SpringerLink
Log in

A morphological and immunohistochemical study of ductal carcinoma in situ, invasive breast carcinoma of no special type, and mucinous carcinoma of the breast in comparison with solid papillary carcinoma regarding neuroendocrine marker expression

  • ORIGINAL ARTICLE
  • Published:
Virchows Archiv Aims and scope Submit manuscript

Abstract

The exact relationship between solid papillary carcinoma (SPC) and invasive breast carcinoma of no special type (IBC-NST) with neuroendocrine differentiation and SPC and mucinous carcinoma (MC) of the breast remains unclear. To clarify the relationship, we conducted a comparative study of morphological and neuroendocrine features between ductal carcinoma in situ (DCIS, 72 cases) and SPC in situ (35 cases), and IBC-NST (103 cases) and invasive SPC (92 cases). We also conducted the study between MC associated with and without SPC. Synaptophysin, chromogranin A, and INSM1 were employed for the immunohistochemical study. IBC-NST had occasionally a morphological similarity with invasive SPC. While 123 of 127 cases with SPC demonstrated diffuse staining with one or more of the neuroendocrine markers, the only one case of DCIS and none of IBC-NST showed it. Type B was observed in 16 of 18 cases of MC associated with SPC and in 13 of 33 cases of MC without it. All the cases of MC with SPC and 6 of 33 cases without it showed diffuse staining for at least one of the neuroendocrine markers. In conclusion, a careful distinction between invasive SPC and IBC-NST with neuroendocrine differentiation is required. We assume that SPC in situ is a potential candidate for precursor of IBC-NST with neuroendocrine differentiation. MC of the breast is suggested to have two pathogenetic pathways through SPC in situ or non-SPC in situ. SPC in situ is thought to be less common as a precursor of MC than non-SPC in situ.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price includes VAT (Germany)

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

Data availability

Data supporting the findings of this study are included in this published article and its supplementary information files.

References

  1. WHO Classification of Tumours Editorial Board (2019) WHO Classification of Tumours, 5th edn., Volume 2, Breast Tumours. IARC, Lyon

  2. WHO Classification of Tumours Editorial Board (2019) WHO Classification of Tumours, 5th edn., Volume 1, Digestive System Tumours. IARC, Lyon

  3. Wachter DL, Hartmann A, Beckmann MW, Fasching PA, Hein A, Bayer CM, Agaimy A (2014) Expression of neuroendocrine markers in different molecular subtypes of breast carcinoma. Biomed Res Int 2014:408459. https://doi.org/10.1155/2014/408459

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Bogina G, Munari E, Brunelli M, Bortesi L, Marconi M, Sommaggio M, Lunardi G, Gori S, Massocco A, Pegoraro MC, Zamboni G (2016) Neuroendocrine differentiation in breast carcinoma: clinicopathological features and outcome. Histopathology 68:422–432. https://doi.org/10.1111/his.12766

    Article  PubMed  Google Scholar 

  5. Otsuki Y, Suwa K, Ohtsuka S, Mori N, Yoshida M, Serizawa A, Shimizu SI, Kobayashi H (2023) A large-scale clinicopathological and long-term follow-up study of solid papillary carcinoma of the breast. Virchow Arch 482:687–695. https://doi.org/10.1007/s00428-023-03489-7

    Article  CAS  Google Scholar 

  6. Metovic J, Cascardi E, Uccella S, Maragliano R, Querzoli G, Osella-Abate S, Pittaro A, La Rosa S, Bogina G, Cassoni P, Marchiò C, Sapino A, Castellano I, Papotti M (2022) Neuroendocrine neoplasms of the breast: diagnostic agreement and impact on outcome. Virchow Arch 481:839–846. https://doi.org/10.1007/s00428-022-03426-0

    Article  Google Scholar 

  7. Karihtala P, Porvari K, Roininen N, Voutilainen S, Mattson J, Heikkilä P, Haapasaari KM, Selander K (2022) Comparison of the mutational profiles of neuroendocrine breast tumours, invasive ductal carcinomas and pancreatic neuroendocrine carcinomas. Oncogenesis 11:53. https://doi.org/10.1038/s41389-022-00427-1

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Otsuki Y, Shimizu S, Suwa K, Yoshida M, Kanzaki M, Kobayashi H (2007) Which is the better pathological prognostic factor, the Nottingham histological grade or the Japanese nuclear grade? A large- scale study with a long-term follow-up. Jpn Clin Oncol 37:266–274. https://doi.org/10.1093/jjco/hym026

    Article  Google Scholar 

  9. Goldhirsch A, Winer EP, Coates AS, Gelber RD, Piccart-Gebhart M, Thürlimann B, Senn HJ, Panel members (2013) Personalizing the treatment of women with early breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013. Ann Oncol 24:2206–23. https://doi.org/10.1093/annonc/mdt303

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Kanda Y (2013) Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics. Bone Marrow Transplant 48:452–458. https://doi.org/10.1038/bmt.2012.244

