Abstract
A 41-year-old healthy Caucasian male showed an unidentifiable direct AB0 group and a B group by an indirect method revealing the presence of natural antibodies anti-A1 and anti-A2. Mixed fields with anti-B and anti-A+B antisera led to the conclusion that blood group B and 0 cell populations were present in a 1:1 ratio. A negative anamnesis for both transplantation and transfusion suggested a chimerism. DNA analysis of tissues revealed a tetragametic chimerism due to an apparent double parental contribution of nuclei in a phenotypically normal man.
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References
Mosebach M, Parkner A, Jakubiczka S, Wieacker P, Heim MU (2006) Dispermic chimerism identified during blood group determination and HLA ty**. Transfusion 46:1978–1981
Dini G, Floris R, Garaventa A et al (2000) Long-term follow-up of two children with a variant of mild autosomal recessive osteopetrosis undergoing bone marrow transplantation. Bone Marrow Transplant 26:219–224
Bader P, Niethammer D, Willasch A, Kreyenberg H, Klingebiel T (2005) How and when should we monitor chimerism after allogenic stem cell transplantation? Bone Marrow Transplant 35:107–119
Bolan CD, Leitman SF, Griffith LM et al (2001) Delayed donor red cell chimerism and pure red cell aplasia following major AB0-incompatible nonmyeloablative hematopoietic stem cell transplantation. Blood 91:1687–1694
Cho D, Lee SK, Yazer MH et al (2007) A dispermic chimera with mixed field blood group B and mosaic 46, XY/47, XYY karyotype. J Korean Med Sci 22:553–556
Gusmão L, Butler JM, Carracedo A et al (2006) DNA Commission of the International Society of Forensic Genetics (ISFG): an update of the recommendations on the use of Y-STRs in forensic analysis. Int J Legal Med 120:191–200
De Stefano F, Casarino L, Mannucci A, Costa MG, Bruni G (1995) Automated profiling of multiplexed DNA markers. An Italian database of 4 co-amplified STRs loci. Advances in Forensic Haemogenetics 6:174–176
Fracasso T, Schürenkamp M, Brinkmann B, Hohoff C (2008) An X-STR meiosis study in Kurds and Germans: allele frequencies and mutation rates. Int J Legal Med 122:353–356
Boklage CE (2006) Embryogenesis of chimeras, twins and anterior midline asymmetries. Hum Reprod 21:579–591
Drexler C, Glock B, Vadon M et al (2005) Tetragametic chimerism detected in a healthy woman with mixed-field agglutination reactions in AB0 blood grou**. Transfusion 45:698–703
Yu N, Krushall MS, Yunis JJ et al (2002) Disputed maternity leading to identification of tetragametic chimerism. N Engl J Med 346:1545–1552
Castella V, del Mar Lesta M, Mangin P (2009) One person with two DNA profiles: a(nother) case of mosaicism or chimerism. Int J Legal Med In press
Acknowledgement
We thank Prof. Mario Sessarego for the cytogenetic analysis.
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Verdiani, S., Bonsignore, A., Casarino, L. et al. An unusual observation of tetragametic chimerism: forensic aspects. Int J Legal Med 123, 431–435 (2009). https://doi.org/10.1007/s00414-009-0332-0
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DOI: https://doi.org/10.1007/s00414-009-0332-0