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Investigating the burden of cardiovascular comorbidities in inpatient non-melanoma skin cancer outcomes

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Abstract

While cardiovascular comorbidities can affect the outcomes of a variety of conditions, to our knowledge, few studies have evaluated their impact on non-melanoma skin cancers (NMSC). We studied the National Inpatient Sample to evaluate the impact of cardiovascular comorbidities on NMSC hospitalizations. Our findings displayed higher cost of care (Beta 5053; SE 1150; P < 0.001), length of stay (Beta 1.8; SE 0.394; P < 0.001), and mortality (aOR 2.51; CI 1.49–4.21; P < 0.001) in patients with NMSC who had an associated cardiovascular comorbidity. Specifically, patients with cerebrovascular disease (aOR 3.52; CI 1.18–10.5; P = 0.024), heart failure (aOR 4.02; CI 2.29–7.05; P < 0.001), complicated hypertension (OR 2.05; CI 1.16–3.61; P = 0.013), and pulmonary circulation disease (aOR 3.33; CI 1.13–9.78; P = 0.029) demonstrated greater odds of mortality.

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Data availability

The data that support the findings of this study are openly available through the Healthcare Cost and Utilization Project by the Agency for Healthcare Research and Quality at https://www.hcup-us.ahrq.gov/db/nation/nis/nisdbdocumentation.jsp.

References

  1. Rogers HW, Weinstock MA, Feldman SR, Coldiron BM (2015) Incidence estimate of nonmelanoma skin cancer (Keratinocyte Carcinomas) in the U.S. population, 2012. JAMA Dermatol 151:1081–1086

    Article  PubMed  Google Scholar 

  2. (2016–2019) HCUP National Inpatient Sample (NIS). Healthcare Cost and Utilization Project (HCUP)

  3. R Core Team (2022) R: a language and environment for statistical computing

  4. John Chen G, Yelverton CB, Polisetty SS et al (2006) Treatment patterns and cost of nonmelanoma skin cancer management. Dermatol Surg 32:1266–1271

    CAS  PubMed  Google Scholar 

  5. Senet P, Combemale P, Debure C et al (2012) Malignancy and chronic leg ulcers: the value of systematic wound biopsies: a prospective, multicenter, cross-sectional study. Arch Dermatol 148:704–708

    Article  PubMed  Google Scholar 

  6. Wang A, Stefanick ML, Kapphahn K et al (2016) Relation of statin use with non-melanoma skin cancer: prospective results from the Women’s Health Initiative. Br J Cancer 114:314–320

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Pedersen SA, Gaist D, Schmidt SAJ et al (2018) Hydrochlorothiazide use and risk of nonmelanoma skin cancer: a nationwide case-control study from Denmark. J Am Acad Dermatol 78:673-681.e9

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA

    Shrey Patel, Daphne G. Eckembrecher, Francelia J. Eckembrecher, Jamie K. Hu, Eran Gwillim & Keyvan Nouri

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  1. Shrey Patel
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  2. Daphne G. Eckembrecher
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  3. Francelia J. Eckembrecher
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  4. Jamie K. Hu
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  5. Eran Gwillim
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  6. Keyvan Nouri
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Contributions

S.P. prepared tables. All authors have assisted in preparation and reviewing the manuscript.

Corresponding author

Correspondence to Shrey Patel.

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All authors declare no conflicts of interest.

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IRB approval was not required as the study uses a publicly available data source with de-identified information.

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Patel, S., Eckembrecher, D.G., Eckembrecher, F.J. et al. Investigating the burden of cardiovascular comorbidities in inpatient non-melanoma skin cancer outcomes. Arch Dermatol Res 315, 2167–2169 (2023). https://doi.org/10.1007/s00403-023-02591-9

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  • DOI: https://doi.org/10.1007/s00403-023-02591-9

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