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Identification of peripheral anterior synechia with anterior segment optical coherence tomography

  • Glaucoma
  • Published:
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Abstract

Purpose

To generate a model that evaluates the presence and extent of peripheral anterior synechia (PAS) based on anterior segment optical coherence tomography (AS-OCT).

Methods

The extent of PAS involvement in the eyes of patients with angle closure was assessed by indentation gonioscopy, and the part of non-PAS and PAS were assigned into two groups (NPAS and PAS). Anterior chamber angles were then imaged by AS-OCT with light-emitting diode (LED) irradiation directly into the pupils, leading to pupillary constriction and increasing anterior chamber angle width. Parameters including the angle opening distance at 750 μm anterior to the scleral spur (AOD750) and trabecular-iris space area at 750 μm anterior to the scleral spur (TISA750) were then obtained. The differences before and after LED irradiation of AOD750 and TISA750 were calculated and used to generate a PAS model based on binary logistic regression. Validation data were then tested.

Results

A total of 258 AS-OCT images in 14 eyes were assigned to the modeling data, and 120 were assigned to the validation data. There were no differences in AOD750 and TISA750 in the dark between NPAS and PAS (PAOD750 = 0.258, PTISA750 = 0.486), whereas after LED light exposure, TISA750light was larger in NPAS than in PAS (P = 0.047). The light–dark differences of both parameters showed significant differences between the two groups (PAOD750dif = 0.019, PTISA750dif < 0.001). The area under the curve of the model performance was 0.841, and the overall correct rate was 80.8% based on the validation data.

Conclusions

The present study demonstrates that the AS-OCT-based PAS model could be useful in the identifying of the presence of synechial angle closure and evaluating the extent of PAS in a single eye.

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Data availability

Not Applicable.

Code availability

Not applicable.

Abbreviations

AS-OCT:

Anterior segment optical coherence tomography

PAS:

Peripheral anterior synechia

ACA:

Anterior chamber angle

IOP:

Intraocular pressure

SPSS:

The Statistical Package for the Social Sciences

ITC:

Iridotrabecular contact

LED:

Light emitting diode

AOD:

Angle opening distance

TISA:

Trabecular-iris space area

AUC:

Area under the curve

ROC:

Receiver operating characteristic

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Funding

This work was supported by the [Natural Science Foundation of Zhejiang Province] under Grant [No. LY18H180008] and [Optometry Engineering Technology Development Project of Zhejiang Eye Hospital] under Grant [No. GCKF201603].

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Authors and Affiliations

  1. Zhejiang Industry and Trade Vocational College, Wenzhou, Zhejiang, China

    Yingying Dai

  2. School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China

    Shaodan Zhang, Meixiao Shen, Zi **, Yuheng Zhou, Shuling Ye, Chenhong Bao & Dexi Zhu

Authors
  1. Yingying Dai
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  2. Shaodan Zhang
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  3. Meixiao Shen
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  4. Zi **
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  5. Yuheng Zhou
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  6. Shuling Ye
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  7. Chenhong Bao
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  8. Dexi Zhu
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Contributions

Yingying Dai contributed to data collection and analysis, and wrote the manuscript. Shuling Ye and Chenhong Bao contributed to data collection. Zi ** and Yuheng Zhou interpreted the data. Meixiao Shen and Shaodan Zhang were the main contributors to manuscript discussion. Dexi Zhu revised the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Dexi Zhu.

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Ethics approval

This study was conducted in accordance with the Declaration of Helsinki and approved by the ethics committee board of Wenzhou Medical University.

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All subjects, recruited voluntarily, were informed about the purposes, methods, and potential risks of the study. A signed consent form was obtained from each patient.

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The authors declare no competing interests.

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Dai, Y., Zhang, S., Shen, M. et al. Identification of peripheral anterior synechia with anterior segment optical coherence tomography. Graefes Arch Clin Exp Ophthalmol 259, 2753–2759 (2021). https://doi.org/10.1007/s00417-021-05220-1

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  • DOI: https://doi.org/10.1007/s00417-021-05220-1

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