Feng K, Ding S et al (2022) Breathable and waterproof electronic skin with three-dimensional architecture for pressure and strain sensing in nonoverlap** mode. ACS Nano 16:12620–12634. https://doi.org/10.1021/acsnano.2c04188
Wang R, Feng S, Wang Y et al (2023) A transparent, and self-healable strain-sensor e-skin based on polyurethane membrane with silver nanowires. Coatings 13:829. https://doi.org/10.3390/coatings13050829
Park J, Kim J, Kim SY et al (2018) Soft, smart contact lenses with integrations of wireless circuits, glucose sensors, and displays. Sci Adv 4:1–12. https://doi.org/10.1126/sciadv.aap9841
Guo S, Wu K, Li C et al (2021) Integrated contact lens sensor system based on multifunctional ultrathin MoS2 transistors. Matter 4:969–985. https://doi.org/10.1016/j.matt.2020.12.002
El Turk S, Tarnini M, Al Hassanieh S et al (2024) Implementation of the seeded growth method in fabricating 3D-printed nanocomposite contact lenses for selective transmission. Adv Eng Mater 26:2301093. https://doi.org/10.1002/adem.202301093
Mirzajani H, Mirlou F, Istif E et al (2022) Powering smart contact lenses for continuous health monitoring: recent advancements and future challenges. Biosens Bioelectron 197:113761. https://doi.org/10.1016/j.bios.2021.113761
Lee K, Cavalcanti TC, Kim S et al (2023) Multi-task and few-shot learning-based fully automatic deep learning platform for mobile diagnosis of skin diseases. IEEE J Biomed Heal Informatics 27:176–187. https://doi.org/10.1109/JBHI.2022.3193685
Kumari J, Das K, Goldust M (2023) Metaverse in diagnosis of skin diseases. J Cosmet Dermatol 22:698–699. https://doi.org/10.1111/jocd.15409
Seah D, Cheng Z, Vendrell M (2023) Fluorescent probes for imaging in humans: where are we now? ACS Nano 17:19478–19490. https://doi.org/10.1021/acsnano.3c03564
Reichel D, Sagong B, Teh J et al (2020) Near infrared fluorescent nanoplatform for targeted intraoperative resection and chemotherapeutic treatment of glioblastoma. ACS Nano 14:8392–8408. https://doi.org/10.1021/acsnano.0c02509
Leiloglou M, Kedrzycki MS, Chalau V et al (2022) Indocyanine green fluorescence image processing techniques for breast cancer macroscopic demarcation. Sci Rep 12:1–15. https://doi.org/10.1038/s41598-022-12504-x
Rennie MY, Dunham D, Lindvere-Teene L et al (2019) Understanding real-time fluorescence signals from bacteria and wound tissues observed with the MolecuLight i:XTM. Diagnostics 9. https://doi.org/10.3390/diagnostics9010022
**ao P (2016) Photothermal radiometry for skin research. Cosmetics 3. https://doi.org/10.3390/cosmetics3010010
Al-Kinani MA, Haider AJ, Al-Musawi S (2021) Study the effect of laser wavelength on polymeric metallic nanocarrier synthesis for curcumin delivery in prostate cancer therapy: in vitro study. J Appl Sci Nanotechnol 1:43–50. https://doi.org/10.53293/jasn.2021.11023
Shakaty A, Hmood J, Mahdi B (2022) Characterizations of nanodiamond composite film for photonics applications. J Appl Sci Nanotechnol 2:52–63. https://doi.org/10.53293/jasn.2022.4350.1101
Iorizzo TW, Jermain PR, Salomatina E et al (2021) Temperature induced changes in the optical properties of skin in vivo. Sci Rep 11:1–9. https://doi.org/10.1038/s41598-020-80254-9
Overchuk M, Weersink RA, Wilson BC, Zheng G (2023) Photodynamic and photothermal therapies: synergy opportunities for nanomedicine. ACS Nano 17:7979–8003. https://doi.org/10.1021/acsnano.3c00891
Ai X, Wang Y (2022) The cube surface light field for interactive free-viewpoint rendering. Appl Sci 12. https://doi.org/10.3390/app12147212
Yin J, Xu X-l, **ong X-h, Marszałek Z (2022) An enhancement method of waveform simulation in dual-color laser field imaging based on Internet of Things. Mob Networks Appl. https://doi.org/10.1007/s11036-021-01903-5
Ismara KI, Surwi F, Thoyyibah N (2022) Development of augmented reality based occupational health and safety guidebook in electricity basic laboratory. Int J Health Sci (Qassim) 6:11377–11395. https://doi.org/10.53730/ijhs.v6ns5.11025