    Article  CAS  PubMed  Google Scholar 

  11. Otsuki Y, Yamada M, Shimizu S, Suwa K, Yoshida M, Tanioka F, Ogawa H, Nasuno H, Serizawa A, Kobayashi H (2007) Solid-papillary carcinoma of the breast: clinicopathological study of 20 cases. Pathol Int 57:421–429. https://doi.org/10.1111/j.1440-1827.2007.02118.x

    Article  PubMed  Google Scholar 

  12. Yamada M, Otsuki Y, Shimizu S, Tanioka F, Ogawa H, Kobayashi H (2007) Cytological study of 20 cases of solid-papillary carcinoma of the breast. Diagn Cytopathol 35:417–422. https://doi.org/10.1002/dc.20668

    Article  PubMed  Google Scholar 

  13. Yamada M, Otsuki Y, Ikeya T, Shimizu SI, Tanioka F, Ogawa H, Kobayashi H (2023) Cytological study of 44 cases with solid papillary carcinoma and a systemic review of solid papillary carcinoma and neuroendocrine tumor of the breast. Diagn Cytopathol 51:341–348. https://doi.org/10.1002/dc.25112

    Article  PubMed  Google Scholar 

  14. Tan BY, Thike AA, Ellis IO, Tan PH (2016) Am J Surg Pathol 40:1334-42. https://doi.org/10.1097/PAS.0000000000000702

  15. Moritani S, Ichihara S, Kushima R, Okabe H, Bamba M, Kobayashi TK, Hattori T (2007) Myoepithelial cells in solid variant of intraductal papillary carcinoma of the breast: a potential diagnostic pitfall and a proposal of an immunohistochemical panel in the differential diagnosis with intraductal papilloma with usual ductal hyperplasia. Virchows Arch 450:539–547. https://doi.org/10.1007/s00428-007-0402-y

    Article  PubMed  Google Scholar 

  16. Rindi G, Klimstra D, Abedi-Ardekani B, Asa S, Bosman F, Brambilla E, Busam K, de Krijger R, Dietel M, El-Naggar A, Fernandez-Cuesta L, Klőppel G, McCluggage W, Moch H, Ohgaki H, Rakha E, Reed N, Rous B, Sasano H, Scarpa A, Scoazec J-Y, Travis W, Tallini G, Trouillas J, van Krieken J, Cree I (2018) A common classification framework for neuroendocrine neoplasms: an international Agency for Research on Cancer (IARC) and World Health Organization (WHO) expert consensus proposal. Mod Pathol 31:1770–1786. https://doi.org/10.1038/s41379-018-0110-y

    Article  PubMed  PubMed Central  Google Scholar 

  17. Marchio C, Geyer F, Ng C, Piscuoglio S, De Fillippo M, Cupo M, Schultheis A, Lim R, Burke K, Guerini-Rocco E, Rapotti M, Norton L, Sapino A, Weigelt B, Reis-Filho J (2018) The genetic landscape of breast carcinomas with neuroendocrine differentiation. J Pathol 241:405–419. https://doi.org/10.1002/path.4837

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The authors thank all the medical technologists at the Department of Clinical Laboratory, Seirei Hamamatsu General Hospital, Hamamatsu, Japan, for their excellent technical assistance.

Author information

Authors and Affiliations

  1. Department of Pathology, Seirei Hamamatsu General Hospital, 2-12-12 Sumiyoshi, Chuo-Ku, Hamamatsu, 430-8558, Japan

    Yoshiro Otsuki, Yuki Asano & Hiroshi Kobayashi

  2. Department of Clinical Laboratory, Seirei Hamamatsu General Hospital, Hamamatsu, Japan

    Tomonari Ikeya, Yuki Ishida & Shota Sezaki

  3. Department of Pathology, Tachikawa General Hospital, Nagaoka, Japan

    Hiroshi Kobayashi

Authors
  1. Yoshiro Otsuki
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yuki Asano
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Tomonari Ikeya
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yuki Ishida
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Shota Sezaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Hiroshi Kobayashi
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by Yoshiro Otsuki and Hiroshi Kobayashi. Yoshiro Otsuki, Yuki Asano, and Hiroshi Kobayashi were involved in evaluating the immunohistochemistry. The first draft of the manuscript was written by Yoshiro Otsuki and Hiroshi Kobayashi, and all the authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Yoshiro Otsuki.

Ethics declarations

Competing interests

The authors declare no competing interests.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary Information

Below is the link to the electronic supplementary material.

Supplementary file1 (DOCX 28 KB)

Supplementary file2 (DOCX 47 KB)

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Otsuki, Y., Asano, Y., Ikeya, T. et al. A morphological and immunohistochemical study of ductal carcinoma in situ, invasive breast carcinoma of no special type, and mucinous carcinoma of the breast in comparison with solid papillary carcinoma regarding neuroendocrine marker expression. Virchows Arch (2024). https://doi.org/10.1007/s00428-024-03857-x

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s00428-024-03857-x

Keywords

Search

Navigation