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Risk factors for catheter-related bloodstream infections in patients with intestinal failure undergoing home parenteral nutrition: a single-center study

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Abstract

Purpose

The incidence and risk factors of catheter-related bloodstream infections (CRBSI) in patients with intestinal failure (IF) have not been established, partly because catheter management methods vary from different facilities. This study aimed to identify the risk factors and incidence rate of CRBSIs in patients with IF who were given prophylactic treatment.

Methods

Sixteen patients with IF who required home parenteral nutrition were enrolled in this study. Prophylactic management of CRBSI included monthly ethanol lock therapy and standardized infection prevention education. The outcomes included the incidence and risk factors of CRBSI.

Results

The median incidence rate of CRBSI was 1.2 per 1000 catheter days. Univariate analysis showed that the risk of develo** CRBSI was significantly associated with short bowel syndrome (< 30 cm) (p = 0.016). Other relevant findings included a significant negative correlation between serum albumin and CRBSI rate (r = − 0.505, p = 0.046), and past history of mixed bacterial infections was significantly associated with increased CRBSI rate (p = 0.013).

Conclusion

CRBSIs can still develop despite undergoing prophylactic management. Risk factors for CRBSI include the residual intestinal length, nutritional status, and susceptibility to certain microorganisms.

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Data availability

The data supporting the findings of this study are available from the corresponding author upon reasonable request.

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Acknowledgements

We would like to thank Editage (www.editage.com) for the English language editing.

Funding

No funding was received for conducting this study.

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Authors and Affiliations

  1. Department of Pediatric Surgery, Tohoku University Hospital, Sendai, 980-8574, Japan

    Tsuyoshi Sakurai, Megumi Nakamura, Hideyuki Sasaki, Taichi Fukuzawa, Hironori Kudo, Ryo Ando, Ryuji Okubo, Masatoshi Hashimoto, Kesuke Tada & Motoshi Wada

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  1. Tsuyoshi Sakurai
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Contributions

TS designed the study and performed the analyses, and wrote the main manuscript text. MN, HS, TF, HK, RA, RO, MH, and KT reviewed the manuscript and provided critical feedback. MW supervised all of the study. All authors reviewed the manuscript.

Corresponding author

Correspondence to Motoshi Wada.

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Conflict of interest

The authors declare that they have no conflicts of interest.

Ethical approval

This study was approved by the ethics committee of Tohoku University Hospital (Approval No. 29924) and has been performed in accordance with the ethical standards laid down in the Declaration of Helsinki, 1964 and its later amendments.

Informed consent

The institutional review board approved this retrospective study, and the requirement for informed consent was waived.

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Sakurai, T., Nakamura, M., Sasaki, H. et al. Risk factors for catheter-related bloodstream infections in patients with intestinal failure undergoing home parenteral nutrition: a single-center study. Pediatr Surg Int 39, 283 (2023). https://doi.org/10.1007/s00383-023-05555-2

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