Jeong K-J, Gwak J, Wang C et al (2022) Chirality of fingerprints: pattern- and curvature-induced emerging chiroptical properties of elastomeric grating meta-skin. ACS Nano 16:6103–6110. https://doi.org/10.1021/acsnano.1c11597
Vázquez-Iglesias L, Stanfoca Casagrande GM, García-Lojo D et al (2024) SERS sensing for cancer biomarker: approaches and directions. Bioact Mater 34:248–268. https://doi.org/10.1016/j.bioactmat.2023.12.018
Sisignano M, Lötsch J, Parnham MJ, Geisslinger G (2019) Potential biomarkers for persistent and neuropathic pain therapy. Pharmacol Ther 199:16–29. https://doi.org/10.1016/j.pharmthera.2019.02.004
Gupta A, Mathew R, Anand A et al (2024) A DNA aptamer-based assay for the detection of soluble ST2, a prognostic biomarker for monitoring heart failure. Int J Biol Macromol 256:128295. https://doi.org/10.1016/j.ijbiomac.2023.128295
Chaudhury S, Sau K (2023) A blockchain-enabled internet of medical things system for breast cancer detection in healthcare. Healthc Anal 4:100221. https://doi.org/10.1016/j.health.2023.100221
Chaudhary S, Kakkar R, Jadav NK et al (2022) A taxonomy on smart healthcare technologies: security framework, case study, and future directions. J Sensors 2022:1–30. https://doi.org/10.1155/2022/1863838
Sempionatto JR, Lin M, Yin L et al (2021) An epidermal patch for the simultaneous monitoring of haemodynamic and metabolic biomarkers. Nat Biomed Eng 5:737–748. https://doi.org/10.1038/s41551-021-00685-1
Paranjape M, Garra J, Brida S et al (2003) A PDMS dermal patch for non-intrusive transdermal glucose sensing. Sensors Actuators A Phys 104:195–204. https://doi.org/10.1016/S0924-4247(03)00049-9
Chen H, Dejace L, Lacour SP (2021) Electronic skins for healthcare monitoring and smart prostheses. Annu Rev Control Robot Auton Syst 4:629–650. https://doi.org/10.1146/annurev-control-071320-101023
Yu C, Shah A, Amiri N et al (2023) A conformable ultrasound patch for cavitation‐enhanced transdermal cosmeceutical delivery. Adv Mater 35. https://doi.org/10.1002/adma.202300066
Wang C, He T, Zhou H et al (2023) Artificial intelligence enhanced sensors - enabling technologies to next-generation healthcare and biomedical platform. Bioelectron Med 9:17. https://doi.org/10.1186/s42234-023-00118-1
Zheng H, Mei P, Wang W et al (2023) Effects of super absorbent polymer on crop yield, water productivity and soil properties: a global meta-analysis. Agric Water Manag 282:108290. https://doi.org/10.1016/j.agwat.2023.108290
Kim S, Day CM, Song Y et al (2023) Innovative topical patches for non-melanoma skin cancer: current challenges and key formulation considerations. Pharmaceutics 15:2577. https://doi.org/10.3390/pharmaceutics15112577
Rybak D, Su Y-C, Li Y et al (2023) Evolution of nanostructured skin patches towards multifunctional wearable platforms for biomedical applications. Nanoscale 15:8044–8083. https://doi.org/10.1039/D3NR00807J
Elragal R, Elragal A, Habibipour A (2023) Healthcare analytics—a literature review and proposed research agenda. Front Big Data 6. https://doi.org/10.3389/fdata.2023.1277976
Gao X, Chen X, Hu H et al (2022) A photoacoustic patch for three-dimensional imaging of hemoglobin and core temperature. Nat Commun 13:7757. https://doi.org/10.1038/s41467-022-35455-3
Guk K, Han G, Lim J et al (2019) Evolution of wearable devices with real-time disease monitoring for personalized healthcare. Nanomaterials 9:813. https://doi.org/10.3390/nano9060813
Yuan X, Ouaskioud O, Yin X et al (2023) Epidermal wearable biosensors for the continuous monitoring of biomarkers of chronic disease in interstitial fluid. Micromachines 14:1452. https://doi.org/10.3390/mi14071452
Smith AA, Li R, Tse ZTH (2023) Resha** healthcare with wearable biosensors. Sci Rep 13:4998. https://doi.org/10.1038/s41598-022-26951-z
Zhu Y, Haghniaz R, Hartel MC et al (2023) A breathable, passive‐cooling, non‐inflammatory, and biodegradable aerogel electronic skin for wearable physical‐electrophysiological‐chemical analysis. Adv Mater 35. https://doi.org/10.1002/adma.202209300
