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The effects of re-irradiation on the chemical and morphological properties of permanent teeth

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Abstract

This study aimed to assess the in vitro effects of re-irradiation on enamel and dentin properties, simulating head and neck cancer radiotherapy retreatment. Forty-five human permanent molars were classified into five groups: non-irradiated; irradiated 60 Gy, and re-irradiated with doses of 30, 40, and 50 Gy. Raman spectroscopy, scanning electron microscopy (SEM), and energy dispersive x-ray spectroscopy (EDS) were employed for analysis. Raman spectroscopy assessed intensity, spectral area, and specific peaks comparatively. Statistical analysis involved Kolmogorov–Smirnov and One-Way ANOVA tests, with Tukey’s post-test (significance level set at 5%). Significant changes in irradiated, non-irradiated, and re-irradiated enamel peaks were observed, including phosphate (438 nm), hydroxyapatite (582 nm), phosphate (960 nm), and carbonate (1070 nm) (p < 0.05). Re-irradiation affected the entire tooth (p > 0.05), leading to interprismatic region degradation, enamel prism destruction, and hydroxyapatite crystal damage. Dentin exhibited tubule obliteration, crack formation, and progressive collagen fiber fragmentation. EDX revealed increased oxygen percentage and decreased phosphorus and calcium post-reirradiation. It is concluded that chemical and morphological changes in irradiated permanent teeth were dose-dependent, exacerbated by re-irradiation, causing substantial damage in enamel and dentin.

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The authors declare that all data supporting the findings of this study are available within the paper.

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Authors and Affiliations

  1. Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Av. Do Café-Subsetor Oeste-11 (N-11), Ribeirão Preto, São Paulo, 14040-904, Brazil

    Thais Tedeschi dos Santos, Kelly Fernanda Molena, Francisco Wanderley Garcia de Paula-Silva, Juliana Jendiroba Faraoni, Paulo Nelson-Filho & Alexandra Mussolino de Queiroz

  2. São Carlos Institute of Physics, University of São Paulo, São Carlos, Brazil

    Vicente Silva Mattos & Jarbas Caiado de Castro Neto

  3. Centro de Tratamento Em Radio-Oncologia (CTR), Ribeirão Preto Medical School (FMRP), Universidade de São Paulo (USP)-Ribeirão Preto/SP, Hospital Márcio Cunha (HMC), Ipatinga/MG, Brasil

    Harley Francisco de Oliveira

  4. Department of Restorative Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil

    Regina Guenka Palma-Dibb

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  1. Thais Tedeschi dos Santos
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  2. Vicente Silva Mattos
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Contributions

Writing—original draft, Investigation, Methodology: Thais Tedeschi dos Santos; Formal analysis, Writing—review & editing: Vicente Silva Mattos; Writing—review & editing: Kelly Fernanda Molena; Formal analysis: Francisco Wanderley Garcia de Paula-Silva; Resources: Harley Francisco de Oliveira; Formal analysis: Juliana Jendiroba Faraoni and Paulo Nelson-Filho; Supervision, Formal analysis: Jarbas Caiado de Castro Neto; Resources: Regina Guenka Palma-Dibb; Conceptualization; Writing—original draft, Supervision: Alexandra Mussolino de Queiroz.

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Correspondence to Kelly Fernanda Molena.

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The research was approved by the Research Ethics Committee (process no. 2018.3.091.548) for the use of extracted teeth of Biobank Human Teeth School of Dentistry of Ribeirão Preto, University of São Paulo. Consent for permanent tooth donation was given in writing by the patient.

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dos Santos, T.T., Mattos, V.S., Molena, K.F. et al. The effects of re-irradiation on the chemical and morphological properties of permanent teeth. Radiat Environ Biophys 63, 283–295 (2024). https://doi.org/10.1007/s00411-024-01068-1

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