Abstract
The key to develo** sensors for chiral drug determination is to exclude interference from enantiomers. In this study, metal–organic frameworks (MOFs) and molecularly imprinted polymer (MIP) were introduced to prepare a chiral sensor for levofloxacin detection. The MIP was electropolymerised on the surface of the Cu/Fe-benzene-1,3,5-tricarboxylate MOF (Cu/Fe-BTC)-modified Au electrode using levofloxacin as a template molecule. After eluting the levofloxacin, a chiral sensor with recognition sites for levofloxacin was obtained. With this site as a switch, a novel method for detecting levofloxacin was established. Because of the enhanced recognition effect, the sensor can effectively exclude the enantiomeric interference of d-ofloxacin. Moreover, Cu/Fe-BTC can effectively amplify the current response signal and improve the sensitivity of the sensor. The linear range of the sensor was 5 to 4000 × 10−11 mol L−1, and the detection limit was 2.07 × 10−11 mol L−1. When applied to detecting levofloxacin in actual samples, the sensor showed a 92.7–109.8% recovery.
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Funding
This study was supported by the Chinese Academy of Tropical Agricultural Sciences for Science and Technology Innovation Team of National Tropical Agricultural Science Center (CATASCXTD202314); the CARS (CARS-31); the Key Laboratory of Tropical Fruits and Vegetables Quality and Safety for State Market Regulation (ZX-2023002); and the Hainan Province Science and Technology Special Fund (ZDYF2022XDNY232).
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Deng, Y., Li, S., Ma, X. et al. Electrochemical chiral sensor for levofloxacin detection base on Cu/Fe-BTC amplification. Microchim Acta 190, 435 (2023). https://doi.org/10.1007/s00604-023-06009-1
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DOI: https://doi.org/10.1007/s00604-023-06009-1