Dervisevic M, Alba M, Prieto-Simon B, Voelcker NH (2020) Skin in the diagnostics game: wearable biosensor nano- and microsystems for medical diagnostics. Nano Today 30:100828. https://doi.org/10.1016/j.nantod.2019.100828
Manikkath J, Subramony JA (2021) Toward closed-loop drug delivery: integrating wearable technologies with transdermal drug delivery systems. Adv Drug Deliv Rev 179:113997. https://doi.org/10.1016/j.addr.2021.113997
Rubins U, Marcinkevics Z, Cimurs J et al (2019) Multimodal device for real-time monitoring of skin oxygen saturation and microcirculation function. Biosensors 9:97. https://doi.org/10.3390/bios9030097
Kazanskiy NL, Khonina SN, Butt MA (2024) A review on flexible wearables-recent developments in non-invasive continuous health monitoring. Sensors Actuators A Phys:114993. https://doi.org/10.1016/j.sna.2023.114993
Sun C, Bu N, Hu X (2023) Recent trends in electronic skin for transdermal drug delivery. Intell Pharm 1:183–191. https://doi.org/10.1016/j.ipha.2023.08.001
Wong SHD, Deen GR, Bates JS et al (2023) Smart skin‐adhesive patches: from design to biomedical applications. Adv Funct Mater 33. https://doi.org/10.1002/adfm.202213560
Seo YJ, Kwon KH (2022) An application of AR in cosmetological industry after coronavirus disease-19 pandemic. J Cosmet Dermatol 21:5314–5320
Chidambaram S, Stifano V, Demetres M et al (2021) Applications of augmented reality in the neurosurgical operating room: a systematic review of the literature. J Clin Neurosci 91:43–61
Iqbal MA, Saleh A, Darwito HA (2020) Implementation of the introduction of skin diseases based on augmented reality. IES 2020 - Int Electron Symp Role Auton Intell Syst Hum Life Comf:406–410. https://doi.org/10.1109/IES50839.2020.9231615
Hamady M, Canale L, Kyrginas D, Yable DK, Zissis G (2023) Development of an optical analysis device using the ray tracing method for the detection of skin infections. In: 2023 IEEE sustainable smart lighting world conference & expo (LS18). IEEE, pp 1–4
Ubbink DT, Janssen HAM, Schreurs MMA, Jacobs M (1995) Capillary microscopy is a diagnostic aid in patients with acral ischemia. Angiology 46:59–64
Narayanamurthy V, Padmapriya P, Noorasafrin A et al (2018) Skin cancer detection using non-invasive techniques. RSC Adv 8:28095–28130. https://doi.org/10.1039/c8ra04164d
Sengupta K, Nagatsuma T, Mittleman DM (2018) Terahertz integrated electronic and hybrid electronic–photonic systems. Nat Electron 1:622–635. https://doi.org/10.1038/s41928-018-0173-2
Wilson BC, Eu D (2022) Optical spectroscopy and imaging in surgical management of cancer patients. Transl Biophotonics 4:1–24. https://doi.org/10.1002/tbio.202100009
Egawa M (2021) Raman microscopy for skin evaluation. Analyst 146:1142–1150. https://doi.org/10.1039/d0an02039g
Perevedentseva E, Ali N, Karmenyan A et al (2019) Optical studies of nanodiamond-tissue interaction: skin penetration and localization. Materials (Basel) 12. https://doi.org/10.3390/ma12223762
López-Dorado A, Ortiz M, Satue M et al (2021) Early diagnosis of multiple sclerosis using swept-source optical coherence tomography and convolutional neural networks trained with data augmentation. Sensors 22:167. https://doi.org/10.3390/s22010167
Min J, Tu J, Xu C et al (2023) Skin-interfaced wearable sweat sensors for precision medicine. Chem Rev 123:5049–5138. https://doi.org/10.1021/acs.chemrev.2c00823
Sempionatto JR, Lasalde-Ramírez JA, Mahato K et al (2022) Wearable chemical sensors for biomarker discovery in the omics era. Nat Rev Chem 6:899–915. https://doi.org/10.1038/s41570-022-00439-w
Yang Y, Song Y, Bo X et al (2020) A laser-engraved wearable sensor for sensitive detection of uric acid and tyrosine in sweat. Nat Biotechnol 38:217–224. https://doi.org/10.1038/s41587-019-0321-x
Yu Y, Nassar J, Xu C et al (2020) Biofuel-powered soft electronic skin with multiplexed and wireless sensing for human-machine interfaces. Sci Robot 5:1–13. https://doi.org/10.1126/SCIROBOTICS.AAZ7946
Tao Y, Rajapakse A, Erickson A (2022) Advanced antireflection for back-illuminated silicon photomultipliers to detect faint light. Sci Rep 12:1–10. https://doi.org/10.1038/s41598-022-18280-y
