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Au-doped MOFs catalyzed electrochemiluminescence platform coupled with target-induced self-enrichment for detection of synthetic cannabinoid RCS-4

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Abstract

A ternary composite material with Au, Co-based organic frameworks (ZIF-67) and perylene derivatives (PTCD-cys) has been synthesized for identification of synthetic cannabinoids. Through contact with Au–S, Au-ZIF-67 increased electrochemiluminescence (ECL) sensitivity and stability and efficiently catalyzed the ECL of PTCD-cys. Compared with the ECL response of PTCD-cys monomer, the ECL signal value of the composite material was significantly increased, and the onset potential of Au-ZIF-67/PTCD-cys favorably shifted more than that of PTCD-cys/GCE. When the target cannabinoid molecule RCS-4 appeared, Au-ZIF-67 captured and immobilized it on the sensor surface by adsorption to achieve target-induced self-enrichment of RCS-4. Under optimal conditions, the ECL sensor was found to be linearly related to the logarithm of the RCS-4 concentration ranging from 3.1 × 10−15 to 3.1 × 10−9 mol/L with a detection limit (LOD) of 6.0 × 10−16 mol/L (S/N = 3). The approach had the advantages of being simple to use, having a high sensitivity, a wide detection range, and good stability, making it a novel platform for RSC-4 detection in public health safety monitoring.

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Funding

This work was financially supported by the National Natural Science Foundation of China (51874050 and 21904014), the Jiangsu Higher Education Institutions of China (19KJB150003), the Natural Science Foundation of Jiangsu Province (BK20190928), the Foundation of Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology (BM2012110).

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Authors and Affiliations

  1. Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, School of Petrochemical Engineering, Changzhou University, Changzhou, 213164, China

    Qianying Cao, Ding Jiang, Fangmin Xu, **g Wen, Wenchang Wang & Zhidong Chen

  2. Advanced Catalysis and Green Manufacturing Collaborative Innovation Center, Changzhou University, Changzhou, 213164, China

    Ding Jiang, Fangmin Xu, Wenchang Wang & Zhidong Chen

  3. Department of Applied Chemistry, Osaka Prefecture University, Naka Ku, 1-2 Gakuen, Sakai, Osaka, 5998570, Japan

    Hiroshi Shiigi

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  1. Qianying Cao
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Cao, Q., Jiang, D., Xu, F. et al. Au-doped MOFs catalyzed electrochemiluminescence platform coupled with target-induced self-enrichment for detection of synthetic cannabinoid RCS-4. Microchim Acta 189, 313 (2022). https://doi.org/10.1007/s00604-022-05397-0

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