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The use of the Core Yellow Flags Index for the assessment of psychosocial distress in patients undergoing surgery of the cervical spine

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Abstract

Background

Psychosocial distress (the presence of yellow flags) has been linked to poor outcomes in spine surgery. The Core Yellow Flags Index (CYFI), a short instrument assessing the 4 main yellow flags, was developed for use in patients undergoing lumbar spine surgery. This study evaluated its ability to predict outcome in patients undergoing cervical spine surgery.

Methods

Patients with degenerative spinal disorders (excluding myelopathy) operated in one centre, from 2015 to 2019, were asked to complete the CYFI at baseline and the Core Outcome Measures Index (COMI) at baseline and 3 and 12 months after surgery. The relationship between CYFI and COMI scores at baseline as well as the predictive ability of the CYFI on the COMI follow-up scores were tested using structural equation modelling.

Results

From 731 eligible patients, 547 (61.0 ± 12.5 years; 57.2% female) completed forms at all three timepoints. On a cross-sectional basis, preoperative CYFI and COMI scores were highly correlated (β = 0.54, in men and 0.51 in women; each p < 0.001). CYFI added significantly and independently to the prediction of COMI at 3 months’ FU in men (β = 0.36) and 12 months’ FU in men and women (both β = 0.20) (all p < 0.001).

Conclusion

The CYFI had a low to moderate but significant and independent association with cervical spine surgery outcomes. Implementing the CYFI in the preoperative workup of these patients could help refine outcome predictions and better manage patient expectations.

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References

  1. Chen Z, Luo R, Yang Y, **ang Z (2021) The prevalence of depression in degenerative spine disease patients: a systematic review and meta-analysis. Eur Spine J: Off Publ Eur Spine Soc, Eur Spinal Deform Soc, Eur Sect Cerv Spine Res Soc 30:3417–3427. https://doi.org/10.1007/s00586-021-06977-z

    Article  Google Scholar 

  2. Jiménez-Almonte JH, Hautala GS, Abbenhaus EJ, Grabau JD, Nzegwu IN, Mehdi SK, Akhtar ZM, Liu B, Jacobs CA, Cassidy RC (2020) Spine patients demystified: what are the predictive factors of poor surgical outcome in patients after elective cervical and lumbar spine surgery? Spine J: Off J North Am Spine Soc 20:1529–1534. https://doi.org/10.1016/j.spinee.2020.05.550

    Article  Google Scholar 

  3. Kendall NA (1999) Psychosocial approaches to the prevention of chronic pain: the low back paradigm. Baillieres Best Pract Res Clin Rheumatol 13:545–554. https://doi.org/10.1053/berh.1999.0044

    Article  CAS  PubMed  Google Scholar 

  4. Havakeshian S, Mannion AF (2013) Negative beliefs and psychological disturbance in spine surgery patients: a cause or consequence of a poor treatment outcome? Eur Spine J 22:2827–2835. https://doi.org/10.1007/s00586-013-2822-5

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. den Boer JJ, Oostendorp RA, Beems T, Munneke M, Oerlemans M, Evers AW (2006) A systematic review of bio-psychosocial risk factors for an unfavourable outcome after lumbar disc surgery. Eur Spine J: Off Publ Eur Spine Soc, Eur Spinal Deform Soc, Eur Sect Cerv Spine Res Soc 15:527–536. https://doi.org/10.1007/s00586-005-0910-x

    Article  Google Scholar 

  6. Aalto TJ, Malmivaara A, Kovacs F, Herno A, Alen M, Salmi L, Kroger H, Andrade J, Jimenez R, Tapaninaho A, Turunen V, Savolainen S, Airaksinen O (2006) Preoperative predictors for postoperative clinical outcome in lumbar spinal stenosis: systematic review. Spine 31:E648-663. https://doi.org/10.1097/01.brs.0000231727.88477.da

    Article  PubMed  Google Scholar 

  7. Mayo BC, Massel DH, Bohl DD, Narain AS, Hijji FY, Long WW, Modi KD, Basques BA, Yacob A, Singh K (2017) Preoperative mental health status may not be predictive of improvements in patient-reported outcomes following an anterior cervical discectomy and fusion. J Neurosurg Spine 26:177–182. https://doi.org/10.3171/2016.7.spine16472

    Article  PubMed  Google Scholar 

  8. Skeppholm M, Fransson R, Hammar M, Olerud C (2017) The association between preoperative mental distress and patient-reported outcome measures in patients treated surgically for cervical radiculopathy. Spine J: Off J North Am Spine Soc 17:790–798. https://doi.org/10.1016/j.spinee.2016.02.037

