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Voltammetric determination of levofloxacin using silver nanoparticles deposited on a thin nickel oxide porous film

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Abstract

The authors describe a simplified chemical precipitation method and silver mirror reaction to synthesize a nanocomposite consiting of silver nanoparticles on a thin and porous nickel oxide film. Placed on a glassy carbon electrode (GCE), it allows for the determination of levofloxacin (LEV) via square wave voltammetry (SWV). Under optimal detection conditions, the voltammetric signal (typically measured at around 0.96 V vs. SCE) increases linearly in the 0.25–100 μM LEV concentration range. And the detection limit was calculated as 27 nM (at S/N = 3). The sensor is highly selective, stable and repeatable. It was applied to the determination of LEV in spiked human serum samples, and the satisfactory results confirm the applicability of this sensor to practical analyses.

Schematic of a two-step method to synthesize a nanocomposite consisting of nickel oxide porous thin-film supported silver nanoparticles. The composite was used for improved voltammetric determination of levofloxacin.

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Acknowledgments

This work was supported by National Natural Science Foundation of China (No. 21475022, 21505019), the Natural Science Foundations of Guangdong Province (No.2015A030310272), Technology Planning Project of Guangdong Province (No.2015B090927007). Guangdong Provincial Key Platform and Major Scientific Research Projects for Colleges and Universities (No. 2015KCXTD029).

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Authors and Affiliations

  1. Guangdong Engineering and Technology Research Center for Advanced Nanomaterials, School of Environment and Civil Engineering, Dongguan University of Technology, Dongguan, 523808, People’s Republic of China

    Chaoqiao Liu, Dong **e, Peng Liu, Shilei **e, Shoushan Wang, Faliang Cheng & Min Zhang

  2. School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510641, People’s Republic of China

    Chaoqiao Liu & Lishi Wang

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  1. Chaoqiao Liu
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  2. Dong **e
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  3. Peng Liu
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  5. Shoushan Wang
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  7. Min Zhang
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Correspondence to Min Zhang or Lishi Wang.

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Liu, C., **e, D., Liu, P. et al. Voltammetric determination of levofloxacin using silver nanoparticles deposited on a thin nickel oxide porous film. Microchim Acta 186, 21 (2019). https://doi.org/10.1007/s00604-018-3146-2

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