Gautam V, Trivedi NK, Anand A et al (2023) Early skin disease identification using deep neural network. Comput Syst Sci Eng 44:2259–2275. https://doi.org/10.32604/csse.2023.026358
Kim JJ, Wang Y, Wang H, Lee S, Yokota T, Someya T (2021) Skin electronics: next‐generation device platform for virtual and augmented reality. Adv Funct Mater 31(39):2009602
Al MM, Uddin MS (2021) Hybrid methodologies for segmentation and classification of skin diseases: a study. J Comput Commun 09:67–84. https://doi.org/10.4236/jcc.2021.94005
Bancel E, Genier E, Santagata R et al (2023) All-fiber frequency agile triple-frequency comb light source. Nat Commun 14:7953. https://doi.org/10.1038/s41467-023-43734-w
Amiri IS, Azzuhri SR Bin, Jalil MA et al (2018) Introduction to photonics: principles and the most recent applications of microstructures. Micromachines 9. https://doi.org/10.3390/mi9090452
Lederman JC, Zhang W, de Lima TF et al (2023) Real-time photonic blind interference cancellation. Nat Commun 14:1–10. https://doi.org/10.1038/s41467-023-43982-w
Brueck SR (2004) Photonics in nanotechnology. In: Photonic applications systems technologies conference. Optica Publishing Group, p PMA2
Delmas P, Hao J, Rodat-Despoix L (2011) Molecular mechanisms of mechanotransduction in mammalian sensory neurons. Nat Rev Neurosci 12:139–153. https://doi.org/10.1038/nrn2993
Yu S, Zhou P, ** W et al (2023) General deep learning framework for emissivity engineering. Light Sci Appl 12. https://doi.org/10.1038/s41377-023-01341-w
Yang Y, Chapman RJ, Haylock B et al (2024) Programmable high-dimensional Hamiltonian in a photonic waveguide array. Nat Commun 15:50. https://doi.org/10.1038/s41467-023-44185-z
Qian L, Wu JY, Dimaio SP et al (2020) A review of augmented reality in robotic-assisted surgery. IEEE Trans Med Robot Bionics 2:1–16. https://doi.org/10.1109/TMRB.2019.2957061
Wendler T, van Leeuwen FWB, Navab N, van Oosterom MN (2021) How molecular imaging will enable robotic precision surgery: the role of artificial intelligence, augmented reality, and navigation. Eur J Nucl Med Mol Imaging 48:4201–4224. https://doi.org/10.1007/s00259-021-05445-6
Chen J, Fu Y, Lu W, Pan Y (2023) Augmented reality-enabled human-robot collaboration to balance construction waste sorting efficiency and occupational safety and health. J Environ Manage 348:119341. https://doi.org/10.1016/j.jenvman.2023.119341
Acknowledgements
The authors would like to extend gratitude towards Photonics Technology Research Group, Lab, Pusat Kejuruteraan Elektronik Dan Komunikasi Terkehadapan (PAKET), Faculty of Engineering and Build Environment, Universiti Kebangsaan Malaysia. The authors extend their appreciation to the Deanship of Scientific Research at Northern Border University, Arar, KSA for funding this research work through the project number NBU-FFR-2024-1299-05, as well as the University of Technology, Baghdad, Iraq.
Funding
The authors acknowledge the Fundamental Research Grant Scheme (FRGS), grant number FRGS/1/2021/TK0/UKM/02/17 funded by the Ministry of Higher Education (MOHE) Malaysia, and Ganjaran Penerbitan, grant number GP-K013436, Universiti Kebangsaan Malaysia.
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B.A.T.: wrote the initial manuscript draft, conceptualization, and methodology. A.J.A.: wrote the initial manuscript draft, analysis and critical evaluation, and review and editing. A.J.H. and A.SA.: investigation, conceptualization, and methodology. V.C.: writing—review and editing. N.A.: supervision and validation. All authors have reviewed and accepted the published version of the manuscript.
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Taha, B.A., Addie, A.J., Kadhim, A.C. et al. Photonics-powered augmented reality skin electronics for proactive healthcare: multifaceted opportunities. Microchim Acta 191, 250 (2024). https://doi.org/10.1007/s00604-024-06314-3
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DOI: https://doi.org/10.1007/s00604-024-06314-3