    Article  Google Scholar 

  9. Sivaganesan A, Khan I, Pennings JS, Roth SG, Nolan ER, Oleisky ER, Asher AL, Bydon M, Devin CJ, Archer KR (2020) Why are patients dissatisfied after spine surgery when improvements in disability and pain are clinically meaningful? Spine J: Off J North Am Spine Soc. https://doi.org/10.1016/j.spinee.2020.06.008

    Article  Google Scholar 

  10. Harris AB, Marrache M, Puvanesarajah V, Raad M, Jain A, Kebaish KM, Riley LH, Skolasky RL (2020) Are preoperative depression and anxiety associated with patient-reported outcomes, health care payments, and opioid use after anterior discectomy and fusion? Spine J: Off J North Am Spine Soc 20:1167–1175. https://doi.org/10.1016/j.spinee.2020.03.004

    Article  Google Scholar 

  11. Goh GS, Liow MHL, Yeo W, Ling ZM, Guo CM, Yue WM, Tan SB, Chen LTJ (2019) Poor baseline mental health does not influence improvement in patient-reported outcomes, satisfaction, and return to work two years after single-level anterior cervical discectomy and fusion. Spine 44:839–847. https://doi.org/10.1097/brs.0000000000002960

    Article  PubMed  Google Scholar 

  12. Cha EDK, Lynch CP, Parrish JM, Jenkins NW, Geoghegan CE, Jadczak CN, Mohan S, Singh K (2021) Role of gender in improvement of depressive symptoms among patients undergoing cervical spine procedures. Neurospine 18:217–225. https://doi.org/10.14245/ns.2040610.305

    Article  PubMed  PubMed Central  Google Scholar 

  13. Wagner A, Shiban Y, Zeller L, Aftahy K, Lange N, Motov S, Joerger AK, Meyer B, Shiban E (2020) Psychological predictors of quality of life after anterior cervical discectomy and fusion for degenerative cervical spine disease. Sci Rep 10:13415. https://doi.org/10.1038/s41598-020-70437-9

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Mannion AF, Mariaux F, Reitmeir R, Fekete TF, Haschtmann D, Loibl M, Jeszenszky D, Kleinstück FS, Porchet F, Elfering A (2020) Development of the “Core Yellow Flags Index” (CYFI) as a brief instrument for the assessment of key psychological factors in patients undergoing spine surgery. Eur spine J: Off Publ Eur Spine Soc, the Eur Spinal Deform Soc, Eur Sect Cerv Spine Res Soc 29:1935–1952. https://doi.org/10.1007/s00586-020-06462-z

    Article  Google Scholar 

  15. Müller D, Haschtmann D, Fekete TF, Kleinstück F, Reitmeir R, Loibl M, O’Riordan D, Porchet F, Jeszenszky D, Mannion AF (2022) Development of a machine-learning based model for predicting multidimensional outcome after surgery for degenerative disorders of the spine. Eur Spine J: Off Publ Eur Spine Soc, Eur Spinal Deform Soc, Eur Sect Cerv Spine Res Soc 31:2125–2136. https://doi.org/10.1007/s00586-022-07306-8

    Article  Google Scholar 

  16. Mannion AF, Porchet F, Kleinstück FS, Lattig F, Jeszenszky D, Bartanusz V, Dvorak J, Grob D (2009) The quality of spine surgery from the patient’s perspective. Part 1: the Core Outcome Measures Index in clinical practice. Eur Spine J: Off Publ Eur Spine Soc, Eur Spinal Deform Soc, Eur Sect Cerv Spine Res Soc 3:367–373. https://doi.org/10.1007/s00586-009-0942-84

    Article  Google Scholar 

  17. Mannion AF, Elfering A, Staerkle R, Junge A, Grob D, Semmer NK, Jacobshagen N, Dvorak J, Boos N (2005) Outcome assessment in low back pain: how low can you go? Eur Spine J: Off Publ Eur Spine Soc, Eur Spinal Deform Soc, Eur Sect Cerv Spine Res Soc 14:1014–1026. https://doi.org/10.1007/s00586-005-0911-9

    Article  Google Scholar 

  18. Streiner DL, Norman GR (1995) Health measurement scales: a practical guide to their development and use. Oxford University Press Inc., Oxford, UK

