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Angiotensin converting enzyme inhibitor-induced angioedema: a report of two cases

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Abstract 

Angioedema is a rare but potentially fatal side effect of angiotensin converting enzyme (ACE) inhibitors. We report for the first time, two children with systemic lupus erythematosus who developed acute angioedema after the long-term use of enalapril. Prompt recognition and appropriate management of ACE-induced angioedema prevented life-threatening complications. This report highlights the potential risks of angioedema associated with the use of ACE inhibitors in children. Patients should be advised to seek medical treatment immediately if they experience swelling of the face, neck, or tongue, and especially if they have trouble breathing, speaking, or swallowing.

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Authors and Affiliations

  1. Department of Pediatrics, Division of Nephrology, Alfred I. duPont Hospital for Children, Wilmington, Delaware, USA, , , , , , US

    F. K. Assadi, C. P. McKay, L. Hopp & D. Fattori

  2. Department of Pediatrics, Division of Anesthesia/Critical Care, Jefferson Medical College, Philadelphia, Pennsylvania, USA, , , , , , US

    H. E. Wang & S. Lawless

Authors
  1. F. K. Assadi
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  2. H. E. Wang
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  3. S. Lawless
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  4. C. P. McKay
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  5. L. Hopp
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  6. D. Fattori
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Additional information

Received: 12 March 1999 / Revised: 8 June 1999 / Accepted: 8 June 1999

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Assadi, F., Wang, H., Lawless, S. et al. Angiotensin converting enzyme inhibitor-induced angioedema: a report of two cases. Pediatr Nephrol 13, 917–919 (1999). https://doi.org/10.1007/s004670050727

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  • DOI: https://doi.org/10.1007/s004670050727

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