Abstract
Acute kidney injury (AKI) is characterized by a sudden decrease in kidney function. Children with congenital heart disease are a special group at risk of develo** AKI. We performed a systematic review of the literature to search for studies reporting the usefulness of novel urine, serum, and plasma biomarkers in the diagnosis and progression of AKI and their association with clinical outcomes in children undergoing pediatric cardiac surgery. In thirty studies, we analyzed the capacity to predict AKI and poor outcomes of five biomarkers: Cystatin C, Neutrophil gelatinase-associated lipocalin, Interleukin-18, Kidney injury molecule-1, and Liver fatty acid–binding protein. In conclusion, we suggest the need for further meta-analyses with the availability of additional studies.
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A. Cavalcante—global concept of the study, data collection, and critical review of the manuscript. B. Cavalcante—global concept of the study, manuscript writing, interpretation and discussion of data, and critical review of the manuscript. C. Branco—manuscript writing, interpretation and discussion of data. D. Chang—interpretation and discussion of data and critical review of the manuscript. E. Libório—data collection and interpretation and critical review of the manuscript. F. Maia; Pompeu; Brito and Telles—critical review of the manuscript.
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Cavalcante, C.T.d.M.B., Cavalcante, M.B., Castello Branco, K.M.P. et al. Biomarkers of acute kidney injury in pediatric cardiac surgery. Pediatr Nephrol 37, 61–78 (2022). https://doi.org/10.1007/s00467-021-05094-9
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DOI: https://doi.org/10.1007/s00467-021-05094-9