    Google Scholar 

  19. Cohen J (1977) Statistical power analysis for the behavioral sciencies, Revised. Academic Press, San Diego

    Google Scholar 

  20. Schermelleh-Engel K, Moosbrugger H, Müller H (2003) Evaluating the fit of structural equation models: tests of significance and descriptive goodness-of-fit measures. Methods Psychol Res Online 8:23–74

    Google Scholar 

  21. Seebach CL, Kirkhart M, Lating JM, Wegener ST, Song Y, Riley LH 3rd, Archer KR (2012) Examining the role of positive and negative affect in recovery from spine surgery. Pain 153:518–525. https://doi.org/10.1016/j.pain.2011.10.012

    Article  PubMed  Google Scholar 

  22. MacDowall A, Skeppholm M, Lindhagen L, Robinson Y, Olerud C (2018) Effects of preoperative mental distress versus surgical modality, arthroplasty, or fusion on long-term outcome in patients with cervical radiculopathy. J Neurosurg: Spine SPI 29:371–379. https://doi.org/10.3171/2018.2.Spine171378

    Article  Google Scholar 

  23. Alvin MD, Miller JA, Lubelski D, Nowacki AS, Scheman J, Mathews M, McGirt MJ, Benzel EC, Mroz TE (2016) The impact of preoperative depression and health state on quality-of-life outcomes after anterior cervical diskectomy and fusion. Glob Spine J 6:306–313. https://doi.org/10.1055/s-0035-1562932

    Article  Google Scholar 

  24. Stephens BF, McKeithan LJ, Waddell WH, Romano J, Steinle AM, Vaughan WE, Pennings JS, Nian H, Khan I, Bydon M, Zuckerman SL, Archer KR, Abtahi AM (2023) A clinical model to predict postoperative improvement in sub-domains of the modified Japanese orthopedic association score for degenerative cervical myelopathy. Eur Spine J: Off Publ Eur Spine Soc, Eur Spinal Deform Soc, Eur Sect Cerv Spine Res Soc. https://doi.org/10.1007/s00586-023-07607-6

    Article  Google Scholar 

  25. Mjåset C, Solberg TK, Zwart JA, Småstuen MC, Kolstad F, Grotle M (2023) Anterior surgical treatment for cervical degenerative radiculopathy: a prediction model for non-success. Acta Neurochir 165:145–157. https://doi.org/10.1007/s00701-022-05440-2

    Article  PubMed  Google Scholar 

  26. Toci GR, Lambrechts MJ, Karamian BA, Mao J, Heinle J, Bhatt S, Harlamova D, Canseco JA, Kaye ID, Woods BI, Hilibrand AS, Kepler CK, Vaccaro AR, Schroeder GD (2022) Depression increases posterior cervical decompression and fusion revision rates and diminishes neck disability index improvement. Spine 47:1287–1294. https://doi.org/10.1097/brs.0000000000004371

    Article  PubMed  Google Scholar 

  27. Hébert JJ, Adams T, Cunningham E, El-Mughayyar D, Manson N, Abraham E, Wedderkopp N, Bigney E, Richardson E, Vandewint A, Small C, Kolyvas G, Roux AL, Robichaud A, Weber MH, Fisher C, Dea N, Plessis SD, Charest-Morin R, Christie SD, Bailey CS, Rampersaud YR, Johnson MG, Paquet J, Nataraj A, LaRue B, Hall H, Attabib N (2023) Prediction of 2-year clinical outcome trajectories in patients undergoing anterior cervical discectomy and fusion for spondylotic radiculopathy. J Neurosurg Spine 38:56–65. https://doi.org/10.3171/2022.7.Spine22592

    Article  PubMed  Google Scholar 

  28. Mangan JJ 3rd, Tadley M, Divi SN, Stull JD, Goyal DKC, McKenzie JC, Casper DS, Galetta MS, Kaye ID, Kurd MF, Woods BI, Radcliff KE, Rihn JA, Anderson DG, Hilibrand AS, Kepler CK, Vaccaro AR, Schroeder GD (2020) The impact of multiple comorbid mental health disorders on health-related quality of life following ACDF. Clin spine surg 33:E472-e477. https://doi.org/10.1097/bsd.0000000000000957

    Article  PubMed  Google Scholar 

  29. Archer KR, Wegener ST, Seebach C, Song Y, Skolasky RL, Thornton C, Khanna AJ, Riley LH 3rd (2011) The effect of fear of movement beliefs on pain and disability after surgery for lumbar and cervical degenerative conditions. Spine 36:1554–1562. https://doi.org/10.1097/BRS.0b013e3181f8c6f4

