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Molecularly imprinted polymers based on attapulgite and sustained-release properties for 5-FU

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Abstract

In this study, a novel molecularly imprinted polymer (MIP) was synthesized with attapulgite (ATP) and acrylamide (AM) and ethyl methacrylate (MMA) for controlled release carrier of 5-fluorouracil (5-FU). The MIPs (PAM-PMMA) were characterized by XRD, FESEM, HRTEM, and FTIR. The drug loading and in vitro controlled release ability of MIP on 5-FU was investigated by adsorption property analysis and in vitro release analysis. MIPs (PAM-PMMA) reached a maximum drug loading of 12 mg/g and a maximum release of 80% at an ATP dosage of 0.2 g (0.4%), an initial concentration of 5-FU of 100 mg/L, and an adsorption time of 240 min. Cytotoxicity analysis showed that the maximum inhibition of cells could reach 25% at 72 h of cell culture time under the above conditions. The results showed that MIPs synthesized with ATP as the substrate and AM and MMA as the functional monomers were successfully synthesized and could be used as a drug delivery system for 5-FU.

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Funding

The project is supported by the Hubei Provincial Science and Technology Innovation Team Program for Excellent Middle-aged in Higher Education Institutions (NO.T2022019) and the Hubei Minzu University Graduate Student Innovation Program (MYK2023002).

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Authors and Affiliations

  1. School of Chemical and Environmental Engineering, Hubei Minzu University, Enshi, China

    **nyuan Ji, Zhe Yang, Jiahui Fang & Sheng Hu

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  1. **nyuan Ji
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  2. Zhe Yang
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  3. Jiahui Fang
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Contributions

X.J. wrote the main manuscript text, Z.Y. did the preparations, J.F. prepared figures and tables, and S.H. reviewed the manuscript. All authors reviewed the manuscript.

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Correspondence to Sheng Hu.

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Ji, X., Yang, Z., Fang, J. et al. Molecularly imprinted polymers based on attapulgite and sustained-release properties for 5-FU. Colloid Polym Sci 302, 819–828 (2024). https://doi.org/10.1007/s00396-024-05237-y

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