    Article  PubMed  Google Scholar 

  30. Mannion AF, Elfering A, Staerkle R, Junge A, Grob D, Dvorak J, Jacobshagen N, Semmer NK, Boos N (2007) Predictors of multidimensional outcome after spinal surgery. Eur Spine J: Off Publ Eur Spine Soc, Eur Spinal Deform Soc, Eur Sect Cerv Spine Res Soc 16:777–786. https://doi.org/10.1007/s00586-006-0255-0

    Article  CAS  Google Scholar 

  31. Diebo BG, Tishelman JC, Horn S, Poorman GW, Jalai C, Segreto FA, Bortz CA, Gerling MC, Lafage V, White AP, Mok JM, Cha TD, Eastlack RK, Radcliff KE, Paulino CB, Passias PG (2018) The impact of mental health on patient-reported outcomes in cervical radiculopathy or myelopathy surgery. J Clin Neurosci: Off J Neurosurg Soc Australasia 54:102–108. https://doi.org/10.1016/j.jocn.2018.06.014

    Article  Google Scholar 

  32. Phan K, Moran D, Kostowski T, Xu R, Goodwin R, Elder B, Ramhmdani S, Bydon A (2017) Relationship between depression and clinical outcome following anterior cervical discectomy and fusion. J spine surg 3:133–140. https://doi.org/10.21037/jss.2017.05.02

    Article  PubMed  PubMed Central  Google Scholar 

  33. Diebo BG, Lavian JD, Liu S, Shah NV, Murray DP, Beyer GA, Segreto FA, Maffucci F, Poorman GW, Cherkalin D, Torre B, Vasquez-Montes D, Yoshihara H, Cukor D, Naziri Q, Passias PG, Paulino CB (2018) The impact of comorbid mental health disorders on complications following cervical spine surgery with minimum 2-year surveillance. Spine 43:1455–1462. https://doi.org/10.1097/brs.0000000000002651

    Article  PubMed  Google Scholar 

  34. Dedeogullari E, Paholpak P, Barkoh K, Lucas J, Lee L, Wang C, Hsieh PC, Wang JC, Buser Z (2017) Effect of mental health on post-operative infection rates following cervical spine fusion procedures. J Orthop 14:501–506. https://doi.org/10.1016/j.jor.2017.08.006

    Article  PubMed  PubMed Central  Google Scholar 

  35. Maratos EC, Trivedi R, Richards H, Seeley H, Laing RJC (2012) Psychological distress does not compromise outcome in spinal surgery. Br J Neurosurg 26:466–471

    Article  PubMed  Google Scholar 

  36. George SZ, Fritz JM, Erhard RE (2001) A comparison of fear-avoidance beliefs in patients with lumbar spine pain and cervical spine pain. Spine 26:2139–2145. https://doi.org/10.1097/00007632-200110010-00019

    Article  CAS  PubMed  Google Scholar 

  37. Adogwa O, Elsamadicy AA, Cheng J, Bagley C (2016) Pretreatment of anxiety before cervical spine surgery improves clinical outcomes: a prospective, single-institution experience. World Neurosurg 88:625–630. https://doi.org/10.1016/j.wneu.2015.11.014

    Article  PubMed  Google Scholar 

  38. Scarone P, Van Santbrink W, Koetsier E, Smeets A, Van Santbrink H, Peters ML (2023) The effect of perioperative psychological interventions on persistent pain, disability, and quality of life in patients undergoing spinal fusion: a systematic review. Eur Spine J: Off Publ Eur Spine Soc, Eur Spinal Deform Soc, Eur Sect Cerv Spine Res Soc 32:271–288. https://doi.org/10.1007/s00586-022-07426-1

    Article  Google Scholar 

  39. Waddell G (1987) 1987 volvo award in clinical sciences. a new clinical model for the treatment of low-back pain. Spine 12:632–644. https://doi.org/10.1097/00007632-198709000-00002

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

We thank all the patients of the Schulthess Klinik who contributed their data. We thank Dave O’Riordan, Gordana Balaban, Stéphanie Dosch, and Selina Nauer for their administration of the Spine Tango surgery forms and patient-rated outcome measures.

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Correspondence to Francine Mariaux.

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Mariaux, F., Elfering, A., Fekete, T.F. et al. The use of the Core Yellow Flags Index for the assessment of psychosocial distress in patients undergoing surgery of the cervical spine. Eur Spine J 33, 2269–2276 (2024). https://doi.org/10.1007/s00586-024-08190-0

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